2025（令和7年）年度「科学的リテラシーのトレーニング：上級編（第7期）」として、Journal Clubを行なっています。徹底的理解と批判的読解力、プレゼン力、質疑応答力、自らの研究への応用力を鍛えています。Pre-JCでは、課題論文のコアデータを紹介し概要を把握して議論し、最新の知見を総覧します（浅読みのトレーニング）。JCでは、Pre-JCから選択した論文を、徹底的に読み込み、議論します（深読みのトレーニング）。また、東京大学大学院医学系研究科・疋田温彦先生研究室との合同JCで、研究室間交流を行います。
2025年度は38報の論文について議論しました。

2025_1118
Journal Club
発表者：上野楓実
The p75 neurotrophin receptor controls the skeletal stem cell niche through sensory innervation.
Dev Cell (2025).
https://doi.org:10.1016/j.devcel.2025.09.012

2025_1111
Pre Journal Club
発表者：竹本竜太朗
Zhang, X. et al.
Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment.
Nat Commun 16, 6200 (2025).
https://doi.org:10.1038/s41467-025-61619-y
Nayer, B. et al.
Local administration of regulatory T cells promotes tissue healing.
Nat Commun 15, 7863 (2024).
https://doi.org:10.1038/s41467-024-51353-2
Ninkovic, N. et al.
Mesenchymal progenitor-derived proteoglycan 4 regulates the transdifferentiation of chondrocytes into osteoblasts during fracture healing.
Stem Cells Transl Med 14 (2025).
https://doi.org:10.1093/stcltm/szaf043

2025_1107
Journal Club
発表者：渡辺陽久
Motoike, S., Inada, Y., Toguchida, J., Kajiya, M. & Ikeya, M.
Jawbone-like organoids generated from human pluripotent stem cells.
Nat Biomed Eng (2025).
https://doi.org:10.1038/s41551-025-01419-3

2025_1021
Pre Journal Club
発表者：上野楓実
Lu, S. et al.
Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice.
Nat Commun 16, 8127 (2025).
https://doi.org:10.1038/s41467-025-63456-5
Wu, Z. et al.
The p75 neurotrophin receptor controls the skeletal stem cell niche through sensory innervation.
Dev Cell (2025).
https://doi.org:10.1016/j.devcel.2025.09.012
Wu, D. et al. Estrogen loss activates memory T-cells to compromise bone integrity through distinct cortical compartments in mice.
J Bone Miner Res 40, 1087-1099 (2025).
https://doi.org:10.1093/jbmr/zjaf089

2025_0914
Journal Club
発表者：西本慎之介
Zhang, F. et al.
Secretin-dependent signals in the ventromedial hypothalamus regulate energy metabolism and bone homeostasis in mice.
Nat Commun 15, 1030 (2024).
https://doi.org:10.1038/s41467-024-45436-3

2025_1007
Pre Journal Club
発表者：渡辺陽久
Wang, T. et al.
Pulsed electromagnetic fields mediate sensory nerve regulation for bone formation in aging models.
Nat Commun 16, 8223 (2025).
https://doi.org:10.1038/s41467-025-63703-9
Motoike, S., Inada, Y., Toguchida, J., Kajiya, M. & Ikeya, M.
Jawbone-like organoids generated from human pluripotent stem cells.
Nat Biomed Eng (2025).
https://doi.org:10.1038/s41551-025-01419-3
Wang, Z. et al.
Identification of human cranio-maxillofacial skeletal stem cells for mandibular development.
Sci Adv 11, eado7852 (2025).
https://doi.org:10.1126/sciadv.ado7852

2025_0916
Journal Club
発表者：倉兼悠輔
Jiang, Y. et al.
Membrane-initiated estrogen receptor-alpha signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice.
Bone Res 13, 65 (2025).

2025_0909
Pre Journal Club
発表者：西本慎之介
Peruzzotti-Jametti, L. et al.
Mitochondrial complex I activity in microglia sustains neuroinflammation.
Nature 628, 195-203 (2024).
https://doi.org:10.1038/s41586-024-07167-9
Zhang, F. et al.
Secretin-dependent signals in the ventromedial hypothalamus regulate energy metabolism and bone homeostasis in mice.
Nat Commun 15, 1030 (2024).
https://doi.org:10.1038/s41467-024-45436-3
Yu, C. et al.
Exercise ameliorates osteopenia in mice via intestinal microbial-mediated bile acid metabolism pathway.
Theranostics 15, 1741-1759 (2025).
https://doi.org:10.7150/thno.104186

2025_0902
Journal Club
発表者：包　朗　（Bao Lang）
Liu, Y. L., Tang, X. T., Shu, H. S., Zou, W. & Zhou, B. O.
Fibrous periosteum repairs bone fracture and maintains the healed bone throughout mouse adulthood.
Dev Cell 59, 1192-1209 e1196 (2024).

2025_715
Pre Journal Club
発表者：倉兼悠輔
Hoppner, J. et al.
Prolonging parathyroid hormone analog action in vitro and in vivo through peptide lipidation. Nat Commun 16, 4487 (2025).
https://doi.org:10.1038/s41467-025-59665-7
Jiang, Y. et al.
Membrane-initiated estrogen receptor-alpha signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice.
Bone Res 13, 65 (2025).
https://doi.org:10.1038/s41413-025-00439-8
Ramteke, P. et al.
Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice.
Bone Res 13, 50 (2025).
https://doi.org:10.1038/s41413-025-00422-3

2025_708
Journal Club
発表者：竹本竜太朗
Ishikawa, K. et al.
Mouse model of anti-RANKL discontinuation reveals reduced bone mass and quality through disruption of bone remodeling.
Bone Res 13, 56 (2025).
https://doi.org:10.1038/s41413-025-00433-0

2025_701
Pre Journal Club
発表者：包　朗　（Bao Lang）
Kodama, J. et al.
Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zone.
Bone Res 13, 31 (2025).
https://doi.org:10.1038/s41413-025-00407-2
Liu, Y. L., Tang, X. T., Shu, H. S., Zou, W. & Zhou, B. O.
Fibrous periosteum repairs bone fracture and maintains the healed bone throughout mouse adulthood.
Dev Cell 59, 1192-1209 e1196 (2024).
https://doi.org:10.1016/j.devcel.2024.03.019
Du, J. et al.
ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis.
Nat Commun 15, 5994 (2024).
https://doi.org:10.1038/s41467-024-50225-z

2025_0701
Pre Journal Club
発表者：飯村忠浩
Lorenz, M. R., Brazill, J. M., Beeve, A. T., Shen, I. & Scheller, E. L.
A Neuroskeletal Atlas: Spatial Mapping and Contextualization of Axon Subtypes Innervating the Long Bones of C3H and B6 Mice.
J Bone Miner Res 36, 1012-1025 (2021).
https://doi.org:10.1002/jbmr.4273
Beeve, A. T. et al.
Spatial histomorphometry reveals that local peripheral nerves modulate but are not required for skeletal adaptation to applied load in mice.
JBMR Plus 9, ziaf006 (2025).
https://doi.org:10.1093/jbmrpl/ziaf006
Biswas, L. et al.
Lymphatic vessels in bone support regeneration after injury.
Cell 186, 382-397 e324 (2023).
https://doi.org:10.1016/j.cell.2022.12.031
Bian, F. et al.
The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH signaling.
J Bone Miner Res 39, 1644-1658 (2024).
https://doi.org:10.1093/jbmr/zjae144

2025_0624 Journal Club
発表者：孝口　里侑
Yuan, H. et al.
NELL2, a novel osteoinductive factor, regulates osteoblast differentiation and bone homeostasis through fibronectin 1/integrin-mediated FAK/AKT signaling.
Bone Res 13, 46 (2025).
https://doi.org:10.1038/s41413-025-00420-5

2025_0617
Pre Journal Club
発表者：竹本　竜太朗
Dvorakova, M. et al.
Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for nociception.
Cell Rep Med, 102139 (2025).
https://doi.org:10.1016/j.xcrm.2025.102139
Yilmaz, D. et al.
Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging.
Bone Res 13, 55 (2025).
https://doi.org:10.1038/s41413-025-00428-x
Ishikawa, K. et al.
Mouse model of anti-RANKL discontinuation reveals reduced bone mass and quality through disruption of bone remodeling.
Bone Res 13, 56 (2025).
https://doi.org:10.1038/s41413-025-00433-0

2025_0610
東京大学大学院医学系研究科・疋田温彦先生研究室との合同JC
発表者：辻 直紀　先生　（東京大学）
Liao, P. et al.
Osteocyte mitochondria regulate angiogenesis of transcortical vessels.
Nat Commun 15, 2529 (2024).
https://doi.org:10.1038/s41467-024-46095-0
発表者：渡辺　陽久　（北海道大学　薬理学教室）
Ambrosi, T. H. et al.
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites.
Cell Stem Cell 32, 811-823 e811 (2025).
https://doi.org:10.1016/j.stem.2025.02.013

2025_0603 Pre Journal Club
発表者：孝口　里侑
Yuan, H. et al.
NELL2, a novel osteoinductive factor, regulates osteoblast differentiation and bone homeostasis through fibronectin 1/integrin-mediated FAK/AKT signaling.
Bone Res 13, 46 (2025).
https://doi.org:10.1038/s41413-025-00420-5
Zondervan, R. L. et al.
CD47 is required for mesenchymal progenitor proliferation and fracture repair.
Bone Res 13, 29 (2025).
https://doi.org:10.1038/s41413-025-00409-0
Fan, S. et al.
WAC Facilitates Mitophagy-mediated MSC Osteogenesis and New Bone Formation via Protecting PINK1 from Ubiquitination-Dependent Degradation.
Adv Sci (Weinh) 12, e2404107 (2025).
https://doi.org:10.1002/advs.202404107

2025_0527 Journal Club
発表者：上野　楓実
Koh, B. I. et al.
Adult skull bone marrow is an expanding and resilient haematopoietic reservoir.
Nature 636, 172-181 (2024).
https://doi.org:10.1038/s41586-024-08163-9

2025_0520 Pre Journal Club
発表者：上野　楓実
Yao, Z. et al.
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects.
Bone Res 12, 52 (2024).
https://doi.org:10.1038/s41413-024-00352-6
Koh, B. I. et al.
Adult skull bone marrow is an expanding and resilient haematopoietic reservoir.
Nature 636, 172-181 (2024).
https://doi.org:10.1038/s41586-024-08163-9
Chen, L. et al.
Attenuation of Alzheimer's brain pathology in 5XFAD mice by PTH(1-34), a peptide of parathyroid hormone.
Alzheimers Res Ther 15, 53 (2023).
https://doi.org:10.1186/s13195-023-01202-z

2025_0513 Journal Club
発表者：高田健太郎 （理学院自然史科学専攻　小林快次教授研究室）
Walter, J. D. et al.
Expanded phylogeny elucidates Deinosuchus relationships, crocodylian osmoregulation and body-size evolution.
Commun Biol 8, 611 (2025).
https://doi.org:10.1038/s42003-025-07653-4

2025_0422 Journal Club
発表者：飯村　忠浩
Zhang, L. et al.
Bidirectional control of parathyroid hormone and bone mass by subfornical organ.
Neuron 111, 1914-1932 e1916 (2023).
https://doi.org:10.1016/j.neuron.2023.03.030

2025_0415 Pre Journal Club
発表者：渡辺　陽久
Zhao, L., Liu, S., Peng, Y. & Zhang, J.
Lamc1 promotes osteogenic differentiation and inhibits adipogenic differentiation of bone marrow-derived mesenchymal stem cells.
Sci Rep 14, 19592 (2024).
https://doi.org:10.1038/s41598-024-69629-4
Hou, J. et al.
Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence.
Nat Aging 4, 1562-1581 (2024).
https://doi.org:10.1038/s43587-024-00694-0
Ambrosi, T. H. et al.
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites.
Cell Stem Cell 32, 811-823 e811 (2025).
https://doi.org:10.1016/j.stem.2025.02.013

2025_0408 Journal Club
発表者：西本　慎之介
Nakano-Kobayashi, A., Canela, A., Yoshihara, T. & Hagiwara, M.
Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway.
Proc Natl Acad Sci U S A 120, e2303809120 (2023).
https://doi.org:10.1073/pnas.2303809120