（概要）2021（令和３年）年度「科学的リテラシーのトレーニング：上級編（第３期）」として、Journal Clubを行なっています。徹底的理解と批判的読解力、プレゼン力、質疑応答力、自らの研究への応用力を鍛えています。

2021年度は22報の論文について議論しました。

20220315　
発表者：劉　雲青（Liu Yunqing）
Luther, J. et al.
Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand.
Sci Transl Med 10 (2018).
https://doi.org:10.1126/scitranslmed.aau7137

20220301
発表者：佐藤　孝紀
Matsushita, Y. et al. A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration.
Nat Commun 11, 332 (2020).
https://doi.org:10.1038/s41467-019-14029-w

20220216　
発表者：渡辺　陽久
Xia, W. et al.
Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors.
Nat Commun 12, 6043 (2021).
https://doi.org:10.1038/s41467-021-26302-y

20220201　
発表者：星（沼端）　麻里絵
Villa, A. et al.
Sex-Specific Features of Microglia from Adult Mice.
Cell Rep 23, 3501-3511 (2018).
https://doi.org:10.1016/j.celrep.2018.05.048

20220118
発表者：中西（木村）　徳子
Men, Y. et al. Gli1+ Periodontium Stem Cells Are Regulated by Osteocytes and Occlusal Force.
Dev Cell 54, 639-654 e636 (2020).
https://doi.org:10.1016/j.devcel.2020.06.006

20220111
発表者：庵　敬
Raoof, R. et al.
Dorsal Root Ganglia Macrophages Maintain Osteoarthritis Pain.
J Neurosci 41, 8249-8261 (2021).
https://doi.org:10.1523/JNEUROSCI.1787-20.2021

20211214　
発表者：劉　雲青（Liu Yunqing）
Liu, X. et al.
Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis.
Nat Commun 12, 1832 (2021).
https://doi.org:10.1038/s41467-021-22131-1

20211207　
発表者：佐藤　孝紀
Saito, H. et al.
TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone.
Nat Commun 10, 1354 (2019).
https://doi.org:10.1038/s41467-019-08778-x

20211130
発表者：李　智媛
Mun, S. H. et al.
Sexual Dimorphism in Differentiating Osteoclast Precursors Demonstrates Enhanced Inflammatory Pathway Activation in Female Cells.
J Bone Miner Res 36, 1104-1116 (2021).
https://doi.org:10.1002/jbmr.4270

20211116
発表者：星（沼端）　麻里絵
Fu, R. et al.
Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis.
Nat Commun 11, 460 (2020).
https://doi.org:10.1038/s41467-019-14076-3

20211019
発表者：佐藤　孝紀
Morimoto, A. et al.
SLPI is a critical mediator that controls PTH-induced bone formation.
Nat Commun 12, 2136 (2021).
https://doi.org:10.1038/s41467-021-22402-x

20211012
発表者：李　智媛
Surface, L. E. et al.
ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.
Sci Transl Med 12 (2020).
https://doi.org:10.1126/scitranslmed.aav9166

20211005
発表者：星（沼端）　麻里絵
Caire, R. et al.
Parathyroid Hormone Remodels Bone Transitional Vessels and the Leptin Receptor-Positive Pericyte Network in Mice.
J Bone Miner Res 34, 1487-1501 (2019).
https://doi.org:10.1002/jbmr.3728

20210928
発表者：中西（木村）　徳子
Tatsumi, S. et al.
Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.
Cell Metab 5, 464-475 (2007).
https://doi.org:10.1016/j.cmet.2007.05.001

20210727
発表者：佐藤　孝紀
Li, J. et al.
TGFbeta-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis.
Nat Commun 10, 2795 (2019).
https://doi.org:10.1038/s41467-019-10677-0

20210720
発表者：庵　敬
Koyanagi, S. et al.
Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia.
Nat Commun 7, 13102 (2016).
https://doi.org:10.1038/ncomms13102

20210713
発表者：劉　雲青（Liu Yunqing）
Yu, S. et al.
BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation.
Cell Death Dis 12, 197 (2021).
https://doi.org:10.1038/s41419-021-03480-7

20210629
発表者：李　智媛
Willis, E. F. et al.
Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner.
Cell 180, 833-846 e816 (2020).
https://doi.org:10.1016/j.cell.2020.02.013

20210622
発表者：佐藤　孝紀
Lotinun, S. et al.
Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression.
J Clin Invest 129, 3058-3071 (2019).
https://doi.org:10.1172/JCI122936

20210608
発表者：星（沼端）　麻里絵
Langen, U. H. et al.
Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.
Nat Cell Biol 19, 189-201 (2017).
https://doi.org:10.1038/ncb3476

20210427
発表者：劉　雲青（Liu Yunqing）
Fan, Y. et al.
Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate.
Cell Metab 25, 661-672 (2017).
https://doi.org:10.1016/j.cmet.2017.01.001

20210413
発表者：庵　敬
Sominsky, L. et al.
Microglial ablation in rats disrupts the circadian system.
FASEB J 35, e21195 (2021).
https://doi.org:10.1096/fj.202001555RR