Graduate School of Dental Medicine, Hokkaido University.

Vascular Biology and Molecular Pathology

Achievements

English-language papers (*corresponding author)

2019

  1. Dorcas Akuba Muhyia Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Cong Li, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura, Mohammad Towfik Alam, Kazuyuki Minowa, Nobuo Shinohara, Jin-Min Nam, Yasuhiro Hida, Kyoko Hida：Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment, Cell Communication and Signaling, in press
  2. Nako Maishi.§, Hiroshi Kikuchi.§, Masumi Sato, Hiroko Nagao-Kitamoto, Dorcas A. Annan, Shogo Baba, Takayuki Hojo, Misa Yanagiya, Yusuke Ohba, Genichiro Ishii, Kenkichi Masutomi, Nobuo Shinohara, Yasuhiro Hida, Kyoko Hida * : Development of immortalized human tumor endothelial cells from renal cancer, Int. J. Mol. Sci., equally contributed, 20, 4595, 2019
  3. Toshihiro Kushibiki, Toru Nakamura, Masumi Tsuda, Takahiro Tsuchikawa, Koji Hontani, Kazuho Inoko, Mizuna Takahashi, Toshimichi Asano, Keisuke Okamura, Soichi Murakami, Yo Kurashima, Yuma Ebihara, Takehiro Noji, Yoshitsugu Nakanishi, Kimitaka Tanaka, Nako Maishi, Katsunori Sasaki, Woong-Ryeon Park, Toshiaki Shichinohe, Kyoko Hida, Shinya Tanaka, and Satoshi Hirano：Role of dimerized C16orf74 in aggressive pancreatic cancer: A novel therapeutic target, Mol Cancer Ther, in press
  4. Ahmed Y AlBaloul, Yusuke Sato, Nako Maishi, Kyoko Hida, Hideyoshi Harashima：Two modes of toxicity of lipid nanoparticles containing a pH-sensitive cationic lipid on human A375 and A375-SM melanoma cell lines, BPB Reports, in press
  5. Sakurai Y., Kato A., Hida Y., Hamada J., Maishi N., Hida K., Harashima H.：Synergistic enhancement of cellular uptake with CD44-expressing malignant pleural mesothelioma by combining cationic liposome and hyaluronic acid-lipid conjugate, J Pharm Sci, in press
  6. Yuichi Akatsu, Naoya Takahashi, Yasuhiro Yoshimatsu, Shiori Kimuro, Tomoki Muramatsu, Akihiro Katsura1, Nako Maishi, Hiroshi I. Suzuki, Johji Inazawa, Kyoko Hida, Kohei Miyazono, and Tetsuro Watabe：Fibroblast growth factor signals regulate transforming growth factor-β-induced endothelial-to-myofibroblast transition of tumor endothelial cells via Elk1, Molecular Oncology, 13(8), 1706-1724, 2019

2017

  1. *Hida K.§, Maishi N.§, Akiyama K., Ohmura-Kakutani H., Torii C., Ohga N., Osawa T., Kikuchi H., Morimoto H., Morimoto M., Shindoh M., Shinohara N. and Hida Y.: Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity Show drug resistance, Cancer Sci, 108(11), 2195-2203, 2017
  2. *Hida K. §, Kawamoto T. §, Maishi N., Morimoto M., Akiyama K., Ohga N., Shindoh M., Shinohara N., Hida Y.: miR-145 Promoted Anoikis Resistance in Tumor Endothelial Cells, J Biochem, 162(2), 81-84, 2017
  3. Hojo T. §, Maishi N.§, Towfik AM, Akiyama K., Ohga N., Shindoh M., Hida Y., Minowa K., Fujisawa T., *Hida K.: ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells, Oncotarget, 8(28):45484-45495, 2017
  4. *Hida K., Maishi N.：Abnormalities of tumor endothelial cells and cancer progression, Oral Sci Int, in press
  5. Maishi N., *Hida K.: Tumor endothelial cells accelerate tumor metastasis, Cancer Sci, 108(10), 1921-1926
  6. *Hida K., Kikuchi H., Maishi N., Hida Y：ATP-binding cassette transporters in tumor endothelial cells and resistance to metronomic chemotherapy, Cancer Lett,400, 305-310, 2017
  7. Torii C., Hida Y., Shindoh M., Akiyama K., Ohga N., Maishi N.,Ohiro Y., Ono M., Totsuka Y., Kitagawa Y., Tei K., Sato Y., Hida K.：Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma, Anticancer Res,  37(3), 1219-1225, 2017
  8. Habiba U., *Hida K., Kitamura T., Yanagawa Matsuda A., Higashino F., Ito M Y., Ohiro Y., Totsuka Y., Shindoh M.,：ALDH1 and podoplanin expression patterns predict the risk of malignant transformation in oral leukoplakia, Oncol Lett, 13(1), 321-328, 2017
  9. *Hida K., Maishi N., Dorcas Akuba-Muhyia Annan, Kondoh M., Hojo T., Umma Habiba, Ohga N., Ishikawa K, Sato M., Torii C., Yanagiya M., Morimoto M., Hida Y., Shindoh M.：Aneuploidy of murine immortalized endothelial cell line, MS1，J Oral Biosci，59 (2017), 50-54, 2017

2016

  1. *Hida K., Maishi N., Torii C., Hida Y.: Tumor Angiogenesis—Characteristics of Tumor Endothelial Cells, Int J Clin Oncol, 21(2), 206-212, 2016
  2. *Hida K., Maishi N., Sakurai Y., Hida Y., Harashima H.: Heterogeneity of tumor endothelial cells and drug delivery, Adv Drug Deliv Rev,99(Pt B), 140-147, 2016
  3. Habiba U., Kitamura T., Yanagawa-Matsuda A., Higashino F., Hida K., Totsuka Y., *Shindoh M.: HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions, Oncol Lett, 12(5), 3199-3207, 2016
  4. Hida K., Maishi N., Kawamoto T., Akiyama K., Ohga N., Hida Y., Yamada K., Hojo T., Kikuchi H., Sato M., Torii C., Shinohara N., Shindoh M.：Tumor endothelial cells express high pentraxin 3 levels, Pathol Int, 66(12), 687-694, 2016
  5. Hida K., Maishi N., Torii C., Yanagiya M., Annan Akuba-Muhyia Dorcas., Morimoto M., Alam Mohammad Towfik：Comparison of characteristics of mouse immortalized normal endothelial cells, MS1 and primary cultured endothelial cells, Hokkaido Journal of Dental Science, 37(1)，40-48, 2016
  6. Maishi N., Ohba Y., Akiyama K., Ohga N., Hamada J., Nagao-Kitamoto H., Mohammad Towfik Alam, Yamamoto K., Kawamoto T., Inoue N., Taketomi A., Shindoh M., Hida Y., Hida K.：Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan, Sci Rep, 6, 28039, 2016
  7. Shahrabi-Farahani S., Marina Gallottini, Fabiana Martins, Erik Li, Dayna R. Mudge, Hironao Nakayama, Kyoko Hida, Dipak Panigrahy, Patricia A. D’Amore, Diane R. Bielenberg：The Neuropilin 1 Receptor is Upregulated in Dysplastic Epithelium and Oral Squamous Cell Carcinoma, Am J Pathol, 186(4), 1055-1064

2015

  1. Yamada K., Maishi N., Akiyama K., Alam Mohammad Towfik, Ohga N., Kawamoto T., Shindoh M. Takahashi N., Kamiyama T., Hida Y., Taketomi A. and *Hida K.：CXCL 12-CXCR7 axis is important for tumor endothelial cell angiogenic property, Int J Cancer, 137(12), 2825-2836，2015 (selected as a cover)
  2. Matsumoto R., Tsuda M., Wang Lei.; Maishi N., Abe T., Kimura T., Tanino M., Nishihara H., Hida K., Ohba Y., Shinohara N., Nonomura K., Tanaka S.,：CRK adaptor protein induces epithelial–mesenchymal transition and metastasis of bladder cancer cells via HGF/c-Met feedback loop, Cancer Sci, 106(6), 709-717, 2015
  3. Akiyama K., Ohga N., Hida Y., Maishi N., Ohba Y., Alam Mohammad Towfik, Kawamoto T., Ohmura H., Yamada K., Torii C., Shindoh M. and *Hida K.：Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic activity，Am J Pathol,185(2), 572-580, 2015

2014

  1. Kibria G., Hatakeyama H.,Akiyama K., Hida K. and *Harashima H.: Comparative Study of the Sensitivities of Cancer Cells to Doxorubicin, and Relationships between the Effect of the Drug-Efflux Pump P-gp, Biol. Pharm. Bull, 37(12), 1926–1935, 2014
  2. Akhter A., Hayashi Y., Sakurai Y., Ohga N., Hida K., *Harashima H.: Ligand density at the surface of a nanoparticle and different uptake mechanism: Two important factors for successful siRNA delivery to liver endothelial cells, Int J Pharm, 475 (1-2):227-237, 2014
  3. Ohmura-Kakutani H., Akiyama K., Maishi N., Ohga N., Hida Y., Kawamoto T., Iida J., Shindoh M., Tsuchiya K., Shinohara N., *Hida K.：Identification of Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity and a Highly Angiogenic Phenotype,PLoS ONE,  9(12):e113910, 2014
  4. Ara MN., Matsuda T., Hyodo M, Sakurai Y, Ohga N., Hida K.：Construction of an aptamer modified liposomal system targeted to tumor endothelial cells, Bio Pharm Bull, 37(11):1742-9, 2014
  5. Alam MT， Nagao-Kitamoto H., Ohga N., Akiyama K., Maishi N.,  Kawamoto T., Shinohara N., Taketomi A., Shindoh M., Hida Y. and *Hida K.：Suprabasin as a novel tumor endothelial cell marker, Cancer Sci, 105(12), 1533–1540, 2014
  6. Ara MN., Matsuda T., Hyodo M, Sakurai .Y, Hatakeyama H., Ohga N., Hida K., Harashima H. ：An aptamer ligand based liposomal nanocarrier system that targets tumor endothelial cells，Biomaterials, 35(25), 7110-7120, 2014
  7. Ara MN., Hyodo M., Ohga N., Akiyama K., Hida K., Hida Y., Shinohara N., Harashima H.：Identification and expression of troponin T, a new marker on the surface of cultured tumor endothelial cells by aptamer ligand, Cancer Med, 3(4), 825-834, 2014
  8. Otsubo T., Hida Y., Ohga N., Sato H., Kai T., Matsuki Y., Takasu H., Akiyama K., Maishi N., Kawamoto T., Shinohara N., Nonomura K., *Hida K.：Identification of Novel Targets for Antiangiogenic Therapy by Comparing the Gene Expressions of Tumor and Normal Endothelial Cells, Cancer Sci, 105(5), 560-567, 2014
  9. Habiba U., Kitamura T. Yanagawa-Matsuda A., Hida K., Higashino F., Ohiro Y., Totsuka Y. and Shindoh M.：Cytoplasmic expression of HuR may be a valuable diagnostic tool for determining the potential for malignant transformation of oral verrucous borderline lesions, Oncol Rep, 31(4), 1547-1554, 2014
  10. Sakurai Y., Hatakeyama H., Sato Y., Hyodo M., Akita H.,Ohga N., Hida K., Harashima H.：RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system, J Control Release, 173(10), 110-118, 2014

2013

  1. Kondoh M., Ohga N., Akiyama K., Hida Y., Maishi N., Alam Mohammad Towfik, Inoue N., Shindoh M. and Hida K.：Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment, PLoS ONE, 8(11), e80349, 2013
  2. *Hida K., Ohga N., Akiyama K., Maishi N., Hida Y.：Heterogeneity of tumor endothelial cells, Cancer Sci, 104(11), 1391-1395, 2013
  3. Akhter A., Hayashi Y., Sakurai Y., Ohga N., Hida K., Harashima H.：A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence，Int J Pharm，456(1)，195-201, 2013
  4. Osawa T., Ohga N., Akiyama K., Hida Y., Kitayama K., Kawamoto T., Yamamoto K. , Maishi N., Kondoh M., Onodera Y., Fujie M., Nonomura K., Shindoh M. and Hida K. : Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis, Br J Cancer, 109(8), 2237-2247, 2013
  5. Maishi N., Kawamoto T., Ohga N.,Yamad K., Akiyama K., Yamamoto K. , Osawa T., Hida Y. and *Hida K. : Application of POLARIC™ fluorophores in an in vivo tumor model, Oncol Rep, 30(4), 1695-1700, 2013
  6. Kibria G., Hatakeyama H., Ohga N., Hida K., Harashima H.：The effect of liposomal size on the targeted delivery of doxorubicin to Integrin alpha)v(beta)3-expressing tumor endothelial cells, Biomaterials, 34(22), 5617-5627, 2013
  7. Nagamine K., Kitamura T., Yanagawa -Matsuda A., Ohiro Y., Tei K., Hida K., Higashino F., Totsuka Y. and Shindoh M.： Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma, Oncol Rep, 29(6), 2114-2118, 2013
  8. Yamada Y., Hashida M., Hayashi Y., Tabata M., Hyodo M., Naznin Ara., Ohga N., Hida K., Harashima H.：An approach to transgene expression in liver endothelial cells using a liposome-based gene vector coated with hyaluronic acid, J Pharm Sci,102(9), 3119-3127, 2013
  9. *Hida K., Akiyama K., Ohga N., Maishi N., Hida Y.: Tumor endothelial cells acquire drug resistance in a tumor microenvironment, J Biochem,153(3), 243-249, 2013
  10. Akiyama K., Ohga N., Maishi N., Hida Y., Kitayama K., Kawamoto T., Osawa T., Suzuki Y., Shinohara N., Nonomura K., Shindoh M., *Hida K. : The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma, Pathol Int,63(1), 37-44, 2013 〔PDF〕

2012

  1. Takara K., Hiroto Hatakeyama H., Kibria G., Ohga N., Hida K., *Harashima H.: Size-controlled, dual-ligand modified liposomes that target the tumor vasculature show promise foruse in drug-resistant cancer therapy, J Controlled Release, 162(1), 225-232, 2012
  2. Naznin Ara., Hyodo M., Ohga N., Hida K., Harashima H.: Development of a novel DNA aptamer ligand against primary cultured tumor endothelial cells, PLoS ONE, 7(12), e50174, 2012
  3. Osawa T., Ohga N., Hida Y., Kitayama K., Akiyama K., Onodera Y., Fujie M., Shinohara N., Nonomura K., Shindoh M. , *Hida K.: Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner, Cancer Sci, 103(6), 1038-1044, 2012
  4. Kawamoto T., Ohga N., Akiyama K., Hirata N., Kitahara S, Maishi N., Osawa T., Yamamoto K., Kondoh M., Shindoh M., Hida Y., *Hida K.: Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis, PLoS ONE 7(3) :e34045, 2012
  5. Yamamoto K., Ohga N., Hida Y., Maishi N., Kawamoto T., Kitayama K., Akiyama K., Osawa T., Kondoh M., Matsuda K., Onodera Y., Fujie M., Kaga K., Hirano S, Shinohara N., Shindoh M., *Hida K.: Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells, Br J Cancer, 106(6), 1214-1223, 2012
  6. Maishi N., Ohga N., Hida Y.,　 Akiyama K., Kitayama K., Osawa T., Onodera Y., Nonomura K., Shinohara N., Shindoh M., *Hida K.. : CXCR7 : A novel tumor endothelial marker in renal cell carcinoma, Pathol Int, 62(5), 309-317, 2012
  7. Ohga N.,Ishikawa S., Maishi N., Akiyama K., Hida Y.,　Kawamoto T., Sadamoto Y., Osawa T.,Yamamoto K., Kondoh M., Ohmura H., Shinohara N., Nonomura K., Shindoh M., *Hida K.：Heterogeneity of Tumor Endothelial Cells: Comparison between Tumor Endothelial Cells Isolated from Highly Metastatic and Low Metastatic Tumors, Am J Pathol, 180(3), 1294-1307, 2012
  8. Akiyama K., Ohga N., Hida Y., Kawamoto T., Sadamoto Y., Ishikawa S., Maishi N., Akino T., Kondoh M., Matsuda A., Inoue N., Shindoh M. and *Hida K..: Tumor endothelial cells acquire drug resistance by MDR1 upregulation via VEGF signaling in tumor microenvironment, Am J Pathol, 180(3), 1283-1293, 2012

2011

  1. *Hida K., Kawamoto T., Ohga N., Akiyama K., Hida Y., Shindoh M.: Altered angiogenesis in the tumor microenvironment, Pathol Int, 61(11), 630-637, 2011
  2. Kibria G., Hatakeyama H., Ohga N., Hida K., Harashima H.: Dual-ligand modification of PEGylated liposomes shows better cell selectivity and efficient gene delivery, J Controlled Release, 153(2), 141-148, 2011
  3. Muraki C., Ohga N., Hida Y.,Nishihara H.,Kato Y., Tsuchiya K., Matsuda K., Totsuka Y.,Shindoh M. and *Hida K.: Cyclooxygenase- Int J Cancer,130(1), 59-72, 2011
  4. Kurosu T., Ohga N., Hida Y., Maishi N., Akiyama K., Kakuguchi W., Kuroshima T., Kondo M., Akino T., Totsuka Y., Shindoh M., Higashino F. and *Hida K..: HuR keeps an angiogenic switch on by stabilizing mRNA of VEGF and COX-2 in tumor endothelium,Br J Cancer, 104(5), 819-829, 2011 〔PDF〕
  5. Nitta Y., Hida K., Kitamura T., Higashino F., Ohga N., Fukushima K., Shindoh M.: Phenotype of tumor lymphatic vessels is a prognostic factor in human tongue squamous cell carcinoma, Oncol Lett, 2(1), 79-83, 2011

2010

  1. Higashino F., *Hida K., Kitamura T., Ohga N., Shindoh M.：Aberrant control of transcription and transportation of oncogenic mRNA in carcinogenesis,Oral Sci Int, 7(1), 11-18, 2010
  2. *Hida K., Ohga N., Kurosu T.,Totsuka Y.andShindoh M.: Crosstalk between blood vessels and tumor microenvironment,Oral Sci Int, 7(1), 1-10, 2010
  3. Takara K., Hatakeyama H., Ohga N., Hida K*., Harashima H.: Design of a dual-ligand system using a specific ligand and cell penetrating peptide, resulting in a synergistic effect on selectivity and cellular uptake,Int J Pharm, 396(1-2), 143-148, 2010
  4. Kajimoto K.,Hossen MN.,Hida K., Ohga N., Akita H., Hyodo M., Hida Y. and Harashima H.: Isolation and Culture of Microvascular Endothelial Cells from Murine Inguinal and Epididymal Adipose Tissue, J Immunol Methods, 357(1-2),43-50, 2010
  5. Matsuda K., Ohga N., Hida Y., Muraki C., Kurosu T., Tsuchiya K., Akino T., Shih SC, Totsuka Y., Klagsbrun M., Shindoh M. and *Hida K.：Isolated tumor endothelial cells maintain specific character during long-term culture, Biochem Biophys Res Commun, 394(4), 947- 954, 2010
  6. Suzuki Y., Ohga N., Morishita Y.,Hida K., Miyazono K., and Watabe T.: BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo, J Cell Sci, 123(10), 1684-1692, 2010
  7. Tsuchiya K.,*Hida K., Hida Y., Muraki C.,Ohga N., Kondo T., Miseki T., Nakagawa K., Shindoh M., Harabayashi T., Shinohara N., Nonomura K. and Kobayashi M.: Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progernitor mobilization, Int J Oncol, 36(6), 1379-1386, 2010

2009

  1. *Hida K., Ohga N.,Hida Y. and Shindoh M.: Significance of Antiangiogenic Therapy in Head and Neck Cancer-Heterogeneity of Tumor Endothelium. Jpn Dent Sci Review, 46, 26-32, 2009
  2. Ohga N.,*Hida K., Hida Y., Muraki C., Tsuchiya K., Matsuda K., Ohiro Y., Totsuka Y. and Shindoh M.: Inhibitory Effects ofEpigallocatechin-3 Gallate, a Polyphenol in Green Tea, on Tumor-Associated Endothelial Cells and Endothelial Progenitor Cells. Cancer Sci, 100(10), 1963-1970, 2009
  3. Akino T., *Hida K., Hida Y., Tsuchiya K., Freedman D., Muraki C., Ohga N., Matsuda K., Akiyama K., Harabayashi T., Shinohara N., Nonomura K., Klagsbrun M. and Shindoh M.: Cytogenetic　Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumor. Am J Pathol,175(6), 2657-2667, 2009 〔PDF〕
  4. Tanaka S, Kitamura T, Higashino F, Hida K., Ohiro Y, Ono M, Kobayashi M, Totsuka Y, Shindoh M: Pim-1 activates cell motility that induces malignant phenotype of tongue squamous cell carcinoma. Mol Med Rep, 2(2):313-318, 2009.

Before 2008

  1. Dudley AC., Shih SC., Cliffe AR., Hida K. and Klagsbrun M.: Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine. Br J Cancer, 99(1), 118-125, 2008.
  2. Hata H., Kitamura T., Higashino F., Hida K., Yoshida K., Ohiro Y., Totsuka Y., Kitagawa Y. and Shindoh M.: Expression of E1AF, and ets-oncogene transcription factor, expression highly correlates with malignant phenotype of malignant melanoma through upregulating membrane-type-1 matrix metalloproteinase gene. Oncol Rep, 19(5), 1093-1098, 2008
  3. *Hida K., Hida Y. an Shindoh M.: Understanding Abnormality of Tumor Endothelial Cells to Develop Ideal Anti-angiogenic Therapies. Cancer Sci. 99 (3), 459-466, 2008
  4. Amin D., Hida K., Bielenberg D. and Klagsbrun M.:Expression of epidermal growth factor (EGF) receptor but not ErbB3 in Tumor endothelial cells coincides with responsiveness to EGF and sensitivity to EGFR kinase inhibitors. Cancer Res., 66 (4), 2173-2180, 2006
  5. *Hida K.. and Klgsbrun M.: A new perspective on tumor endothelial cells; Unexpected Chromosome and centrosome abnormalities. Cancer Res, 65 (7), 1-4, 2005
  6. Hida K., Hida Y., Amin D., Flint A., Panigrahy D., Morton C. and Klagsbrun M.: Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res., 64(22), 8249-8255, 2004 〔PDF〕
  7. Shindoh M., Adachi M., Higashino F., Yasuda M., Hida K., Nishioka K., Takayama S., Reed J.C., Imai K., Totsuka Y. and Kohgo T.:BAG-1 expression correlates highly with the malignant potential in early lesions (T1 and T2) of oral squamous cell carcinoma. Oral Oncol, 36(5), 444-449, 2000
  8. Hanzawa M., Shindoh M., Higashino F., Yasuda,M., Hida K., Kohgo T., Nakamura M., Notani K., Totsuka Y., Yoshida K. and Fujinaga K.: Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma (SCC) cell invasion by activating matrix metalloproteinase genes. Carcinogenesis, 21(6), 1079-1085, 2000
  9. Hida K., Shindoh M., Yoshida K., Yasuda M., Hanzawa M., Funaoka K., Kohgo T., Amemiya A., Totsuka Y. and Fujinaga K.: Antisense E1AF transfection restrains oral cancer invasion by reducing MMPs activities. Am J Pathol, 150, 2125-2132, 1997
  10. Hida K., Shindoh M., Yoshida K., Kudoh A., Funaoka K., Kohgo T., Fujinaga K. and Totsuka Y.: Expression of E1AF, an ets-family transcription factor, is correlated with the invasive phenotype of oral squamous cell carcinomas. Oral Oncol, 33(6), 426-430, 1997
  11. Funaoka K., Shindoh M.,Yoshida K.,Hanzawa M., Hida K.,Nishikata S., Totsuka Y. and Fijinaga K.: Activation of the p21(Waf1/Cip1) promoter by the ets oncogene family transcription factor E1AF, Biochem Biophys Res Commun, 236(1), 79-82, 1997
  12. Shindoh M., Higashino F., Kaya M., Yasuda M., Funaoka K., Hanzawa M., Hida K., Kohgo T, Amemiya A., Yoshida K. and Fujinaga K.: Correlated expression of matrix metalloproteinases and ets-family transcription factor E1A-F in invasive oral-squamous-cell-carcinoma-derived cell lines. Am J Pathol, 148(3), 693-700, 1996.