（概要）
2026（令和8年）年度「科学的リテラシーのトレーニング：上級編（第7期）」として、Journal Clubを行なっています。徹底的理解と批判的読解力、プレゼン力、質疑応答力、自らの研究への応用力を鍛えています。Pre-JCでは、課題論文のコアデータを紹介し概要を把握して議論し、最新の知見を総覧します（浅読みのトレーニング）。JCでは、Pre-JCから選択した論文を、徹底的に読み込み、議論します（深読みのトレーニング）。また、東京大学大学院医学系研究科・疋田温彦先生研究室との合同JCで、研究室間交流を行います。
2026年度は19報の論文について議論しました。

2026ｰ0721
東京大学・疋田研との合同JC
小野紗也加　先生（東京大学・助教）
Choi, A. et al.
Spatially resolved osteoblast-traced transcriptomics uncovers TGF-beta as a combination target with sclerostin in osteoporosis.
Bone Res 14 (2026).
https://doi.org:10.1038/s41413-026-00521-9

孝口里侑（口腔診断内科学・大学院4年生）
Jiang, B. et al.
Fibrous-layer resident Angptl7(+) periosteal stem cells sense injury inflammation to orchestrate fracture repair.
Cell Res 36, 121-136 (2026).
https://doi.org:10.1038/s41422-025-01202-8


2026-0714
PreｰJC
包 　朗
Ambrosi, T. H. et al.
Basigin links altered skeletal stem cell lineage dynamics with glucocorticoid-induced bone loss and impaired angiogenesis.
Nat Commun 16, 7606 (2025).
https://doi.org:10.1038/s41467-025-62881-w
Zhai, Y., Zhou, Z., Xing, X., Nuzzle, M. & Zhang, X.
Differential bone and vessel type formation at superior and dura periosteum during cranial bone defect repair.
Bone Res 13, 8 (2025).
https://doi.org:10.1038/s41413-024-00379-9
Costa, S. N. et al.
Expansion of bone marrow adipocytes in obese mice leads to PD-L1-driven bone marrow immunosuppression and osteoclastogenesis.
Bone Res 14 (2026).
https://doi.org:10.1038/s41413-026-00509-5


2026ｰ0707

PreｰJC
孝口里侑
Jiang, B. et al.
Fibrous-layer resident Angptl7(+) periosteal stem cells sense injury inflammation to orchestrate fracture repair.
Cell Res 36, 121-136 (2026).
https://doi.org:10.1038/s41422-025-01202-8
Turkkahraman, H. et al.
Loss of PTH 1 receptor signaling in periodontal cells drives cementum dysfunction and molar ankylosis in mice.
Bone Res 14 (2026).
https://doi.org:10.1038/s41413-026-00533-5
Zhu, Z. et al.
Luminal surface proteome of the brain vasculature uncovers blood-brain barrier regulators.
Science 392, eaea2100 (2026).
https://doi.org:10.1126/science.aea2100


2026-0630
JC

竹本竜太郎
Qi, X. et al.
Neutrophil-initiated nociceptive ingrowth orchestrates inflammation resolution to potentiate bone regeneration.
Bone Res 14, 9 (2026).
https://doi.org:10.1038/s41413-025-00481-6


2026-0623
JC

堀井奈々子
Lehmann, J. et al.
The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation.
Signal Transduct Target Ther 10, 199 (2025).
https://doi.org:10.1038/s41392-025-02291-y


2026ｰ0616
PreｰJC

堀井奈々子
Lehmann, J. et al.
The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation.
Signal Transduct Target Ther 10, 199 (2025).
https://doi.org:10.1038/s41392-025-02291-y
Zhang, P. et al.
Bone homeostasis regulation by in vivo generation of osteoclast-derived apoptotic bodies using targeted self-assembly.
Nat Commun 17, 88 (2025).
https://doi.org:10.1038/s41467-025-66791-9
Li, J. et al.
A RANKL(+)/CXCR4(+) B cell population accumulates in bone marrow and causes age-related osteoporosis in mice.
Bone Res 14 (2026).
https://doi.org:10.1038/s41413-026-00525-5


2026ｰ0609
JC

辻直紀
Inagaki, S. et al.
Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo.
Nat Methods 23, 839-853 (2026).
https://doi.org:10.1038/s41592-026-03023-y


2026ｰ0602
PreｰJC
竹本竜太郎
Dou, C. et al.
Estradiol regulates osteoclast sialylation via ST3Gal1 in postmenopausal osteoporosis.
Bone Res 14, 22 (2026).
https://doi.org:10.1038/s41413-025-00498-x
Schulte, F. A. et al.
Combined physical and pharmacological anabolic osteoporosis therapies increase bone response and mechanoregulation in female mice.
Nat Commun 17 (2026).
https://doi.org:10.1038/s41467-026-70309-2
Qi, X. et al.
Neutrophil-initiated nociceptive ingrowth orchestrates inflammation resolution to potentiate bone regeneration.
Bone Res 14, 9 (2026).
https://doi.org:10.1038/s41413-025-00481-6


2026ｰ0526
JC

倉兼悠輔
Liu, X., Ye, Y., Li, Z., Liao, L. & Wei, Q.
Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling.
Nat Commun 17, 1684 (2026).
https://doi.org:10.1038/s41467-026-68387-3


2026ｰ0519
PreｰJC

辻直紀
Eme-Scolan, E. et al.
Remodeling of skull bone channels regulates immune infiltration into the meninges during neuroinflammation.
Immunity 59, 116-128 e117 (2026).
https://doi.org:10.1016/j.immuni.2025.11.019
Chu, N. T. L. et al.
Three-dimensional quantitative tissue clearing reveals differences in osteovascular niche of aged and young human mesenchymal stromal cells.
Nat Biomed Eng (2026).
https://doi.org:10.1038/s41551-026-01645-3
Inagaki, S. et al.
Isotonic and minimally invasive optical clearing media for live cell imaging ex vivo and in vivo.
Nat Methods 23, 839-853 (2026).
https://doi.org:10.1038/s41592-026-03023-y


0512
JC

包 朗
Chen, Z. et al.
Autocrine ECM molecules establish MSC quiescence during incisor development by disrupting WNT ligand trafficking process.
Nat Commun 16, 10676 (2025).
https://doi.org:10.1038/s41467-025-65705-z


2026ｰ0421
PreｰJC

倉兼悠輔
Costa, S. N. et al.
Expansion of bone marrow adipocytes in obese mice leads to PD-L1-driven bone marrow immunosuppression and osteoclastogenesis.
one Res 14 (2026).
https://doi.org:10.1038/s41413-026-00509-5
Liu, J. et al.
Sensory Nerve-Derived CGRP Controls Osteoclastogenesis by Limiting Macrophage Bioenergetics in Bone Repair.
Adv Sci (Weinh) 13, e18303 (2026).
https://doi.org:10.1002/advs.202518303
Liu, X., Ye, Y., Li, Z., Liao, L. & Wei, Q.
Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling.
Nat Commun 17, 1684 (2026).
https://doi.org:10.1038/s41467-026-68387-3