Research

Recent Publications

  • Original Article (2001-2016):

    (2016)
    45. Sato M, Suzuki T, Kawano M, Tamura M.
    Circulating osteocyte-derived exosomes contain miRNAs which are enriched in exosomes from MLO-Y4 cells. Biomed Rep. in press

  • 44. Sato M, Tamura M.
    Noncanonical Wnt signaling in stromal cells regulates B-lymphogenesis through interleukin-7 expression.
    Biochemistry and Biophysics Reports, 6:179-184, 2016.
    doi:10.1016/j.bbrep.2016.03.017
  • 43. Sakisaka Y, Kanaya S, Nakamura T, Tamura M, Shimauchi H, Nemoto E.
    p38 MAP kinase is required for Wnt3a-mediated osterix expression independently of Wnt-LRP5/6-GSK3β signaling axis in dental follicle cells.
    Biochem Biophys Res Commun. 2016 Sep 16;478(2):527-32. PMID: 27450807
    doi: 10.1016/j.bbrc.2016.07.076
  • 42. Ukita M, Yamaguchi T, Ohata N, Tamura M
    Sclerostin enhances adipocyte differentiation in 3T3-L1 cells.
    J Cell Biochem. 2016 Jun;117(6):1419-28. PMID: 26553151
    doi: 10.1002/jcb.25432
  • 41. Nemoto E, Sakisaka Y, Tsuchiya M, Tamura M, Nakamura T, Kanaya S, Shimonishi M, Shimauchi H.
    Wnt3a signaling induces murine dental follicle cells to differentiate into cementoblastic/osteoblastic cells via an osterix-dependent pathway.
    J Periodontal Res. 2016 Apr;51(2):164-74. PMID: 26095156
    doi:10.1111/jre.12294
  • (2015)
    40. Tamura M, Kawano M, Sato M, Nashimoto M.
    Involvement of an intracellular vesicular transport process in naked-sgRNA-mediated TRUE gene silencing.
    Mol Med Rep. 2015, in press
  • 39. Sakisaka Y, Tsuchiya M, Nakamura T, Tamura M, Shimauchi H, Nemoto E.
    Wnt5a attenuates canonical Wnt-induced alkaline phosphatase expression in dental follicle cells.
    Exp Cell Res. 2015 Aug 1;336(1):85-93. PMID: 26112214
    doi:10.1016/j.yexcr.2015.06.013
  • 38. Ninomiya S, Kawano M, Abe T, Ishikawa T, Takahashi M, Tamura M, Takahashi Y, Nashimoto M.
    Potential small guide RNAs for tRNase ZL from human plasma, peripheral blood mononuclear cells, and cultured cell lines.
    PLoS One. 2015 Mar 2;10(3):e0118631. PMID: 25730316
    doi: 10.1371/journal.pone.0118631
  • (2014)
    37. Iizuka S, Oridate N, Nashimoto M, Fukuda S, Tamura M.
    Growth Inhibition of Head and Neck Squamous Cell Carcinoma Cells by sgRNA Targeting the Cyclin D1 mRNA Based on TRUE Gene Silencing.
    PLoS One. 2014 Dec 1;9(12):e114121. PMID: 25437003
    doi: 10.1371/journal.pone.0114121
  • 36. Takahashi M, Elbarbary RA, Watanabe N, Goto A, Kamiya D, Watabe Y, Uchiyama T, Narita M, Takahashi M, Takahashi Y, Ishihara N, Miyazawa T, Yoshida T, Kawano M, Tamura M, Nashimoto M.
    Screening of a heptamer-type sgRNA library for therapeutic agents against hematological malignancies.
    Leuk Res. 2014 Jul;38(7):808-15. PMID: 24768135
    doi: 10.1016/j.leukres.2014.03.021
  • (2013)
    35. Tamura M, Uyama M, Sugiyama Y, Sato M.
    Canonical Wnt signaling activates miR-34 expression during osteoblastic differentiation.
    Mol Med Rep. 2013 Dec;8(6):1807-11. PMID: 24100761
    doi: 10.3892/mmr.2013.1713
  • 34. Kurebayashi N, Sato M, Fujisawa T, Fukushima K, Tamura M.
    Regulation of neuropeptide Y Y1 receptor expression by bone morphogenetic protein 2 in C2C12 myoblasts.
    Biochem Biophys Res Commun. 2013 Oct 4;439(4):506-510. PMID: 24025680
    doi: 10.1016/j.bbrc.2013.09.014
  • 33. Uyama M, Kawanami M, Tamura M.
    Wasf2: a novel target of intermittent PTH administration.
    Int J Mol Med. 2013 May;31(5):1243-7. PMID: 23525371
    doi:10.3892/ijmm.2013.1315.
  • 32. Takahashi M, Elbarbary RA, Nakashima A, Abe M, Watanabe N, Narita M, Takahashi M, Tamura M, Yoshida T, Nashimoto M.
    A naked RNA heptamer targeting the human Bcl-2 mRNA induces apoptosis of HL-60 leukemia cells.
    Cancer Lett. 2013 Jan 28;328(2):362-8. PMID: 23092557
    doi:10.1016/j.canlet.2012.10.016
  • (2012)
    31. Wada Y, Mizuno M, Nodasaka Y, Tamura M.
    The effect of enamel matrix derivative on spreading, proliferation, and differentiation of osteoblasts cultured on zirconia.
    Int J Oral Maxillofac Implants. 2012 Jul-Aug;27(4):849-58. PMID: 22848887
  • 30. Uyama M, Sato MM, Kawanami M, Tamura M.
    Regulation of osteoblastic differentiation by the proteasome inhibitor bortezomib.
    Genes Cells. 2012 Jul;17(7):548-58. PMID:22702336
    doi: 10.1111/j.1365-2443.2012.01611.x
  • 29. Nemoto E, Ebe Y, Kanaya S, Tsuchiya M, Nakamura T, Tamura M, Shimauchi H.
    Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis.
    Biochem Biophys Res Commun.2012 Jun 15;422(4):627-32. PMID:22609204
    doi:10.1016/j.bbrc.2012.05.039
  • 28. Takahashi M, Elbarbary RA, Abe M, Sato M, Yoshida T, Yamada Y, Tamura M, Nashimoto M.
    Elimination of specific miRNAs by TRUE gene silencing.
    PLoS One. 2012;7(6):e38496. Epub 2012 Jun 4. PMID: 22675569
    doi:10.1371/journal.pone.0038496
  • (2011)
    27. Sano T, Takahashi Y, Takaku H, Tamura M. Nashimoto M.
    Expanding the utility of heptamer-type sgRNA for TRUE gene silencing.
    Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):427-32. PMID: 22142845
    doi:10.1016/j.bbrc.2011.11.091
  • 26. Tamura M, Sato MM, Nashimoto M.
    Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells.
    Int J Biochem Cell Biol 2011 May;43(5):760-7. PMID:21296678
    doi:10.1016/j.biocel.2011.01.021
  • (2010)
    25. Li M, Seki Y, Freitas PH, Nagata M, Kojima T, Sultana S, Ubaidus S, Maeda T, Shimomura J, Henderson JE, Tamura M, Oda K, Liu Z, Guo Y, Suzuki R, Yamamoto T, Takagi R, Amizuka N.
    FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line.
    J Electron Microsc (Tokyo). 2010;59(3):227-36. PMID:20356821
    doi:10.1093/jmicro/dfq002
  • 24. Ohkubo N, Ishisaki A, Iizuka T, Tamura M, Kitagawa Y.
    Vascular cell-like potential of undifferentiated ligament fibroblasts to construct vascular cell-specific marker-positive blood vessel structures in a PI3K-activation-dependent manner.
    J Vasc Res, 2010.Aug;47(5):369-383. PMID:20110728
    doi: 10.1159/000277724
  • (2009)
    23. Sato MM, Nashimoto M, Katagiri T, Yawaka Y, Tamura M.
    Bone morphogenetic protein-2 down-regulates miR-206 expression by blocking its maturation process.
    Biochem Biophys Res Commun. 2009 May 22;383(1):125-9. PMID:19341710
    doi:10.1016/j.bbrc.2009.03.142
  • 22. Nemoto, E., Koshikawa, Y., Kanaya, S., Tsuchiya, M., Tamura, M., Somerman, MJ, Shimauchi, H.
    Wnt signaling inhibits cementoblast differentiation and promotes proliferation.
    Bone, 2009 May;44(5):805-12. PMID:19442631
    doi:10.1016/j.bone.2008.12.029
  • 21. Wada Y, Mizuno M, Tamura M.
    Enamel matrix derivative neutralized the effect of lipopolysaccharide on osteoprotegerin and receptor activator of nuclear factor kappa B ligand expression of osteoblasts.
    Arch Oral Biol. 2009 Apr;54(4):306-12. PMID:19201394
    doi:10.1016/j.archoralbio.2009.01.004
  • 20. Shirai K, Ishisaki A, Kaku T, Tamura M, Furuichi Y.
    Multipotency of clonal cells derived from swine periodontal ligament and differential regulation by fibroblast growth factor and bone morphogenetic protein.
    J Periodontal Res. 2009 Apr;44(2):238-47. PMID:18973516
    doi: 10.1111/j.1600-0765.2008.01140.x
  • 19. Elbarbary RA, Takaku H, Tamura M, Nashimoto M.
    Inhibition of vascular endothelial growth factor expression by TRUE gene silencing.
    Biochem Biophys Res Commun. 2009 Feb 20;379(4):924-7. PMID:19135977
    doi:10.1016/j.bbrc.2008.12.173
  • 18. Sato MM, Nakashima A, Nashimoto M, Yawaka Y. and Tamura M.
    Bone morphogenetic protein-2 enhances Wnt/β-catenin signaling-induced osteoprotegerin expression.
    Genes Cells. 2009 Feb;14(2):141-53. PMID:19170762
    doi: 10.1111/j.1365-2443.2008.01258.x
  • 17. Fujisawa R, Mizuno M, Tamura M.
    Effect of dentin phosphoprotein on phosphate-induced apoptosis of odontoblast-like cells.
    Cells Tissues Organs, 2009;189(1-4):60-4. PMID:18701817
    doi: 10.1159/000151455
  • (2008)
    16. Wada Y, Mizuno M, Yamamoto E, Nambu S, Tamura M.
    The suppressive effect of enamel matrix derivative on osteocalcin gene expression of osteoblast is neutralized by an antibody against TGF-ß.
    J Periodontol. 2008 Feb;79(2):341-7. PMID:18251649
    doi:10.1902/jop.2008.070197
  • (2007)
    15. Ibi M, Ishisaki A, Yamamoto M, Wada S, Kozakai T, Nakashima A, Iida J, Takao S, Izumi Y, Yokoyama A, Tamura M.
    Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments.
    Arch Oral Biol. 2007 Oct;52(10):1002-8. PMID:17543882
    doi:10.1016/j.archoralbio.2007.04.009
  • 14. Nakashima A, Takaku H, Shibata HS, Negishi Y, Takagi M, Tamura M, Nashimoto M.
    Gene-silencing by the tRNA maturase tRNase ZL under the direction of small guide RNA.
    Gene Ther. 2007 Jan;14(1):78-85. PMID:16885998
    doi:10.1038/sj.gt.3302841
  • (2006)
    13. Nakashima A, Tamura M.
    Regulation of matrix metalloproteinase-13 and tissue inhibitor of matrix metalloproteinase-1 gene expression by Wnt3a and bone morphogenetic protein-2 in osteoblastic differentiation.
    Front Biosci. 2006 May 1;11:1667-78. PMID:16368545
    doi:10.2741/1912
  • (2005)
    12. Nakashima A, Katagiri T, Tamura M.
    Cross-talk between Wnt and bone morphogenetic protein (BMP)- 2 signalling in differentiation pathway of C2C12 myoblasts.
    J Biol Chem. 2005 Nov 11;280(45):37660-8. PMID:16150699
    doi:10.1074/jbc.M504612200
  • (2004)
    11. Takita H, Vehof JW, Jansen JA, Yamamoto M, Tabata Y, Tamura M, Kuboki Y.
    　　　　　　　　　　　　　　　　　Carrier dependent cell differentiation of bone morphogenetic protein-2 induced osteogenesis and chondrogenesis during the early implantation stage in rats.
    J Biomed Mater Res A. 2004 Oct 1;71(1):181-9. PMID:15368268
    doi:10.1002/jbm.a.30152
  • 10. Zhang GX, Mizuno M, Tsuji K, Tamura M.
    Regulation of mRNA expression of matrix extracellular phosphoglycoprotein (MEPE)/ osteoblast/osteocyte factor 45 (OF45) by fibroblast growth factor 2 in cultures of rat bone marrow-derived osteoblastic cells.
    Endocrine. 2004 Jun;24(1):15-24. PMID:15249699
    doi: 10.1385/ENDO:24:1:015
  • 9. Bandow K, Ohnishi T, Tamura M, Semba I, Daikuhara Y.
    Hepatocyte growth factor/scatter factor stimulates migration of muscle precursors in developing mouse tongue.
    J Cell Physiol. 2004 Nov;201(2):236-43. PMID:15334658
    doi:10.1002/jcp.20056
  • 8. Tsuji K, Uno K, Zhang GX, Tamura M.
    Periodontal ligament cells under intermittent tensile stress regulate mRNA expression of osteoprotegerin and tissue inhibitor of matrix metalloprotease-1 and -2.
    J Bone Miner Metab. 2004;22(2):94-103. PMID:14999519
    doi:10.1007/s00774-003-0456-0
  • 7. Sato Y, Kikuchi M, Ohata N, Tamura M, Kuboki Y.
    Enhanced cementum formation in experimentally-induced cementum defects of the root surface with the application of recombinant basic fibroblast growth factor in collagen gel in vivo.
    J Periodontol. 2004 Feb;75(2):243-8. PMID:15068112
    doi:10.1902/jop.2004.75.2.243
  • 6. Wada K, Mizuno M, Komori T, Tamura M.
    Extracellular inorganic phosphate regulates Glvr-2 phosphate transporter/retrovirus receptor mRNA expression in rat bone barrow stromal cells.
    J Cell Physiol. 2004 Jan;198(1):40-7. PMID:14584042
    doi:10.1002/jcp.10383
  • (2003)
    5. Nakamura T, Yamamoto M, Tamura M, Izumi Y.
    Effects of growth/differentiation factor-5 on human periodontal ligament cells.
    J Periodontal Res. 2003 Dec;38(6):597-605. PMID:14632923
    doi:10.1034/j.1600-0765.2003.00695.x
  • 4. Tamura M, Nashimoto C, Miyake N, Daikuhara Y, Ochi K, Nashimoto M.
    Intracellular mRNA cleavage by 3´ tRNase under the direction of 2´-O-methyl RNA heptamers.
    Nucleic Acids Res. 2003 Aug 1;31(15):4354-60. PMID:12888494
    doi:10.1093/nar/gkg641
  • (2002)
    3. Kakimoto K, Machigashira M, Ohnishi T, Kajihara T, Semba I, Setoguchi T, Tamura M, Izumi Y, Daikuhara Y.
    Hepatocyte growth factor (HGF) levels in gingival crevicular fluid and distribution of HGF-activator in gingival tissue from adult periodontics.
    Arch Oral Biol. 2002 Sep;47(9):655-63. PMID:12243969
    doi:10.1016/S0003-9969(02)00050-X
  • 2. Sato Y, Takita H, Ohata N, Tamura M, Kuboki Y.
    Pleiotrophin regulates bone morphogenetic protein (BMP)-induced ectopic osteogenesis.
    J Biochem. 2002 Jun;131(6):877-86. PMID:12038985
  • (2001)
    1. Nashimoto M, Nashimoto C, Tamura M, Kaspar RL, Ochi K.
    The inhibitory effect of the autoantigen La on in vitro 3′ processing of mammalian precursor tRNAs.
    J Mol Biol. 2001 Oct 5;312(5):975-84. PMID:11580243
    doi:10.1006/jmbi.2001.5026
  • Review
    Fujisawa R, Tamura M.
    Acidic bone matrix proteins and their roles in calcification.
    Front Biosci. 2012 Jan 1;17:1891-903. PMID: 22201843
    doi:10.2741/4026
  • Tamura M, Nemoto E, Sato MM, Nakashima A, Shimauchi H.
    Role of the Wnt signaling pathway in bone and tooth.
    Front Biosci. 2010, Jun 1; E2: 1405-1413. PMID:20515813
    doi:org/10.2741/201
  • Nakashima A, Nashimoto M, Tamura M.
    TRUE gene silencing -Gene-silencing by the tRNA maturase tRNase ZL under the direction of small guide RNA-
    J Oral Biosci 49: 54-64, 2007.
  • Tamura M, Zhang XA, Nakashima A.
    Angiogenesis and bone formation.
    Connective Tissue 36: 139-147, 2004.