〒060-8586
札幌市北区北13条西7丁目
北海道大学大学院歯学研究科
口腔健康科学講座
硬組織発生生物学教室
TEL:011-706-4226（ダイヤルイン）


李　敏啓 (LI MINQI)　


略歴

平成１６年　３月３１日　新潟大学医歯学総合研究科修了
平成１６年　９月　１日　独立法人日本学術振興会　外国人特別研究員
平成１８年　９月　１日　新潟大学超域研究機構　研究支援者
平成２０年　１月　１日　新潟大学超域研究機構　助教
平成２１年　８月　１日　北海道大学大学院歯学研究科　助教
平成２４年　２月　１日　山東大学口腔医学院　教授

 

主な研究テーマ

≪骨代謝における形態学的・微細構造学的研究≫
骨基質石灰化のメカニズムを解明するために、モデル動物を用いて微細構造学的に解析を行っています。また、骨細胞の微細構造や機能について、 近年報告されたリン代謝調節因子との関連性に注目してアプローチを進めています。


受賞歴

The 2nd Joint Meeting of ECTS-IBMS Travel Award, Geneva, 2005
Immunolocalization of cathepsin K and MMP-9 secreted by osteoclasts in the osteolytic metastasis.

第28回日本骨形態計測学会　若手研究者賞、東京、2008
アスコルビン酸合成能欠如モデルにおける骨組織異常の形態学的検討.

 

研究業績

　　英文論文

  1. Tabata C., Hongo H., Sasaki M., Hasegawa T., Freitas PHL., Yamada T., Yamamoto T., Suzuki R., Oda K., Li M., Yamamoto T., Kudo A., Iida J., Amizuka N.: Altered distribution of extracellular matrix proteins in the periodontal ligament of periostin-deficient mice. Hokkaido Journal of Dental Science. in submission.
  2. Sasaki M., Yamada T., Hasegawa T., Hongo H., Freitas PHL., Suzuki R., Yamamoto T., Tabata C., Toyosawa S., Yamamoto T., Oda K., Li M., Inoue N., Amizuka N.: Altered distribution of bone matrix proteins and defective bone mineralization in klotho-deficient mice. Hokkaido Journal of Dental Science. in submission.
  3. Kojima T, Hasegawa T, Yamada T, Sasaki M, Li M, Freitas PHL, Yamamoto T, Saito N, Kobayashi T, Oda K, Kosaki N, Maeda K, Saito C, Takaishi H, Amizauka N.: Histochemical examination for vascular invasion at the erosion zone of epiphyseal cartilage in MMP-9 deficient mice. in preparation.
  4. Li M., Hasegawa T., Hongo H., Tatsumi S., Liu Z., Guo Y., Sasaki M., Tabata C., Yamamoto T., Ikeda K., Amizuka N.: Histological examination on osteoblastic activities in the alveolar bone of transgenic mice with induced ablation of osteocytes. Histology and Histopathol. in submission.
  5. Nagata M., Hoshina H., Li M., Arasawa M., Uematsu K., Ogawa S., Yamada K., Kawase T., Suzuki K., Ogose A., Fuse I., Okuda K., Uoshima K., Nakata K., Yoshie H., Takagi R.: A clinical study of the alveolar bone tissue engineering with cultured autogenous periosteal cells: coordinated activation of bone formation and resorption. Bone. in submission
  6. Sasaki M., Hongo H., Hasegawa T., Freitas PHL., Suzuki R., Oda K., Toraya H., Yamamto T., Li M., Inoue N., Amizuka N.: Altered immunolocalization of DMP-1, osteocalcin and MGP in osteocytic lacunar canalicular system of klotho-deficient epiphysis. J Bone Miner Metab. in revision
  7. Guo Y., Li M., Liu Z., Yamada T., Sasaki M., Hasegawa T., Hongo H., Tabata C., Suzuki R., Oda K., Yamamoto T., Kawanami M., Amizuka N.: Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats. J Electron Microsc. 61(5):309-320, 2012.
  8. Yamamoto T., Hasegawa T., Sasaki M., Hongo H., Guo Y., Tabata C., Liu Z., Li M., Amizuka N.: Structure and formation of the twisted plywood pattern of collagen fibrils in rat lamellar bone.J Electron Microsc. in press
  9. Li M., Hasegawa T., Hongo H., Tatsumi S., Liu Z., Guo Y., Sasaki M., Tabata C., Yamamoto T., Ikeda K., Amizuka N.: Histological examination on osteoblastic activities in the alveolar bone of transgenic mice with induced ablation of osteocytes. Histology and Histopathol. in submission
  10. Nagata M., Hoshina H., Li M., Arasawa M., Uematsu K., Ogawa S., Yamada K., Kawase T., Suzuki K., Ogose A., Fuse I., Okuda K., Uoshima K., Nakata K., Yoshie H., Takagi R.: A clinical study of the alveolar bone tissue engineering with cultured autogenous periosteal cells: coordinated activation of bone formation and resorption. Bone. in submission
  11. Sasaki M., Hongo H., Hasegawa T., Suzuki R., Liu Z., Freitas PHL., Oda K., Yamamoto T., Li M., Totsuka Y., Amizuka N.: Morphological Aspects on Osteocytic Function on Bone Mineralization. Oral Science International. in press
  12. Hongo H., Hasegawa T., Sasaki M., Suzuki R., Yamada T., Shimoji S., Yamamoto T.,  Amizuka N.: Bone-Orchestrating Cells, Osteocytes. Hokkaido Journal of Dental Science.  in press
  13. Amizuka N., Sasaki M., Hongo H., Hasegawa T., Yamada T., Yamamoto T., Freitas PHL., Li M.: The biological function of parathyroid hormone and parathyroid hormone-related peptide in osteoblastic cells.
  14. Amizuka N., Hongo H., Sasaki M., Hasegawa T., Suzuki R., Tabata C., Ubaidus S., Masuki H., Guo Y., Freitas PHL., Oda K., Li M.: The distribution of osteocytic lacunar-canalicular system, and immunolocalization of FGF23 and sclerostin in osteocytes. J Oral Biosci. in press
  15. Hasegawa T, Li M, Hara K, Sasaki M, Tabata C, Freitas PHL, Hongo H, Suzuki R, Kobayashi M, Inoue K, Yamamoto T, Oda K, Akiyama Y, Amizuka N: Morphological assessment of bone mineralization in tibial metaphyses of ascorbic acid-deficient ODS rats.Biomedical Res. 32(4):259-269, 2011
  16. Freitas PHL, Hasegawa T, Takeda S, Sasaki M, Tabata C, Oda K, Li M, Saito H, Amizuka N: Eldecalcitol, a second-generation vitamin D analog, drives bone minimodeling and reduces osteoclastic number in the trabecular bone of ovariectomized rats.Bone.49(3):335-342,2011
  17. Amizuka N, Hasegawa T, Oda K, Freitas PHL, Hoshi K, Li M, Ozawa H : Histological aspects of epiphyseal cartilage calcification and endochondral ossification. in press.
  18. Haga M, Nozawa-Inoue K, Li M, Oda K, Yoshie S, Amizuka N, Maeda T. Amorphologicalanalysis on the osteocytic lacunar canalicular system in bone surrounding dental implants. The Anatomical Record. 294(6):1074-1082, 2011
  19. Masuki H, Li M, Guo Y, Hasegawa T, Liu Z, Suzuki R, Oda K, Yamamoto T, Kawanami M and Amizuka N: Immunolocalization of DMP-1 and sclerostin in the epiphyseal trabecule and diaphyseal cortical bone of osteoprotegerin deficient mice. Biomedical Res. 31(5):307-318, 2010
  20. Watanabe Y, Takeuchi K, Higa Onaga S, Sato M, Tsujita M, Abe M, Natsume R, Li M, Furuichi T, Saeki M, Izumikawa T, Hasegawa A, Yokoyama M, Ikegawa S, Sakimura K, Amizuka N, Kitagawa H, Igarashi M : Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Biochem J. 432(1):47-55, 2010 Oct 25
  21. Li　M, Hasegawa T, Masuki H, Liu Z, Guo Y, Suzuki R, Yamamoto T, Freitas PHL and Amizuka N: Ultrastructural Assessment of Mineral Crystallization and Collagen Mineralization in Bone. J. Oral Biosci. 52(2):94-99, 2010
  22. Yamamoto T, Li M, Liu Z, Guo Y, Hasegawa T, Masuki H, Suzuki R, Amizuka N : Histological review of the human cellular cementum with special reference to an alternating lamellar pattern. Odontology. 98(2):102-109, 2010
  23. Tanabe H, Takayama I, Nishiyama T, Shimazaki M, Kii I, Li M, Amizuka N, Katsube K, Kuda A: Periostin associates with Notch1 precusor to maintain Notch 1 exression under a stress condition in mouse cells. PLoSONE . 18;5(8). pii: e12234. 2010 Aug
  24. Narimatsu K, Li M, FreitaS PHL, Sultana S, Ubaidus S, Kojima T, Liu Z, Guo Y, Suzuki R Yamamoto T, Oda K, Amizuka N. Ultrastructural observation on cells with characteristics of histological criteria for preosteoblasts in mouse tibial metaphysis. J Electron Microsc. 59(5):427-436, 2010. Epub 2010 May 25.
  25. Li M, Seki Y, Freitas HLP, Nagata M, Kojima T, Sultana S, Ubaidus S, Maeda T, Shimomura-Kuroki J, Henderson J, Tamura M, Liu Z, Guo Y, Yamamoto T, Oda K, Takagi R, Amizuka N. FGFR3 down-regulates PTH/PTHrP receptor gene expression by mediating JAK/STAT signaling in chondrocytic cell line. J Electron Microsc. 59(3):227-236, 2010.
  26. Kii I, Nishiyama T, Li M, Matsumoto KI, Saito M, Amizuka N, Kudo A.: Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J Biol Chem. 285(3):2028-2039, 2010.
  27. Segawa H, Onitsuka A, Furutani J, Kaneko I, Aranami F, Matsumoto N, Tomoe Y, Kuwahata M, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K.: Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.Am J Physiol Renal Physiol. 297(3):F671-678, 2009.
  28. Ubaidus S Li M, Sultana S, de Freitas PH, Oda K, Maeda T, Takagi R, Amizuka N.: FGF23 is mainly synthesized by osteocytes in the regularly distributed osteocytic lacunar canalicular system established after physiological bone remodeling.J Electron Microsc.58(6):381-392, 2009.
  29. Freitas PHL, Li M, Ninomiya T, Nakamura M, Ubaidus S, Oda K, Udagawa N, Maeda T, Takagi R, Amizuka N: Intermittent PTH administration stimulates pre-osteoblastic proliferation without leading to enhanced bone formation in osteoclast-less c-fos(-/-) mice. J Bone Miner Res. 24(9):1586-1597, 2009.
  30. Amizuka, N., Li, M., Hara, K., Kobayashi, M., de Freitas, PH., Ubaidus, S., Oda, K., Akiyama, Y.: Warfarin administration disrupts the assembly of mineralized nodules in the osteoid. J Electron Microsc (Tokyo). 58(2): 55-65, 2009.
  31. Segawa, H., Onitsuka, A., Kuwahata, M., Hanabusa, E., Furutani, J., Kaneko, I., Tomoe, Y., Aranami, F., Matsumoto, N., Ito, M., Matsumoto, M., Li, M., Amizuka, N., Miyamoto, KI.: Type IIc Sodium-Dependent Phosphate Transporter Regulates Calcium Metabolism. J Am Soc Nephrol. 20(1): 104-113, 2009.
  32. Amizuka, N., Li, M., Kobayashi, M., Hara, K., Akahane, S., Takeuchi, K., Freitas, PH., Ozawa, H., Maeda, T., Akiyama, Y.: Vitamin K2, a gamma-carboxylating factor of gla-proteins, normalizes the bone crystal nucleation impaired by Mg-insufficiency. Histol Histopathol. 23(11): 1353-1366, 2008.
  33. Nakadate, M., Amizuka, N., Li, M., Freitas, PHL., Oda, K., Nomura, S., Uoshima K., Maeda, T.: Histological Evaluation on Bone Regeneration of Dental Implant Placement Sites grafted with a Self-Setting Alpha-TCP Cement. Microscopy Research & Technique. 71(2): 93-104, 2008.
  34. Shimomura-Kuroki, J., Ubaidus, S., Freitas, PHL., Li, M., Ishida, Y., Saito, N., Oda, K., Shimooka, S., Amizuka, N.: Rat wild-type parathyroid hormone receptor (PTH-R) and mutant PTH-R (P132L) show the different intracellular localization in vitro. Biomed Res. 29(2): 61-69, 2008.
  35. Shimazaki, M., Nakamura, K., Kii, I., Kashima, T., Amizuka, N., Li, M., Fukuda, K., Nishiyama, T., Kitajima, S., Saga, Y., Fukayama, M., Sata, M., and Kudo, A.: Periostin is essential for preventing cardiac rupture after acute myocardial infarction. Journal of Experimental Medicine. 205(2): 295-303, 2008.
  36. Li, M., Sasaki, T., Ono, K., Freitas, PHL., Ubaidus Sobhan, Kojima, T., Shimomura, J., Oda, K., Amizuka, N.: Distribution of macrophages, osteoclasts and the B-lymphocyte lineage in osteolytic metastasis of mouse mammary carcinoma: a histochemical study in non-immunocompromised mice. Biomedical Research. 28 (3): 127-137, 2007.
  37. Hirose, S., Li, M., Kojima, T., Freitas, PHL., Sobhan, U., Sakagami, N., Oda, K., Saito, C., Amizuka, N.: A histological assessment on the distribution of the soteocytes lucunar-canalicular system and its relation with bone remodeling. J Bone Miner Metab. 25(6): 374-382, 2007.
  38. Tatsumi, S., Ishii, K., Amizuka, N., Li, M., Kohno, K., Ito, M., Takeshita, S., Ikeda, K.: Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab. 5(6): 464-475, 2007.
  39. Freitas, PHL., Kojima, T., Sobhan, U., Li, M., Shang, G., Takagi, R., Maeda, T., Oda, K., Ozawa, H., Amizuka, N.: Histological assessments on the abnormalities of mouse epiphyseal chondrocytes with short term centrifugal loading. Biomedical Research. 28(4): 191-203, 2007.
  40. Kojima, T., Freitas, PHL., Sobhan, U. Suzuki, A., Li, M., Yoshizawa, M., Oda, K., Maeda, T., Kudo, A., Saito, C., Amizuka, N.: Histochemical examinations on cortical bone regeneration induced by thermoplastic bioresorbable plates. Biomedical Research. 28 (4): 219-229, 2007.
  41. Kosaki, N., Takaishi, H., Kamekura, S., Kimura, T., Okada, Y., Li, M., Amizuka, N., Chung, U., Nakamura, K., Kawaguchi, H., Toyama, Y., Armiento, J.: Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice. Biochemical and Biophysical Research Communications. 354(4): 846-851, 2007.
  42. Li, M., Amizuka, N., Takeuchi, K., Freitas, PHL., Kawano, Y., Hoshino, M., Oda, K., Nozawa-Inoue, K. and Maeda, T.: Histochemical evidence of osteoclastic degradation of extracellular matrix in osteolytic metastasis originating from human lung small carcinoma (SBC-5) cells. Microscopy Research & Technique. 69(2): 73-83, 2006.
  43. Kii, I., Amizuka, N., Li, M., Kitajima, S., Saga, Y., Kudo, A.: Periostin is an extracellular matrix protein required for eruption of incisors in mice. Biochem. Biophys. Res. Commun. 342 (3): 766-772, 2006.
  44. Suzuki, H., Amizuka, N., Oda, K., Li, M., Noda, M., Yoshie, H., Ohshima, H., Maeda, T.: Histological evidence of the altered distribution of osteocytes and bone matrix synthesis in klotho-deficient mice. Arch Histol Cytol. 68(5): 371-381, 2006.
  45. Oshima, S., Onodera, S., Amizuka, N., Li, M., Irie, K., Watanabe, S., Koyama, Y., Nishihira, J., Yasuda, K., Minami, A.: Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss. FEBS Letters. 580: 1251-1256, 2006.
  46. Ono, K., Kamiya, S., Akatsu, T., Nakamura C., Li, M., Amizuka, N., Matsumoto, K., Nakamura, T., Kugai, N., Wada, S.: Involvement of hepatocyte growth factor in the development of bone metastasis of a mouse mammary cancer cell line, BALB/c-MC. Bone. 39(1): 27-34, 2006.
  47. Onodera, S., Sasaki, S., Ohshima, S., Amizuka, N., Li, M., Udagawa, N., Irie, K., Nishihira, J., Koyama, Y., Shiraishi, A., Tohyama, H., Yasuda, K.: Transgenic mice overexpressing macrophage migration inhibitory factor (MIF) exhibit high-turnover osteoorosis. J Bone Miner Res. 21(6): 876-885, 2006.
  48. Kondo, N., Tokunaga, K., Ito, T., Arai, K., Amizuka, N., Li, M., Kitahara, H., Ito, M., Naito, M., Jiang, SY.,, Oda, K., Murai, T., Takano, R., Ogose, A., Endo, N.: High dose glucocorticoid hampers bone formation and resorption after bone marrow ablation in rat. Microscopy Research & Technique. 69(10): 839-846, 2006.
  49. Tsukiyama, K., Yamada, Y., Yamada, C., Harada, N., Kawasaki, Y., Ogura, M., Bessho, K., Li, M., Amizuka, N., Sato, M., Udagawa, N., Takahashi, N., Tanaka, K., Oiso, Y., Seito, Y.: Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion. Mol Endocrinol. 20(7): 1644-1651, 2006.　
  50. Sakagami, N., Amizuka, N., Li, M., Takeuchi, K., Hoshino, M., Nakamura, M., Nozawa-Inoue, K., Udagawa, N., Maeda, T.: Reduced Osteoblastic Population and Defective Mineralization in Osteopetrotic (op/op) Mice. Micron. 36 (7-8): 688-695, 2005.　
  51. Shimamura, T., Amizuka, N., Li, M., White, J.H., Henderson, J.E., Oda, K., Singaki, S., Nakajima, T., and Ozawa, H. Histological observations on multiple matrix degradation of osteolytic bone metastasis by breast carcinoma cell line. Biomedical Research. 26(4): 159-172, 2005.
  52. Amizuka, N., Shimomura, J., Li, M., Nasu, M., Maeda, T.: Histological evaluation for “bone quality” on two mouse models with different bone remodeling. J Bone Miner Metab. 23: 43-47, 2005.
  53. Hossain, KS., Amizuka, N., Ikeda, N., Nozawa-Inoue, K., Suzuki, A., Li, M., Takeuchi, K., Aita, M., Kawano, Y., Hoshino, M., Oda, K., Takagi, R., Takeyasu Maeda, T.: Histochemical evidences on the chronological alterations of the hypertrophic zone of mandibular condylar cartilage. Microscopy Research & Technique. 67(6): 325-335, 2005.
  54. Li, M., Amizuka, N., Oda, K., Tokunaga, K., Ito, T., Takeuchi, K., Takagi, R. and Maeda, T.: Histochemical evidence of the initial chondrogenesis and osteogenesis in the periosteum of a rib fractured model: Implications of osteocyte involvement in periosteal chondrogenesis. Microscopy Research & Technique. 64(4): 330-342, 2004.
  55. Asawa, Y., Amizuka, N., Hara, K., Kobayashi, M., Aita, M., Li, M., Kenmotsu, S., Oda, K., Akiyama, Y., and Ozawa, H.: Histochemical evaluation for the biological effect of menatetrenone on metaphyseal trabeculae of ovariectomized rats. Bone. 35(4): 870-880, 2004.
  56. Amizuka, N., Shimomura, J., Li, M., Seki, S., Oda, K., Henderson, J.E., Mizuno, A., Ozawa, H. and Maeda, T.: Defective bone remodeling in osteoprotegerin deficient mice. J. Electron Micro. 52(6): 503-513, 2003.

　　特別講演・シンポジウム講演

  1. Saito H., Takeda S., Takahashi F., Li M., Freitas PHL., Amizuka N.: Eldecalcitol Stimulates ‘Bone Minimodeling’, Focal Bone Formation without Prior Bone Resorption by Osteoclasts, in Rats. The 15th Vitamin D Workshop, Houston, America, 2012.6.20-22, Program & Abstracts pp6: , 2012.
  2. Amizuka N., Hongo H., Sasaki M., Hasegawa T., Freitas PHL., Mori H., Li M.: Assessment of histological alterations in cartilage and extracellular matrix driven by collagen-induced arthritis in Macaca fascicularis. The 1st Bio-Rheumatology International Congress(BRIC2011), Tokyo, Japan, 2011.11.14-16, Arthritis & Research Therapy 14（1）:5-6, 2012.
  3. Li M., Hasegawa T., Sasaki M., Amizuka N.: Histological examination on biomaterials that induce bone regeneration. The 5th China Medicinal Biotech Forum (CMBF2011), Beijing, China, 2011.11.7-9, Program & Abstracts: 206, 2011.
  4. Amizuka N., Sasaki M., Hongo H., Hasegawa T., Li M., Freitas PHL.: Histochemical imaging of bone forming cells. 12th Chitose International Forum on Photonics Science & Technology, Chitose, Hokkaido, 2011.10.13-14, Program & Abstracts: 52, 2011.
  5. Li M.：Invited speaker Histochemical assessment for bone metabolism. The School of Stomatology, Shandong University, Jinan, China, 2011.6.23
  6. Amizuka N, Li M: Histological findings on the biological action of PTH/PTHrP in skeletal tissues.
  7. Hasegawa T, Li M, Sasaki M, Tabata C, Yamamoto T, Amizuka N : Histochemical examination on collagen fibrils in periodontal ligaments of ascorbic acid insufficient od/od rats. International Joint Symposium: The Univeristy of Tokushima, Universitas Gadjah Mada, Niigata University. 18th December, 2010, Denpasar, Bali, Indobesia.
  8. 網塚憲生、李敏啓、山本恒之：「石灰化基質に対する骨細胞の作用」第52回歯科基礎医学会、東京、2010年9月20-22日
  9. Amizuka N, Li M, Freitas PHL, Liu Z, Guo Y, Suzuki R, Yamamoto T: Histological assessment for PTH/PTHrP signaling on osteoblasts. The 14th international congress of endocrinology, Kyoto, March 26-30, 2010, JAPAN, Endocrine J. program & Abstracts S244, 2010.
  10. Sakagami N, Amizuka N, Li M, Takeuchi K, Nakamura H, Udagawa N. Maeda T: Osteoclastic presence is essential for osteoblastic activity: a histolgical study in osteopetrotic (op/op) mice and c-src deficient (c-src-/-) mice. 3rd Hiroshima Conference on Education and Science in Dentistry, Hiroshima, 2009. 11.7-8, Proceedings of 3rd Hiroshima Conference on Education and Science in Dentistry, 80, 2009.
  11. 網塚憲生、長谷川智香、佐々木宗輝、田幡千尋、山本恒之、李　敏啓、和田悟史：　骨細胞の機能における形態学的知見．　シンポジウム「骨基質ミネラル調節における生理学と形態学．」　第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会　横浜　2011年3月30日　プログラム2011：143, 2011.  Amizuka N., Hasegawa T., Sasaki M., Tabata C., Yamamoto T., Li M., Wada S.：Morphological aspects of biological function　of osteocytes. The joint meeting of the 88th annual meeting of the Physiological Society of Japan & the 116th annual meeting of the Japanese association of Anatomists, Yokohama, Japan, 2011.3.28-30, Program: 143, 2011.
  12. 網塚憲生、李　敏啓、山本恒之：　石灰化基質に対する骨細胞の作用．　サテライトシンポジウム「基質からみた硬組織の調節機構．」　第52回歯科基礎医学会学術大会　東京　2010年9月20日　プログラム・抄録集:88, 2010.
  13. 網塚憲生、李　敏啓：骨質を石灰化基質の微細構造から考える. 第29回骨形態計測学会 大阪 2009.
  14. 李　敏啓：形態学から見た骨基質石灰化機構の解析. 第50回歯科基礎医学会総会　サテライトシンポジウム 東京　2008.
  15. 網塚憲生、李　敏啓：「骨評価の最新の知見：骨構造と骨質」モデルマウスにみるカップリングとリモデリング.　第26回骨形態計測学会 新潟 2006.
  16. 網塚憲生、李　敏啓：形態からみた骨吸収とカップリング.　第24回日本骨代謝学会 ミニシンポジウムII 東京 2006.
  17. Norio Amizuka, Minqi Li, Janet Henderson：The PTHrP action on skeletal cells by bipartite pathways．The 16th International Microscopy Congress, symposium B-18, hard tissue. Sapporo, Japan. 9.3-9.8, 2006.
  18. 網塚憲生、李　敏啓、小澤英浩、前田健康：骨転移巣の微細環境における組織学的知見．第25回日本骨形態計測学会年会 東京2005.
  19. 網塚憲生、李　敏啓、小林正敏、原　久仁子、赤羽章司、小澤英浩、秋山康博、前田健康：　骨基質に対するビタミンKの作用―形態学的考察―. 第4回松本ボーンフォーラム 松本歯科大学, 塩尻市 2005.
  20. 李　敏啓 : 肋骨骨折モデルにおける骨膜の初期軟骨形成と骨形成の組織学観察．新潟大学歯学部口腔外科・歯科麻酔科同門会　新潟　2004.