研究業績

英語論文

(*corresponding author)(§=equally contribution)

2023

  1. Tsumita T §,Takeda R §, Maishi N, Hida Y, Sasaki M, Orba Y, Sato A, Toba S, Ito W, Teshirogi T, Sakurai Y, Iba T, Naito H, Ando H, Watanabe H, Mizuno A, Nakanishi T, Matsuda A, Zixiao R, Lee JW,Iimura T,  Sawa H*,  Hida K*: Viral uptake and pathophysiology of the lung endothelial cells in age-associated severe SARS-CoV-2 infection models, Aging Cell, in press
  2. Kikuchi H, Maishi N,  YU L, Jia Z, Li C, Sato M, Takeda R, Ishizuka K, Hida Y, Shinohara N and *Hida K,: Low-dose metronomic cisplatin as an antiangiogenic and anti-inflammatory strategy for cancer, Brit J Cancer, doi:10.1038/s41416-023-02498-2
    北海道大学プレスリリース「シスプラチンの低用量維持投与は抗腫瘍効果を増強する~抗がん剤による炎症性変化を抑え、腫瘍血管を正常化する新たな治療法を提案~
  3. Yu Li, Hong Y, Maishi N, Yanagawa Matsuda A, Hida Y, Hasebe A,Kitagawa Y, Hida K*: Oral bacterium Streptococcus mutans promotes tumor metastasis via thrombosis formation, Cancer Sci, 115(2), 648-659,2024, doi: 10.1111/cas.16010
    北海道大学プレスリリース「口腔内細菌による血栓症はがんの転移を促進する~がん患者の口腔清掃の重要性を明らかに~
  4. Morimoto M, Maishi N, Tsumita T, Alam MT, Kikuchi H, Hida Y, Yoshioka Y, Ochiya T, Annan DA, Takeda R, Kitagawa Y, Hida K: miR-1246 in tumor extracellular vesicles promotes metastasis via increased tumor cell adhesion and endothelial cell barrier destruction, Front. Oncol, 13 , doi:10.3389/fonc.2023.973871/
  5. Sato M, Maishi N, Hida Y, Yanagawa-Matsuda A, Alam MT, Sakakibara-Konishi J, Nam JM, Onodera Y, Konno S, Hida K: Angiogenic inhibitor pre-administration improves the therapeutic effects of immunotherapy, Cancer Med,  doi: 10.1002/cam4.5696

2022

  1. Nurina Febriyanti Ayuningtyas, Chanbora Chea, Toshinori Ando, Karina Erda Saninggar, Keiji Tanimoto, Toshihiro Inubushi, Nako Maishi, Kyoko Hida, Masanobu Shindo, Mutsumi Miyauchi *, Takashi Takata *: Bovine lactoferrin suppresses tumor angiogenesis through NF-κB pathway inhibition by binding to TRAF6, Pharmaceutics, 2022 
  2. Furumido J, Maishi N, Yanagawa-Matsuda A, Kikuchi H, Matsumoto R, Osawa, T, Abe T, ; Matsuno Y, Shinohara N, Hida Y, Hida K: Stroma Biglycan Expression can be a Prognostic Factor in Prostate Cancers, Int J Urol, 2022 (IF=3.011)in press
  3. Takeda R, Sawa H, Sasaki M, Orba Y, Maishi N, Tsumita T, Ushijima6 N, Hida Y, Sano H, Kitagawa Y & Hida K: Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2, Sci Rep,  (2022) 12:14050
  4. Yu L, Maishi N, Akahori E, Hasebe A, Takeda R, Yanagawa-Matsuda A, Hida Y, Nam Jin-Min, Onodera Y, Kitagawa Y, Hida K: The oral bacterium Streptococcus mutans  promotes tumor metastasis by inducing vascular inflammation, Cancer Sci, 2022;00:1-15
  5. TsumitaT, Maishi N, Annan DA, Alam MT, Matsuda A, Onodera Y, Nam JM, Hida Y, Hida K: The oxidized-LDL/LOX-1 axis in tumor endothelial cells enhances metastasis by recruiting neutrophils and cancer cells, Int. J. Cancer, 151(6), 944-956, 2022 (selected as a cover) 
  6. Maishi N, Sakurai Y, Hatakeyama H, Umeyama Y, Nakamura T, Endo R, Alam MT, Li C, Annan DA, Kikuchi H, Morimoto H, Morimoto M, Akiyama K, Ohga N, Hida Y, Harashima H, *Hida K: Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell-specific liposomal siRNA delivery system, Cancer Sci.113(5):1855-1867. May 2022

2021

  1. Nishiyama K, Takahashi K, Fukuyama M, Kasuya M, Imai A, Usukura T, Maishi N, Maeki M, Ishida A, Tani H, Hida K, Shigemura K, Hibara A, Tokeshi M: Facile and rapid detection of SARS-CoV-2 antibody based on a noncompetitive fluorescence polarization immunoassay in human serum samples, Biosens Bioelectron, (2021) 190:113414.
  2. Torii C, Maishi N, Kawamoto T, Morimoto M, Akiyama K, Yoshioka Y, Minami T, Tsumita T, Alam MT, Ochiya T, Hida Y, *Hida K: miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells, Sci Rep, (2021) 11:13502
  3. Li C, Maishi N, Annan DA, Young MF, Morimoto H, Morimoto M, Nam JM, Hida Y, *Hida K: Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy, Breast Cancer Res, (2021) 23:51
  4. Yanagiya M, Dawood RIH, Maishi N, Hida Y, Torii C, Annan DA, Kikuchi H, Yanagawa Matsuda A, Kitamura T, Tei K, Shindoh M, Tanaka S, Kitagawa Y, *Hida K: Correlation between endothelial chemokine receptor 7CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma, Pathol Int, 2021:71:383–391
  5. Morimoto H, Hida Y, Maishi N, Nishihara H, Hatanaka Y, Li C, Matsuno Y, Nakamura T, Hirano S, *Hida K: Biglycan, tumor endothelial cell secreting proteoglycan, as possible biomarker for lung cancer, Thorac Cancer, 12(9), 1347-1357, 2021

2020

  1. Hiradate R, Khalil IA, Matsuda A, Sasaki M, Hida K, Harashima H: A novel dual-targeted rosiglitazone-loaded nanoparticle for the prevention of diet-induced obesity via the browning of white adipose tissue, J Controlled Release, 329(10), 665-675, 2020
  2. Kikuchi H, Maishi N, Dorcas A. Annan, Mohammad Towfik Alam, Randa Ibrahim Hassan Dawood, Sato M, Morimoto M, Takeda R, Ishizuka K, Matsumoto R, Akino T, Tsuchiya K, Abe T, Osawa T, Miyajima N, Maruyama S, Harabayashi T, Azuma M, Yamashiro K, Ameda K, Kashiwagi A, Matsuno Y, Hida Y, Shinohara N and *Hida K: Chemotherapy-induced IL-8 upregulates MDR1/ABCB1 in tumor blood vessels and results in unfavorable outcome,  doi:10.1158/0008-5472.CAN-19-3791 Cancer Res, 80(14)
  3. Habiba U, Hossain E, Yanagawa-Matsuda A, Chowdhury A.F.M.A, Tsuda M, Zaman A.U, Tanaka S, Higashino F. Cisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus. Cancers 12(4), 809.
  4. Mikawa Y, Towfik Alam M, Hossain E, Yanagawa-Matsuda A, Kitamura T, Yasuda M, Habiba U, Ahmed I, Kitagawa Y, Shindoh M, Higashino F:  Conditionally Replicative Adenovirus Controlled by the Stabilization System of AU-rich Elements Containing mRNA. Cancers 12(5), 1205; 2051205. (2020).
  5. Hossain E, Habiba U, Yanagawa-Matsuda A, Alam A, Ahmed I, Alam MT, Yasuda M, Higashino F: Advantages of Using Paclitaxel in Combination with Oncolytic Adenovirus Utilizing RNA Destabilization Mechanism. Cancers 12(5), 1210 (2020).
  6. Ahmed I, Towfik Alam M, Yanagawa-Matsuda A, Hossain E, Kitamura T, Minowa K, Higashino F: Enhanced oncolytic activity of E4orf6-deficient adenovirus by facilitating nuclear export of HuR. Biochem Biophys Res Commun. 529(2):494-499 (2020).
  7. Yoshimatsu, Yasuhiro, Wakabayashi I, Kimuro S, Takahashi N, Takahashi K, Kobayashi M, Maishi N, Inoue K, Hida K, Miyazono K, Watabe T:TNF-α enhances TGF-β-induced endothelial-to-mesenchymal transition via TGF-β signal augmentation, Cancer Sci, 111(7), 2385-2399.

2019

  1. Annan DA, Maishi N, Soga T, Dawood RIH, Li C, Kikuchi H, Hojo T, Morimoto M, Kitamura T, Alam MT, Minowa K, Shinohara N, Nam JM, Hida Y and *Hida K:Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment, Cell Commun. Signal., 17, 169, 2019
  2. Maishi N.§, Kikuchi. H§, Sato M, Nagao-Kitamoto H, Annan DA, Baba S, Hojo T, Yanagiya M, Ohba Y, Ishii G, Masutomi K, Shinohara N, Hida Y and *Hida K: Development of immortalized human tumor endothelial cells from renal cancer, Int. J. Mol. Sci., equally contributed, 20, 4595, 2019
  3. Toshihiro Kushibiki, Toru Nakamura, Masumi Tsuda, Takahiro Tsuchikawa, Koji Hontani, Kazuho Inoko, Mizuna Takahashi, Toshimichi Asano, Keisuke Okamura, Soichi Murakami, Yo Kurashima, Yuma Ebihara, Takehiro Noji, Yoshitsugu Nakanishi, Kimitaka Tanaka, Nako Maishi, Katsunori Sasaki, Woong-Ryeon Park, Toshiaki Shichinohe, Kyoko Hida, Shinya Tanaka, and Satoshi Hirano:Role of dimerized C16orf74 in aggressive pancreatic cancer: A novel therapeutic target, Mol Cancer Ther, 19(1):187-198, 2019
  4. Ahmed Y AlBaloul, Yusuke Sato, Nako Maishi, Kyoko Hida, Hideyoshi Harashima:Two modes of toxicity of lipid nanoparticles containing a pH-sensitive cationic lipid on human A375 and A375-SM melanoma cell lines, BPB Reports, in press
  5. Sakurai Y., Kato A., Hida Y., Hamada J., Maishi N., Hida K., Harashima H.:Synergistic enhancement of cellular uptake with CD44-expressing malignant pleural mesothelioma by combining cationic liposome and hyaluronic acid-lipid conjugate, J Pharm Sci,  108, 3218-3224, 2019
  6. Yuichi Akatsu, Naoya Takahashi, Yasuhiro Yoshimatsu, Shiori Kimuro, Tomoki Muramatsu, Akihiro Katsura1, Nako Maishi, Hiroshi I. Suzuki, Johji Inazawa, Kyoko Hida, Kohei Miyazono, and Tetsuro Watabe:Fibroblast growth factor signals regulate transforming growth factor-β-induced endothelial-to-myofibroblast transition of tumor endothelial cells via Elk1, Molecular Oncology, 13(8), 1706-1724, 2019

2017

  1. *Hida K §, Kawamoto T §, Maishi N, Morimoto M, Akiyama K, Ohga N, Shindoh M, Shinohara N, Hida Y:miR-145 Promoted Anoikis Resistance in Tumor Endothelial Cells, J Biochem, 162(2), 81-84
  2. Hojo T §, Maishi N.§, Alam MT, Akiyama K, Ohga N, Shindoh M, Hida Y, Minowa K, Fujisawa T, *Hida K:ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells, Oncotarget, 8(28), 45484-45495, 2017
  3. Torii C, Hida Y, Shindoh M, Akiyama K, Ohga N, Maishi N, Ohiro Y, Ono M, Totsuka Y, Kitagawa Y, Tei K, Sato Y, *Hida K:Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma, Anticancer Res, 37(3), 1219-1225, 2017
  4. *Hida K, Maishi N, Annan DA, Kondoh M, Hojo T, Umma Habiba, Ohga N, Ishikawa K, Sato M, Torii C, Yanagiya M, Morimoto M, Hida Y, Shindoh M:Aneuploidy of murine immortalized endothelial cell line, MS1,J Oral Biosci,59 (2017), 50-54, 2017
  5. Habiba U, *Hida K, Kitamura T, Yanagawa Matsuda A, Higashino F, Ito M Y, Ohiro Y, Totsuka Y, Shindoh M: ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia, Oncol Lett, 13(1), 321-328, 2017

2016

  1. *Hida K, Maishi N, Kawamoto T, Akiyama K, Ohga N, Hida Y, Yamada K, Hojo T, Kikuchi H, Sato M, Torii C, Shinohara N, Shindoh M:Tumor endothelial cells express high pentraxin 3 levels, Pathol Int, 66(12), 687-694, 2016
  2. *Hida K, Maishi N, Torii C, Yanagiya M, Annan DA, Morimoto M, Alam MT:Comparison of characteristics of mouse immortalized normal endothelial cells, MS1 and primary cultured endothelial cells, Hokkaido Journal of Dental Science, 37(1), 40-48, 2016
  3. Maishi N, Ohba Y, Akiyama K, Ohga N, Hamada J, Nagao-Kitamoto H, Alam MT, Yamamoto K, Kawamoto T, Inoue N, Taketomi A, Shindoh M, Hida Y, *Hida K:Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan, Sci Rep, 6, 28039〔PDF
  4. Shahrabi-Farahani S, Gallottini M, Martins F, Li E, Mudge DR, Nakayama H, Hida K, Panigrahy D, D’Amore PA, Bielenberg DR: Neuropilin 1 Receptor is Upregulated in Dysplastic Epithelium and Oral Squamous Cell Carcinoma, Am J Pathol, 186(4), 1055-1064, 2016

2015

  1. Yamada K§, Maishi N §, Akiyama K, Alam MT, Ohga N, Kawamoto T, Shindoh M, Takahashi N, Kamiyama T, Hida Y, Taketomi A and *Hida K:CXCL 12-CXCR7 axis is important for tumor endothelial cell angiogenic property, Int J Cancer 137(12), 2825-2836 2015 (selected as a cover)
  2. Matsumoto R, Tsuda M, Wang L; Maishi N, Abe T, Kimura T, Tanino M, Nishihara H, Hida K, Ohba Y, Shinohara N, Nonomura K, Tanaka S,:Adaptor protein CRK induces epithelial–mesenchymal transition and metastasis of bladder cancer cells through HGF/c-Met feedback loop, Cancer Sci, 106(6), 709-717
  3. Akiyama K, Ohga N, Hida Y, Maishi N, Ohba Y, Alam MT, Kawamoto T, Ohmura H, Yamada K, Torii C, Shindoh M and *Hida K:Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic activity,Am J Pathol,185(2), 572-580, 2015

2014

  1. Kibria G, Hatakeyama H,Akiyama K, Hida K and Harashima H:Comparative Study of the Sensitivities of Cancer Cells to Doxorubicin, and Relationships between the Effect of the Drug-Efflux Pump P-gp,Biol. Pharm. Bull.37(12), 1926–1935, 2014
  2. Ohmura-Kakutani H.§, Akiyama K, §Maishi N, Ohga N, Hida Y, Kawamoto T, Iida J, Shindoh M, Tsuchiya K, Shinohara N, *Hida K:Identification of Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity and a Highly Angiogenic Phenotype, PLoS ONE,  9(12):e113910, 2014
  3. Akhter A, Hayashi Y, Sakurai Y, Ohga N, Hida K, Harashima H:Ligand density at the surface of a nanoparticle and different uptake mechanism: Two important factors for successful siRNA delivery to liver endothelial cells, Int J Pharm,475 (1-2):227-237, 2014
  4. Ara MN, Matsuda T, Hyodo M, Sakurai Y, Ohga N, Hida K:Construction of an aptamer modified liposomal system targeted to tumor endothelial cells, Bio Pharm Bull, 37(11):1742-9, 2014
  5. Alam MT.§, Nagao-Kitamoto H.§, Ohga N, Akiyama K, Maishi N,  Kawamoto T, Shinohara N, Taketomi A, Shindoh M, Hida Y and *Hida K:Suprabasin as a novel tumor endothelial cell marker, Cancer Sci, 105(12), 1533–1540, 2014
  6. Ara MN, Matsuda T, Hyodo M, Sakurai Y, Hatakeyama H, Ohga N, Hida K, Harashima H:An aptamer ligand based liposomal nanocarrier system that targets tumor endothelial cells,Biomaterials, 35(25), 7110-7120, 2014
  7. Ara MN, Hyodo M, Ohga N, Akiyama K, Hida K, Hida Y, Shinohara N, Harashima H:Identification and expression of troponin T, a new marker on the surface of cultured tumor endothelial cells by aptamer ligand, Cancer Med, 3(4), 825-834, 2014
  8. Otsubo T, Hida Y, Ohga N, Sato H, Kai T, Matsuki Y, Takasu H, Akiyama K, Maishi N, Kawamoto T, Shinohara N, Nonomura K, *Hida K:Identification of Novel Targets for Antiangiogenic Therapy by Comparing the Gene Expressions of Tumor and Normal Endothelial Cells, Cancer Sci, 105(5), 560-567, 2014
  9. Habiba U, Kitamura T, Yanagawa-Matsuda A, Hida K, Higashino F, Ohiro Y, Totsuka Y and Shindoh M:Cytoplasmic expression of HuR may be a valuable diagnostic tool for determining the potential for malignant transformation of oral verrucous borderline lesions, Oncol Rep, 31(4), 1547-1554, 2014
  10. Sakurai Y, Hatakeyama H, Sato Y, Hyodo M, Akita H,Ohga N, Hida K, Harashima H:RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system, J Control Release, 173(10), 110-118, 2014

2013

  1. Kondoh M §, Ohga N §, Akiyama K §, Hida Y, Maishi N, Towfik AM, Inoue N, Shindoh M and *Hida K:Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment, PLoS ONE, 8(11), e80349, 2013
  2. Akhter A, Hayashi Y, Sakurai Y, Ohga N, Hida K, Harashima H:A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence,Int J Pharm,456(1),195-201, 2013
  3. Osawa T, Ohga N, Akiyama K, Hida Y, Kitayama K, Kawamoto T, Yamamoto K, Maishi N, Kondoh M, Onodera Y, Fujie M, Nonomura K, Shindoh M and *Hida K : Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis, Br J Cancer, 109(8), 2237-2247, 2013
  4. Maishi N, Kawamoto T, Ohga N,Yamad K, Akiyama K, Yamamoto K , Osawa T, Hida Y and *Hida K.: Application of POLARIC™ fluorophores in an in vivo tumor model, Oncol Rep, 30(4), 1695-1700, 2013
  5. Kibria G, Hatakeyama H, Ohga N. Hida K, Harashima H:The effect of liposomal size on the targeted delivery of doxorubicin to Integrin alpha v beta 3-expressing tumor endothelial cells, Biomaterials, 34(22), 5617-5627, 2013
  6. Nagamine K, Kitamura T, Yanagawa -Matsuda A, Ohiro Y, Tei K, Hida K, Higashino F, Totsuka Y and Shindoh M: Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma, Oncol Rep, 29(6), 2114-2118, 2013
  7. Yamada Y, Hashida M, Hayashi Y, Tabata M, Hyodo M, Ara MN, Ohga N, Hida K, Harashima H:An approach to transgene expression in liver endothelial cells using a liposome-based gene vector coated with hyaluronic acid, J Pharm Sci,102(9), 3119-3127, 2013
  8. Akiyama K, Ohga N, Maishi N, Hida Y, Kitayama K, Kawamoto T, Osawa T, Suzuki Y, Shinohara N, Nonomura K, Shindoh M, *Hida K : The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma, Pathol Int,63(1), 37-44, 2013 〔PDF〕

2012

  1. Ara MN, Hyodo M, Ohga N, Hida K, Harashima H: Development of a novel DNA aptamer ligand against primary cultured tumor endothelial cells, PLoS ONE, 7(12), e50174, 2012
  2. Takara K, Hatakeyama H, Kibria G, Ohga N, Hida K, Harashima H:Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise foruse in drug-resistant cancer therapy, J Controlled Release, 162(1), 225-232, 2012
  3. Osawa T, Ohga N, Hida Y, Kitayama K, Akiyama K, Onodera Y, Fujie M, Shinohara N, Nonomura K, Shindoh M, *Hida K: Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner, Cancer Sci, 103(6), 1038-1044, 2012
  4. Kawamoto T, Ohga N, Akiyama K, Hirata N, Kitahara S, Maishi N, Osawa T, Yamamoto K, Kondoh M, Shindoh M, Hida Y, *Hida K: Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis, PLoS ONE 7(3) :e34045, 2012
  5. Yamamoto K, Ohga N, Hida Y, Maishi N, Kawamoto T, Kitayama K, Akiyama K, Osawa T. Kondoh M, Matsuda K, Onodera Y, Fujie M, Kaga K, Hirano S, Shinohara N., Shindoh M., *Hida K.: Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells, Br J Cancer, 106(6), 1214-1223, 2012
  6. Maishi N, Ohga N, Hida Y, Akiyama K, Kitayama K, Osawa T, Onodera Y, Nonomura K, Shinohara N, Shindoh M, *Hida K : CXCR7 : A novel tumor endothelial marker in renal cell carcinoma, Pathol Int, 62(5), 309-317, 2012
  7. Ohga N, Ishikawa S, Maishi N, Akiyama K, Hida Y, Kawamoto T, Sadamoto Y, Osawa T, Yamamoto K, Kondoh M, Ohmura H, Shinohara N, Nonomura K, Shindoh M, *Hida K:Heterogeneity of Tumor Endothelial Cells: Comparison between Tumor Endothelial Cells Isolated from Highly Metastatic and Low Metastatic Tumors, Am J Pathol, 180(3), 1294-1307, 2012
  8. Akiyama K, Ohga N, Hida Y, Kawamoto T, Sadamoto Y, Ishikawa S, Maishi N, Akino T, Kondoh M, Matsuda A, Inoue N, Shindoh M and *Hida K.: Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment, Am J Pathol, 180(3), 1283-1293, 2012

2011

  1. Kibria G, Hatakeyama H, Ohga N, Hida K, Harashima H: Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery, J Controlled Release, 153(2), 141-148, 2011
  2. Muraki C §, Ohga N§, Hida Y, Nishihara H, Kato Y, Tsuchiya K, Matsuda K, Totsuka Y, Shindoh M and *Hida K.§: Cyclooxygenase- Int J Cancer,130(1), 59-72, 2011
  3. Kurosu T, Ohga N, Hida Y, Maishi N, Akiyama K, Kakuguchi W, Kuroshima T, Kondo M, Akino T, Totsuka Y, Shindoh M, Higashino F and *Hida K.: HuR keeps an angiogenic switch on by stabilizing mRNA of VEGF and COX-2 in tumor endothelium,Br J Cancer, 104(5), 819-829, 2011 〔PDF〕
  4. Nitta Y, Hida K, Kitamura T, Higashino F, Ohga N, Fukushima K, Shindoh M: Phenotype of tumor lymphatic vessels is a prognostic factor in human tongue squamous cell carcinoma, Oncol Lett, 2(1), 79-83, 2011

2010

  1. Takara K, Hatakeyama H, Ohga N, Hida K*, Harashima H: Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake,Int J Pharm, 396(1-2), 143-148, 2010
  2. Kajimoto K, Hossen MN, Hida K, Ohga N, Akita H, Hyodo M, Hida Y and Harashima H: Isolation and Culture of Microvascular Endothelial Cells from Murine Inguinal and Epididymal Adipose Tissue, J Immunol Methods, 357(1-2),43-50, 2010
  3. Matsuda K §, Ohga N §, Hida Y, Muraki C, Kurosu T, Tsuchiya K, Akino T, Shih SC, Totsuka Y, Klagsbrun M, Shindoh M and *Hida K:Isolated tumor endothelial cells maintain specific character during long-term culture, Biochem Biophys Res Commun, 394(4), 947- 954, 2010
  4. Suzuki Y, Ohga N, Morishita Y, Hida K, Miyazono K, and Watabe T: BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo, J Cell Sci, 123(10), 1684-1692, 2010
  5. Tsuchiya K, *Hida K, Hida Y, Muraki C, Ohga N, Kondo T, Miseki T, Nakagawa K, Shindoh M, Harabayashi T, Shinohara N, Nonomura K and Kobayashi M: Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progernitor mobilization, Int J Oncol, 36(6), 1379-1386, 2010

2009

  1. Ohga N,*Hida K, Hida Y, Muraki C, Tsuchiya K, Matsuda K, Ohiro Y, Totsuka Y and Shindoh M: Inhibitory Effects ofEpigallocatechin-3 Gallate, a Polyphenol in Green Tea, on Tumor-Associated Endothelial Cells and Endothelial Progenitor Cells. Cancer Sci, 100(10), 1963-1970, 2009
  2. Akino T., *Hida K., Hida Y., Tsuchiya K., Freedman D., Muraki C., Ohga N., Matsuda K., Akiyama K., Harabayashi T., Shinohara N., Nonomura K., Klagsbrun M. and Shindoh M.: Cytogenetic Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumor. Am J Pathol,175(6), 2657-2667, 2009 〔PDF〕
  3. Tanaka S, Kitamura T, Higashino F, Hida K., Ohiro Y, Ono M, Kobayashi M, Totsuka Y, Shindoh M: Pim-1 activates cell motility that induces malignant phenotype of tongue squamous cell carcinoma. Mol Med Rep, 2(2):313-318, 2009.

2008年以前

  1. Dudley AC, Shih SC, Cliffe AR, Hida K and Klagsbrun M: Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine. Br J Cancer, 99(1), 118-125, 2008.
  2. Hata H, Kitamura T, Higashino F, Hida K, Yoshida K, Ohiro Y, Totsuka Y, Kitagawa Y and Shindoh M: Expression of E1AF, and ets-oncogene transcription factor, expression highly correlates with malignant phenotype of malignant melanoma through upregulating membrane-type-1 matrix metalloproteinase gene. Oncol Rep, 19(5), 1093-1098, 2008
  3. Amin DN, Hida K, Bielenberg DR and Klagsbrun M:Expression of epidermal growth factor (EGF) receptor but not ErbB3 in Tumor endothelial cells coincides with responsiveness to EGF and sensitivity to EGFR kinase inhibitors. Cancer Res., 66 (4), 2173-2180, 2006
  4. Hida K, Hida Y, Amin D, Flint A, Panigrahy D, Morton C and Klagsbrun M:Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res., 64(22), 8249-8255, 2004 〔PDF〕
  5. Shindoh M, Adachi M, Higashino F, Yasuda M, Hida K., Nishioka K, Takayama S, Reed JC, Imai K, Totsuka Y and Kohgo T: BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma. Oral Oncol, 36(5), 444-449, 2000
  6. Hanzawa M, Shindoh M, Higashino F, Yasuda M, Hida K, Kohgo T, Nakamura M, Notani K, Totsuka Y, Yoshida K and Fujinaga K: Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma (SCC) cell invasion by activating matrix metalloproteinase genes. Carcinogenesis, 21(6), 1079-1085, 2000
  7. Hida K, Shindoh M, Yoshida K, Yasuda M, Hanzawa M, Funaoka K, Kohgo T, Amemiya A,  Totsuka Y and Fujinaga K: Antisense E1AF transfection restrains oral cancer invasion by reducing MMPs activities. Am J Pathol, 150, 2125-2132, 1997
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