（概要）
2022（令和４年）年度「科学的リテラシーのトレーニング：上級編（第4期）」として、Journal Clubを行なっています。徹底的理解と批判的読解力、プレゼン力、質疑応答力、自らの研究への応用力を鍛えています。

2022年度は30報の論文について議論しました。

20230314　発表者：庵　敬
Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity.
Kohro, Y. et al. Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity.
Nat Neurosci 23, 1376-1387 (2020).
https://doi.org:10.1038/s41593-020-00713-4

20230307　
発表者：中西（木村）　徳子
Dong, B. et al.
Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis.
Nat Commun 13, 7194 (2022).
https://doi.org:10.1038/s41467-022-34869-3

20230228
発表者：西浦　まい
Whitlock, J. M. et al.
Cell surface-bound La protein regulates the cell fusion stage of osteoclastogenesis.
Nat Commun 14, 616 (2023).
https://doi.org:10.1038/s41467-023-36168-x
20230221

 

20230221
発表者：高田健太郎 （理学院自然史科学専攻　小林快次教授研究室）
Mallouchou, M. et al.
Mapping Cheshire Cats' Leg: A histological approach of cortical bone tissue through modern GIS technology.
Anat Sci Int 95, 104-125 (2020).
https://doi.org:10.1007/s12565-019-00503-4

20230214　
発表者：渡辺　陽久
Parisien, M. et al.
Acute inflammatory response via neutrophil activation protects against the development of chronic pain.
Sci Transl Med 14, eabj9954 (2022).
https://doi.org:10.1126/scitranslmed.abj9954

20230207　
発表者：星（沼端）　麻里絵
Shi, Y. et al.
Gli1(+) progenitors mediate bone anabolic function of teriparatide via Hh and Igf signaling.
Cell Rep 36, 109542 (2021).
https://doi.org:10.1016/j.celrep.2021.109542

20230131
発表者：庵　敬
Li, J. et al.
Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn.
J Neuroinflammation 19, 123 (2022).
https://doi.org:10.1186/s12974-022-02489-9

20230124　
発表者：中西（木村）　徳子
Riquelme, M. A., Gu, S., Hua, R. & Jiang, J. X. Mechanotransduction via the coordinated actions of integrins, PI3K signaling and Connexin hemichannels.
Bone Res 9, 8 (2021).
https://doi.org:10.1038/s41413-020-00126-w

20221213
発表者：高田健太郎 （理学院自然史科学専攻　小林快次教授研究室）
Funston, G. F. et al.
The origin of placental mammal life histories.
Nature 610, 107-111 (2022).
https://doi.org:10.1038/s41586-022-05150-w

20230117
発表者：西浦　まい
Andrew, T. W. et al.
Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration.
Nat Commun 13, 6491 (2022).
https://doi.org:10.1038/s41467-022-34063-5

20221122　
発表者：渡辺　陽久
Yan, Y. et al.
X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.
Cell 185, 3913-3930 e3919 (2022).
https://doi.org:10.1016/j.cell.2022.09.002

20221108　
発表者：星（沼端）　麻里絵
Romeo, S. G. et al.
Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation.
Nat Cell Biol 21, 430-441 (2019).
https://doi.org:10.1038/s41556-019-0304-7

20221101　
発表者：庵　敬
Zhang, L. et al.
Chronic pain induces nociceptive neurogenesis in dorsal root ganglia from Sox2-positive satellite cells.
Glia 67, 1062-1075 (2019).
https://doi.org:10.1002/glia.23588

20221025　
発表者：中西（木村）　徳子
Zhao, D. et al.
Osteocytes regulate bone anabolic response to mechanical loading in male mice via activation of integrin alpha5.
Bone Res 10, 49 (2022).
https://doi.org:10.1038/s41413-022-00222-z

20221004
発表者：渡辺　陽久
Dejanovic, B. et al.
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models.
Nat Aging 2, 837-850 (2022).
https://doi.org:10.1038/s43587-022-00281-1

20220927
発表者：星（沼端）　麻里絵
Wei, H. et al.
Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target.
Cell Rep 33, 108252 (2020).
https://doi.org:10.1016/j.celrep.2020.108252

20220920
発表者：庵　敬
Konishi, H. et al.
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.
EMBO J 39, e104464 (2020).
https://doi.org:10.15252/embj.2020104464

20220719
発表者：中西（木村）　徳子
Estell, E. G. et al.
Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo.
Elife 9 (2020).
https://doi.org:10.7554/eLife.58172

20220715　
発表者：佐藤　孝紀
Chen, H. et al.
Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis.
Nat Commun 10, 181 (2019).
https://doi.org:10.1038/s41467-018-08097-7

20220628
発表者：西浦　まい
Xu, Z. X. et al.
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.
Nat Commun 11, 1797 (2020).
https://doi.org:10.1038/s41467-020-15530-3

20220621
発表者：渡辺　陽久
Hoshi, Y., Shibasaki, K., Gailly, P., Ikegaya, Y. & Koyama, R. Thermosensitive receptors in neural stem cells link stress-induced hyperthermia to impaired neurogenesis via microglial engulfment.
Sci Adv 7, eabj8080 (2021).
https://doi.org:10.1126/sciadv.abj8080

20220614　
発表者：星（沼端）　麻里絵
Sivaraj, K. K. et al.
Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing.
Nat Commun 13, 571 (2022).
https://doi.org:10.1038/s41467-022-28142-w

20220607　
発表者：中西（木村）　徳子
Zhao, D. et al.
Connexin hemichannels with prostaglandin release in anabolic function of bone to mechanical loading. Elife 11 (2022).
https://doi.org:10.7554/eLife.74365

20220531
発表者：庵　敬
Zhang, J. et al. The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice.
J Inflamm Res 14, 6633-6656 (2021). https://doi.org:10.2147/JIR.S330894

20220524
発表者：佐藤　孝紀
Kohno, K. et al.
A spinal microglia population involved in remitting and relapsing neuropathic pain.
Science 376, 86-90 (2022).
https://doi.org:10.1126/science.abf6805

20220517　
発表者：西浦　まい
Uenaka, M. et al.
Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo.
Nat Commun 13, 1066 (2022).
https://doi.org:10.1038/s41467-022-28673-2

20220510
発表者：渡辺　陽久
Hu, Y. et al.
Replicative senescence dictates the emergence of disease-associated microglia and contributes to Abeta pathology.
Cell Rep 35, 109228 (2021).
https://doi.org:10.1016/j.celrep.2021.109228

20220426　
星（沼端）　麻里絵
Sivaraj, K. K. et al.
Regional specialization and fate specification of bone stromal cells in skeletal development.
Cell Rep 36, 109352 (2021).
https://doi.org:10.1016/j.celrep.2021.109352

20220429
発表者：中西（木村）　徳子
Storlino, G. et al.
Irisin Prevents Disuse-Induced Osteocyte Apoptosis.
J Bone Miner Res 35, 766-775 (2020).
https://doi.org:10.1002/jbmr.3944

20220412　発表者：庵　敬
van der Vlist, M. et al.
Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain.
Neuron 110, 613-626 e619 (2022).
https://doi.org:10.1016/j.neuron.2021.11.020