2025（令和7年）年度「科学的リテラシーのトレーニング：上級編（第7期）」として、Journal Clubを行なっています。徹底的理解と批判的読解力、プレゼン力、質疑応答力、自らの研究への応用力を鍛えています。Pre-JCでは、課題論文のコアデータを紹介し概要を把握して議論し、最新の知見を総覧します（浅読みのトレーニング）。JCでは、Pre-JCから選択した論文を、徹底的に読み込み、議論します（深読みのトレーニング）。また、東京大学大学院医学系研究科・疋田温彦先生研究室との合同JCで、研究室間交流を行います。
2025年度は16報の論文について議論しました。

202500617
Pre Journal Club
発表者：竹本　竜太朗
Dvorakova, M. et al.
Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for nociception.
Cell Rep Med, 102139 (2025).
https://doi.org:10.1016/j.xcrm.2025.102139
Yilmaz, D. et al.
Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging.
Bone Res 13, 55 (2025).
https://doi.org:10.1038/s41413-025-00428-x
Ishikawa, K. et al.
Mouse model of anti-RANKL discontinuation reveals reduced bone mass and quality through disruption of bone remodeling.
Bone Res 13, 56 (2025).
https://doi.org:10.1038/s41413-025-00433-0

202500610
東京大学大学院医学系研究科・疋田温彦先生研究室との合同JC

発表者：辻 直紀　先生　（東京大学）
Liao, P. et al.
Osteocyte mitochondria regulate angiogenesis of transcortical vessels.
Nat Commun 15, 2529 (2024).
https://doi.org:10.1038/s41467-024-46095-0
発表者：渡辺　陽久　（北海道大学　薬理学教室）
Ambrosi, T. H. et al.
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites.
Cell Stem Cell 32, 811-823 e811 (2025).
https://doi.org:10.1016/j.stem.2025.02.013

20250603 Pre Journal Club
発表者：孝口　里侑
Yuan, H. et al.
NELL2, a novel osteoinductive factor, regulates osteoblast differentiation and bone homeostasis through fibronectin 1/integrin-mediated FAK/AKT signaling.
Bone Res 13, 46 (2025).
https://doi.org:10.1038/s41413-025-00420-5
Zondervan, R. L. et al.
CD47 is required for mesenchymal progenitor proliferation and fracture repair.
Bone Res 13, 29 (2025).
https://doi.org:10.1038/s41413-025-00409-0
Fan, S. et al.
WAC Facilitates Mitophagy-mediated MSC Osteogenesis and New Bone Formation via Protecting PINK1 from Ubiquitination-Dependent Degradation.
Adv Sci (Weinh) 12, e2404107 (2025).
https://doi.org:10.1002/advs.202404107

20250527 Journal Club
発表者：上野　楓実
Koh, B. I. et al.
Adult skull bone marrow is an expanding and resilient haematopoietic reservoir.
Nature 636, 172-181 (2024).
https://doi.org:10.1038/s41586-024-08163-9

20250520 Pre Journal Club
発表者：上野　楓実
Yao, Z. et al.
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects.
Bone Res 12, 52 (2024).
https://doi.org:10.1038/s41413-024-00352-6
Koh, B. I. et al.
Adult skull bone marrow is an expanding and resilient haematopoietic reservoir.
Nature 636, 172-181 (2024).
https://doi.org:10.1038/s41586-024-08163-9
Chen, L. et al.
Attenuation of Alzheimer's brain pathology in 5XFAD mice by PTH(1-34), a peptide of parathyroid hormone.
Alzheimers Res Ther 15, 53 (2023).
https://doi.org:10.1186/s13195-023-01202-z

20250513 Journal Club
発表者：高田健太郎 （理学院自然史科学専攻　小林快次教授研究室）
Walter, J. D. et al.
Expanded phylogeny elucidates Deinosuchus relationships, crocodylian osmoregulation and body-size evolution.
Commun Biol 8, 611 (2025).
https://doi.org:10.1038/s42003-025-07653-4

20250422 Journal Club
発表者：飯村　忠浩
Zhang, L. et al.
Bidirectional control of parathyroid hormone and bone mass by subfornical organ.
Neuron 111, 1914-1932 e1916 (2023).
https://doi.org:10.1016/j.neuron.2023.03.030

20250415 Pre Journal Club
発表者：渡辺　陽久
Zhao, L., Liu, S., Peng, Y. & Zhang, J.
Lamc1 promotes osteogenic differentiation and inhibits adipogenic differentiation of bone marrow-derived mesenchymal stem cells.
Sci Rep 14, 19592 (2024).
https://doi.org:10.1038/s41598-024-69629-4
Hou, J. et al.
Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence.
Nat Aging 4, 1562-1581 (2024).
https://doi.org:10.1038/s43587-024-00694-0
Ambrosi, T. H. et al.
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites.
Cell Stem Cell 32, 811-823 e811 (2025).
https://doi.org:10.1016/j.stem.2025.02.013

20250408 Journal Club
発表者：西本　慎之介
Nakano-Kobayashi, A., Canela, A., Yoshihara, T. & Hagiwara, M.
Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway.
Proc Natl Acad Sci U S A 120, e2303809120 (2023).
https://doi.org:10.1073/pnas.2303809120