2025（令和7年）年度「科学的リテラシーのトレーニング：上級編（第7期）」として、Journal Clubを行なっています。徹底的理解と批判的読解力、プレゼン力、質疑応答力、自らの研究への応用力を鍛えています。Pre-JCでは、課題論文のコアデータを紹介し概要を把握して議論し、最新の知見を総覧します（浅読みのトレーニング）。JCでは、Pre-JCから選択した論文を、徹底的に読み込み、議論します（深読みのトレーニング）。また、東京大学大学院医学系研究科・疋田温彦先生研究室との合同JCで、研究室間交流を行います。
2025年度は27報の論文について議論しました。

202500715
Pre Journal Club
発表者：倉兼悠輔
Hoppner, J. et al.
Prolonging parathyroid hormone analog action in vitro and in vivo through peptide lipidation. Nat Commun 16, 4487 (2025).
https://doi.org:10.1038/s41467-025-59665-7
Jiang, Y. et al.
Membrane-initiated estrogen receptor-alpha signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice.
Bone Res 13, 65 (2025).
https://doi.org:10.1038/s41413-025-00439-8
Ramteke, P. et al.
Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice.
Bone Res 13, 50 (2025).
https://doi.org:10.1038/s41413-025-00422-3

202500708
Journal Club
発表者：竹本竜太朗
Ishikawa, K. et al.
Mouse model of anti-RANKL discontinuation reveals reduced bone mass and quality through disruption of bone remodeling.
Bone Res 13, 56 (2025).
https://doi.org:10.1038/s41413-025-00433-0

202500701
Pre Journal Club
発表者：包　朗　（Bao Lang）
Kodama, J. et al.
Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zone.
Bone Res 13, 31 (2025).
https://doi.org:10.1038/s41413-025-00407-2
Liu, Y. L., Tang, X. T., Shu, H. S., Zou, W. & Zhou, B. O.
Fibrous periosteum repairs bone fracture and maintains the healed bone throughout mouse adulthood.
Dev Cell 59, 1192-1209 e1196 (2024).
https://doi.org:10.1016/j.devcel.2024.03.019
Du, J. et al.
ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis.
Nat Commun 15, 5994 (2024).
https://doi.org:10.1038/s41467-024-50225-z

202500701
Pre Journal Club
発表者：飯村忠浩
Lorenz, M. R., Brazill, J. M., Beeve, A. T., Shen, I. & Scheller, E. L.
A Neuroskeletal Atlas: Spatial Mapping and Contextualization of Axon Subtypes Innervating the Long Bones of C3H and B6 Mice.
J Bone Miner Res 36, 1012-1025 (2021).
https://doi.org:10.1002/jbmr.4273
Beeve, A. T. et al.
Spatial histomorphometry reveals that local peripheral nerves modulate but are not required for skeletal adaptation to applied load in mice.
JBMR Plus 9, ziaf006 (2025).
https://doi.org:10.1093/jbmrpl/ziaf006
Biswas, L. et al.
Lymphatic vessels in bone support regeneration after injury.
Cell 186, 382-397 e324 (2023).
https://doi.org:10.1016/j.cell.2022.12.031
Bian, F. et al.
The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH signaling.
J Bone Miner Res 39, 1644-1658 (2024).
https://doi.org:10.1093/jbmr/zjae144

20250624 Journal Club
発表者：孝口　里侑
Yuan, H. et al.
NELL2, a novel osteoinductive factor, regulates osteoblast differentiation and bone homeostasis through fibronectin 1/integrin-mediated FAK/AKT signaling.
Bone Res 13, 46 (2025).
https://doi.org:10.1038/s41413-025-00420-5

202500617
Pre Journal Club
発表者：竹本　竜太朗
Dvorakova, M. et al.
Acetaminophen inhibits diacylglycerol lipase synthesis of 2-arachidonoyl glycerol: Implications for nociception.
Cell Rep Med, 102139 (2025).
https://doi.org:10.1016/j.xcrm.2025.102139
Yilmaz, D. et al.
Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging.
Bone Res 13, 55 (2025).
https://doi.org:10.1038/s41413-025-00428-x
Ishikawa, K. et al.
Mouse model of anti-RANKL discontinuation reveals reduced bone mass and quality through disruption of bone remodeling.
Bone Res 13, 56 (2025).
https://doi.org:10.1038/s41413-025-00433-0

202500610
東京大学大学院医学系研究科・疋田温彦先生研究室との合同JC
発表者：辻 直紀　先生　（東京大学）
Liao, P. et al.
Osteocyte mitochondria regulate angiogenesis of transcortical vessels.
Nat Commun 15, 2529 (2024).
https://doi.org:10.1038/s41467-024-46095-0
発表者：渡辺　陽久　（北海道大学　薬理学教室）
Ambrosi, T. H. et al.
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites.
Cell Stem Cell 32, 811-823 e811 (2025).
https://doi.org:10.1016/j.stem.2025.02.013

20250603 Pre Journal Club
発表者：孝口　里侑
Yuan, H. et al.
NELL2, a novel osteoinductive factor, regulates osteoblast differentiation and bone homeostasis through fibronectin 1/integrin-mediated FAK/AKT signaling.
Bone Res 13, 46 (2025).
https://doi.org:10.1038/s41413-025-00420-5
Zondervan, R. L. et al.
CD47 is required for mesenchymal progenitor proliferation and fracture repair.
Bone Res 13, 29 (2025).
https://doi.org:10.1038/s41413-025-00409-0
Fan, S. et al.
WAC Facilitates Mitophagy-mediated MSC Osteogenesis and New Bone Formation via Protecting PINK1 from Ubiquitination-Dependent Degradation.
Adv Sci (Weinh) 12, e2404107 (2025).
https://doi.org:10.1002/advs.202404107

20250527 Journal Club
発表者：上野　楓実
Koh, B. I. et al.
Adult skull bone marrow is an expanding and resilient haematopoietic reservoir.
Nature 636, 172-181 (2024).
https://doi.org:10.1038/s41586-024-08163-9

20250520 Pre Journal Club
発表者：上野　楓実
Yao, Z. et al.
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects.
Bone Res 12, 52 (2024).
https://doi.org:10.1038/s41413-024-00352-6
Koh, B. I. et al.
Adult skull bone marrow is an expanding and resilient haematopoietic reservoir.
Nature 636, 172-181 (2024).
https://doi.org:10.1038/s41586-024-08163-9
Chen, L. et al.
Attenuation of Alzheimer's brain pathology in 5XFAD mice by PTH(1-34), a peptide of parathyroid hormone.
Alzheimers Res Ther 15, 53 (2023).
https://doi.org:10.1186/s13195-023-01202-z

20250513 Journal Club
発表者：高田健太郎 （理学院自然史科学専攻　小林快次教授研究室）
Walter, J. D. et al.
Expanded phylogeny elucidates Deinosuchus relationships, crocodylian osmoregulation and body-size evolution.
Commun Biol 8, 611 (2025).
https://doi.org:10.1038/s42003-025-07653-4

20250422 Journal Club
発表者：飯村　忠浩
Zhang, L. et al.
Bidirectional control of parathyroid hormone and bone mass by subfornical organ.
Neuron 111, 1914-1932 e1916 (2023).
https://doi.org:10.1016/j.neuron.2023.03.030

20250415 Pre Journal Club
発表者：渡辺　陽久
Zhao, L., Liu, S., Peng, Y. & Zhang, J.
Lamc1 promotes osteogenic differentiation and inhibits adipogenic differentiation of bone marrow-derived mesenchymal stem cells.
Sci Rep 14, 19592 (2024).
https://doi.org:10.1038/s41598-024-69629-4
Hou, J. et al.
Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence.
Nat Aging 4, 1562-1581 (2024).
https://doi.org:10.1038/s43587-024-00694-0
Ambrosi, T. H. et al.
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites.
Cell Stem Cell 32, 811-823 e811 (2025).
https://doi.org:10.1016/j.stem.2025.02.013

20250408 Journal Club
発表者：西本　慎之介
Nakano-Kobayashi, A., Canela, A., Yoshihara, T. & Hagiwara, M.
Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway.
Proc Natl Acad Sci U S A 120, e2303809120 (2023).
https://doi.org:10.1073/pnas.2303809120