Research Subjects

○Lamellar structure of bone and cellular cementum

○Origin of cementoblasts

○Atrophy and regeneration of salivary glands

○Effects of liquid diet on salivary glands

○Neurophysiological study for the control mechanism of feeding behavior

○Study for the central mechanism of nausea and vomiting

○Electrophysiological study for the brain functions

○Brain mechanisms of taste sensation

○Study for taste palatability and aversion

○Central nervous system of anorexia nervosa

○Mechanical analysis on removable dentures and dental implants

○Examination of the relationship between occlusion and the gene ral health

of the body

○Development of biomaterials (including dental implant) and investigation

of tissue reaction

○Application of carbon nanomaterials for biomaterials

○Clinical study on the prognosis and effects of prosthodontic treatment

〇Study on sleep bruxism and awake bruxism

〇Study on harmony and disharmony of functional occlusal system

〇Clinical research on sleep apnea syndrome

〇Study on application of additive manufacturing (3D printing) in medical

fields.

〇Development of Dental CAD/CAM System

〇Clinical research in Maxillofacial Prosthetics

○Research for matrix turnover mechanisms after mechanical stress

○Research for mastication and articulation in relation to malocclusions

○Genetic and epidemiological studies on malocclusion

○Study on orthodontic materials and engineering

○Craniofacial growth and developmental study

○Diagnosis and treatment plan for patients with craniofacial deformity

○Diagnosis and treatment plan for cleft lip and palate patients

○Diagnosis and treatment plan for the patients with congenital anomaly.

○Study on measurement of cranio-maxillo-facial morphology by 3D CG model

○Clinical study on central regulatory mechanism of feeding behavior

○Basic and clinical research on physiological and abnormal root resorption of deciduous tooth

○Analysis of adhesive structure of adhesive materials to tooth

○Analysis of effects to central nervous system by change of occlu sion or stress

○Cardiovascular and neuroendocrine responses of pediatric patients during stress induced by dental treatment

○Morphological and functional study of malocculusion in primary dentition

○Clinical study of heart rate variability for disabled patients under dental treatments

○Cell biology on the regulatory function of osteotropic factors

○Cell biological and genetic assessment for bone development and regeneration

○Morphological and molecular study on the cell structure and function of bone cells

○Molecular mechanisms of bone formation and resorption

○Biochemistry and molecular biology of oral tissue

○Regulation of gene expression

○Development of novel biomaterials

○Nano-interfacial control for functional reconstruction of biological hard tissues

○Translational research on dental materials and devices

○Application of nano-technology in the dental fields

○Establishment of material evaluation system using in vitro osseointegration model

○Basic research for the construction of in vitro oral tissues model

○Examination of the factors affecting functional recovery and prognosis in the patients with partial edentulism

○Oral care for perioperative patient

○Molecular biology in oral microorganisms

○Epidemiological Study for dental caries, periodontal disease and dry mouth

○Operative Dentistry

○Cariology

○Biocompatibility

○Nanotechnology for dentistry

○Etiology and development of periodontal disease

○New techniques of periodontal examination, diagnosis, prevention and treatment

○Development of periodontal regenerative therapy

○Improvement of endodontic therapy

○Periodontal destruction in endodontic, peridontic, and traumatic lesions

○Development of treatment of vertical root fracture

○Impact of oral health care on autonomy in older adults

○Influence of oral health status on quality of life in older adults

○Relationship between nutrition and oral health in older adults

○Age-associated changes in masticatory system

○Prevention and treatment of oral disease in older adults

○Treatment and pathophysiology of oral psychosomatic disorders

○Abnormalities of tumor vascular endothelial cells and development of novel

therapy

○Blood vessels and inflammation

○Endotheliopathy in COVID-19

○Blood vessel regeneration

○Utilization of microbial sequences for novel gene-tuning system

○Development and application of HPV detection systems

○Recognition and removal of oral microbes by innate immunity

○Structures and biological activities of oral microbial molecular patterns

○Oral tolerance against oral bacteria

○Clinical Application of Oncolytic virus

○Nobel pharmacological effects of anti-osteoporotic drugs

○Nobel pharmacological effects of anti-virus drugs

○Investigation of biological markers for skeletal diseases

○Development of quantitative imaging system for pharmacology

○Interaction between osteoblast and osteoclast

○Effect of mechanical stress on bone-cells and periodontal cells

○Molecular imaging of oral diseases

○Positron Emission Tomography (PET) for evaluation of chemoradiotherapy

in oral cancer

○Hypoxia imaging, FMISO-PET to evaluate oral cancer

○PET for evaluation of osteomyelitis of the jaw

○Inflammatory cytokines and stress hormones in saliva and oral medicine

diseases

○Pathogenic role of autoantibodies of mucous membrane pemphigoid

○Clinical study of Oral Candidiasis and innate immunity

○Angiogenesis from periodontal ligament fibroblasts

○Muscle pathology on masticatory muscles

○Prevention of MRONJ using platelet rich fibrin

〇Molecular biologic research in various diseases in oral medicine.

〇Molecular biology on effects of Japanese traditional medicine (Kanpo)

○Prevention of oral cancer carcinogenesis and progression based on salivary

oral bacterial microbiome and inflammatory cytokines

○Study of zinc replacement therapy for taste disorders　-Relationship

between serum zinc level and zinc enzyme expression in saliva –

○Basic and clinical studies of oral cancer

○Study on comprehensive treatment of cleft lip and palate preventing maxillary growth impediment

○Study on dredging method as a conservative treatment for ameloblastoma

○Study on functional and morphological improvement of skeletal malocclusion

○Study on eating and swallowing function in the elderly and postoperative

patients with oral cancer

○Study on alveolar augmentation for tooth transplantation and dental implant

○Study for radiological imaging diagnosis on oral and maxillofacial lesions

○Clinical study of radiotherapy for oral cancers

○Molecular biology of oral cancers

○Study for radiation protection

○Experimental and clinical studies on stress reactions

○Studies on mechanism of pharmacological actions of anesthetics

○Studies on monitors used in general management during dental treatment

○Study on carediovascular and endocrine changes in dental surgery

○Study on effects of tringeminal stimulation on autonomic function

○Study on anesthetic management of dental treatment in persons with disabilities

○Physico-chemical and ultra-morphological study on adhesion between tooth substrates and dental restorative materials

○Research on General Dentistry

○Studies on under-graduate and post-graduate clinical training

○Globalization in dentistry

○Clinical oral physiology

○Temporomandibular disorders

○Sensory-motor interaction in orofacial region

○New treatment methods for Sleep Apnea

○Clinical research on etiology, diagnosis and management of temporomandibular disorders

○Research on mascular activity and blood flow state of masticatory muscles

○Clinical research on Orofacial Pain

○Dental implants for dento-maxillary defect

○Bone augmentation for dental implants

○Selection and installation condition of implant bodies

○Study on osteoblast differentiation of somatic stem cells

○Study on comprehensive treatment of cleft lip and palate against maxillary growth impediment

○Molecular genetic study on cleft lip and palate

○Study on velopharyngeal function

〇Study on application to the palatal plate of the adhesive gels

〇Study on mouth guards

○The role and application of nitric monoxide to periodontal tissues

○Pathological analysis and control of periodontal disease as a vascular disease