Research Subjects

○Lamellar structure of bone and cellular cementum

○Origin of cementoblasts

○Atrophy and regeneration of salivary glands

○Effects of liquid diet on salivary glands

○Neurophysiological study for the control mechanism of feeding behavior

○Study for the central mechanism of nausea and vomiting

○Electrophysiological study for the brain functions

○Brain mechanisms of taste sensation

○Study for taste palatability and aversion

○Central nervous system of anorexia nervosa

○Mechanical analysis on removable dentures and dental implants

○Examination of the relationship between occlusion and the gene ral health

of the body

○Development of biomaterials (including dental implant) and investigation

of tissue reaction

○Application of carbon nanomaterials for biomaterials

○Clinical study on the prognosis and effects of prosthodontic treatment

○Research on genesis of bruxism and development of effective treatment methods

○Clinical research on sleep apnea-hypopnea syndrome

○Research on genesis of persistent uncomfortable occlusion by using brain function analysis

○3D Printing Technology Applying for Medicine

○Development of Dental CAD/CAM System

○Clinical Researches in Maxillofacial Prosthetics

○Researches on Dental Materials

○Research for matrix turnover mechanisms after mechanical stress

○Research for mastication and articulation in relation to malocclusions

○Research for genetic cause of malocclusions

○Study on orthodontic materials and engineering

○Craniofacial growth and developmental study

○Diagnosis and treatment plan for patients with craniofacial deformity

○Diagnosis and treatment plan for cleft lip and palate patients

○Diagnosis and treatment plan for the patients with congenital anomaly.

○Study on measurement of cranio-maxillo-facial morphology by 3D CG model

○Clinical study on central regulatory mechanism of feeding behavior

○Basic and clinical research on physiological and abnormal root resorption of deciduous tooth

○Analysis of adhesive structure of adhesive materials to tooth

○Analysis of effects to central nervous system by change of occlu sion or stress

○Cardiovascular and neuroendocrine responses of pediatric patients during stress induced by dental treatment

○Morphological and functional study of malocculusion in primary dentition

○Clinical study of heart rate variability for disabled patients under dental treatments

○Cell biology on the regulatory function of osteotropic factors

○Cell biological and genetic assessment for bone development and regeneration

○Morphological and molecular study on the cell structure and function of bone cells

○Molecular mechanisms of bone formation and resorption

○Biochemistry and molecular biology of oral tissue

○Regulation of gene expression

○Development of novel biomaterials

○Nano-interfacial control for functional reconstruction of biological hard tissues

○Translational research on dental materials and devices

○Application of nano-technology in the dental fields

○Establishment of material evaluation system using in vitro osseointegration model

○Basic research for the construction of in vitro oral tissues model

○Examination of the factors affecting functional recovery and prognosis in the patients with partial edentulism

○Oral care for perioperative patient

○Molecular biology in oral microorganisms

○Epidemiological Study for dental caries, periodontal disease and dry mouth

○Operative Dentistry

○Cariology

○Biocompatibility

○Nanotechnology for dentistry

○Etiology and development of periodontal disease

○New techniques of periodontal examination, diagnosis, prevention and treatment

○Development of periodontal regenerative therapy

○Improvement of endodontic therapy

○Periodontal destruction in endodontic, peridontic, and traumatic lesions

○Development of treatment of vertical root fracture

○Impact of oral health care on autonomy in older adults

○Influence of oral health status on quality of life in older adults

○Relationship between nutrition and oral health in older adults

○Age-associated changes in masticatory system

○Prevention and treatment of oral disease in older adults

○Treatment and pathophysiology of oral psychosomatic disorders

1) Abnormalities of tumor vascular endothelial cells and development of novel therapy

2) Blood vessels and inflammation

3) Endotheliopathy in COVID-19

4) Blood vessel regeneration

5) Association between RNA and cell oncogenesis

6) Development and application of oncolytic virus

○Utilization of microbial sequences for novel gene-tuning system

○Development and application of HPV detection systems

○Recognition and removal of oral microbes by innate immunity

○Structures and biological activities of oral microbial molecular patterns

○Oral tolerance against oral bacteria

○Nobel pharmacological effects of anti-osteoporotic drugs

○Nobel pharmacological effects of anti-virus drugs

○Investigation of biological markers for skeletal diseases

○Development of quantitative imaging system for pharmacology

○Interaction between osteoblast and osteoclast

○Effect of mechanical stress on bone-cells and periodontal cells

○Molecular imaging of oral diseases

○Positron Emission Tomography (PET) for evaluation of chemoradiotherapy in oral cancer

○Hypoxia imaging, FMISO-PET to evaluate oral cancer

○PET for evaluation of osteomyelitis of the jaw

○Inflammatory cytokines in saliva and oral medicine diseases

○Pathogenic role of autoantibodies of mucous membrane pemphigoid

○Clinical study of Oral Candidiasis and innate immunity

○Angiogenesis from periodontal ligament fibroblasts

○Muscle pathology on masticatory muscles

○Prevention of MRONJ using platelet rich fibrin

〇Molecular biologic research in various diseases in oral medicine.

〇Molecular biology on effects of Japanese traditional medicine (Kanpo)

○Basic and clinical studies of oral cancer

○Study on comprehensive treatment of cleft lip and palate preventing maxillary growth impediment

○Study on dredging method as a conservative treatment for ameloblastoma

○Study on functional and morphological improvement of skeletal malocclusion

○Study on eating and swallowing function in the elderly and postoperative

patients with oral cancer

○Study on alveolar augmentation for tooth transplantation and dental implant

○Study for radiological imaging diagnosis on oral and maxillofacial lesions

○Clinical study of radiotherapy for oral cancers

○Molecular biology of oral cancers

○Study for radiation protection

○Experimental and clinical studies on stress reactions

○Studies on mechanism of pharmacological actions of anesthetics

○Studies on monitors used in general management during dental treatment

○Study on carediovascular and endocrine changes in dental surgery

○Study on effects of tringeminal stimulation on autonomic function

○Study on anesthetic management of dental treatment in persons with disabilities

○Physico-chemical and ultra-morphological study on adhesion between tooth substrates and dental restorative materials

○Research on General Dentistry

○Studies on under-graduate and post-graduate clinical training

○Globalization in dentistry

○Clinical oral physiology

○Temporomandibular disorders

○Sensory-motor interaction in orofacial region

○Clinical research on etiology, diagnosis and management of temporomandibular disorders

○Research on mascular activity and blood flow state of masticatory muscles

○Clinical research on Orofacial Pain

○Dental implants for dento-maxillary defect

○Bone augmentation for dental implants

○Selection and installation condition of implant bodies

○Study on comprehensive treatment of cleft lip and palate against maxillary growth impediment

○Molecular genetic study on cleft lip and palate

○Study on velopharyngeal function

〇Study on application to the palatal plate of the adhesive gels

〇Study on mouth guards

○The role and application of nitric monoxide to periodontal tissues

○Pathological analysis and control of periodontal disease as a vascular disease