{"id":16,"date":"2019-01-16T16:12:29","date_gmt":"2019-01-16T07:12:29","guid":{"rendered":"https:\/\/www.den.hokudai.ac.jp\/vascular-biol-pathol-test\/?page_id=16"},"modified":"2019-01-23T15:51:22","modified_gmt":"2019-01-23T06:51:22","slug":"research-details","status":"publish","type":"page","link":"https:\/\/www.den.hokudai.ac.jp\/vascular-biol-pathol\/research-details\/","title":{"rendered":"\u7814\u7a76\u5185\u5bb9"},"content":{"rendered":"

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\u73fe\u5728\u6559\u5ba4\u3067\u884c\u308f\u308c\u3066\u3044\u308b\u7814\u7a76\u6982\u8981\u306f<\/p>\n

    \n
  1. \u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u7570\u5e38\u6027\u89e3\u660e\u3068\u6cbb\u7642\u6cd5\u958b\u767a<\/li>\n
  2. \u304c\u3093\u5fae\u5c0f\u74b0\u5883\u3068\u304c\u3093\u60aa\u6027\u5316\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e<\/li>\n
  3. \u5e79\u7d30\u80de\u69d8\u8840\u7ba1\u5185\u76ae\u7d30\u80de<\/li>\n
  4. \u8840\u7ba1\u518d\u751f<\/li>\n
  5. RNA\u3068\u7d30\u80de\u304c\u3093\u5316\u3068\u306e\u95a2\u9023<\/li>\n
  6. \u816b\u760d\u6eb6\u89e3\u30a6\u30a4\u30eb\u30b9\u306e\u958b\u767a\u3068\u305d\u306e\u5fdc\u7528\u3067\u3059 \uff08\u8a73\u7d30\u306f\u6559\u5ba4\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u3092\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\uff09<\/li>\n<\/ol>\n

    \u6559\u5ba4\u306b\u306f\u6b6f\u5b66\u90e8\u306e\u5927\u5b66\u9662\u751f\u306e\u307f\u306a\u3089\u305a\uff0c\u533b\u5b66\u90e8\u3084\u4ed6\u5b66\u90e8\u306e\u51fa\u8eab\u306e\u5b66\u90e8\u751f\u30fb\u5927\u5b66\u9662\u751f\uff0c\u7559\u5b66\u751f\u304c\u5728\u7c4d\u3057\uff0c\u65e5\u3005\u30a2\u30af\u30c6\u30a3\u30d6\u306b\u7814\u7a76\u3092\u884c\u3044\uff0c\u5b66\u3093\u3067\u3044\u307e\u3059\uff0e\u7686\u69d8\u306e\u6765\u8a2a\u3092\u6b53\u8fce\u3057\u307e\u3059\u306e\u3067\uff0c\u3044\u3064\u3067\u3082\u6559\u5ba4\u306b\u7acb\u3061\u5bc4\u3063\u3066\u304f\u3060\u3055\u3044\uff0e<\/p>\n

    \u7814\u7a76\u80cc\u666f<\/h3>\n

    \uff11\uff0e\u8840\u7ba1\u306b\u3064\u3044\u3066<\/h4>\n

    \u8840\u7ba1\u306f\u5168\u8eab\u306b\u5e83\u304f\u5206\u5e03\u3057\uff0c\u7d44\u7e54\u306b\u8840\u6db2\u3084\u9178\u7d20\uff0c\u6804\u990a\u7d20\u306a\u3069\u3092\u904b\u3076\u3060\u3051\u3067\u306f\u306a\u304f\uff0c\u7d44\u7e54\u306e\u767a\u751f\u904e\u7a0b\u30fb\u81d3\u5668\u5f62\u6210\u30fb\u7dad\u6301\u3084\u69d8\u3005\u306a\u75be\u60a3\u306e\u767a\u75c7\u3084\u9032\u884c\u306b\u3082\u591a\u5f69\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\uff0e\u4f8b\u3048\u3070\u65e5\u672c\u4eba\u306e\u6b7b\u56e0\u7b2c\uff12\u4f4d\uff0c\uff14\u4f4d\uff082012\u5e74\uff09\u3092\u5360\u3081\u308b\u5fc3\u75be\u60a3\u3068\u8133\u8840\u7ba1\u969c\u5bb3\u306e\u591a\u304f\u306f\u8840\u7ba1\u306e\u75c5\u5909\u306b\u8d77\u56e0\u3057\uff0c\u307e\u305f\uff0c\u65e5\u672c\u4eba\u306e\u6b7b\u56e0\u7b2c1\u4f4d\u3067\u3042\u308a\uff0c\u4eca\u3084\u56fd\u6c11\u306e\uff13\u4eba\u306b\uff11\u4eba\u304c\u767a\u75c7\u3059\u308b\u304c\u3093\u306e\u9032\u5c55\u306b\u3082\u8840\u7ba1\u306f\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\uff0e<\/p>\n

    \u8840\u7ba1\u306e\u69cb\u9020\u306f\u5185\u8154\u3092\u4e00\u5c64\u306b\u304a\u304a\u3046\u5185\u76ae\u7d30\u80de\u3068\uff0c\u305d\u308c\u3092\u5916\u5074\u304b\u3089\u53d6\u308a\u5dfb\u304d\u8840\u7ba1\u69cb\u9020\u306e\u652f\u6301\u3084\u53ce\u7e2e\u30fb\u5f1b\u7de9\u3092\u884c\u3046\u58c1\u7d30\u80de\uff08\u6bdb\u7d30\u8840\u7ba1\u306b\u304a\u3044\u3066\u306f\u30da\u30ea\u30b5\u30a4\u30c8\uff0c\u52d5\u9759\u8108\u306b\u304a\u3044\u3066\u306f\u5e73\u6ed1\u7b4b\u7d30\u80de\uff09\u306e\uff12\u7a2e\u985e\u306e\u7d30\u80de\u304b\u3089\u306a\u308a\u307e\u3059\uff0e\u65e2\u5b58\u306e\u8840\u7ba1\u304b\u3089\u5185\u76ae\u7d30\u80de\u304c\u523a\u6fc0\u306b\u5fdc\u3058\u3066\u65b0\u305f\u306a\u7ba1\u8154\u5f62\u6210\u304c\u304a\u3053\u308b\u3053\u3068\u3092\u8840\u7ba1\u65b0\u751f (angiogenesis) \u3068\u3044\u3044\u307e\u3059\uff0e\u3053\u306e\u3068\u304d\u65e2\u5b58\u306e\u8840\u7ba1\u304b\u3089\u767a\u82bd\u3059\u308b\u5185\u76ae\u7d30\u80de\u306f\uff0c\u5148\u7aef\u306e\u904a\u8d70\u80fd\u304c\u9ad8\u3044tip \u7d30\u80de\u306b\u5148\u5c0e\u3055\u308c\uff0c\u3042\u3068\u306b\u7d9a\u304fstalk\u7d30\u80de\u3055\u3089\u306b\u306fphalanx\u7d30\u80de\u306b\u3088\u308a\u5143\u306e\u8840\u7ba1\u3068\u63a5\u7d9a\u3055\u308c\u307e\u3059\uff0e\u8840\u7ba1\u306f\u5185\u76ae\u7d30\u80de\u3060\u3051\u3067\u5f62\u6210\u3055\u308c\u3066\u3044\u308b\u72b6\u614b\u3067\u306f\u4e0d\u5b89\u5b9a\u3067\u5468\u56f2\u306b\u58c1\u7d30\u80de\u3068\u3088\u3070\u308c\u308b\u8840\u7ba1\u5e73\u6ed1\u7b4b\u3084\u30da\u30ea\u30b5\u30a4\u30c8\u306e\u88cf\u6253\u3061\u304c\u3067\u304d\u3066\u6210\u719f\u5316\u3057\uff0c\u5927\u4e2d\u5c0f\u306e\u5f84\u304c\u7570\u306a\u308b\u8840\u7ba1\u306b\u3088\u3063\u3066\u968e\u5c64\u304c\u3067\u304d\u307e\u3059\uff0e<\/p>\n

    \uff12\uff0e\u816b\u760d\u8840\u7ba1\u65b0\u751f\u306b\u3064\u3044\u3066<\/h4>\n

    \u6210\u4f53\u3067\u304a\u3053\u308b\u8840\u7ba1\u65b0\u751f\u306f\uff0c\u304c\u3093\u3084\u5275\u50b7\u6cbb\u7652\u306e\u969b\u306a\u3069\u865a\u8840\u306b\u9665\u3063\u305f\u7d44\u7e54\u306b\u304a\u3044\u3066\u4f4e\u9178\u7d20\u3084\u8840\u7ba1\u5185\u76ae\u5897\u6b96\u56e0\u5b50 (vascular endothelial growth factor: VEGF) \u306a\u3069\u3044\u304f\u3064\u304b\u306e\u8840\u7ba1\u5185\u76ae\u306e\u5897\u6b96\u3092\u523a\u6fc0\u3059\u308b\u56e0\u5b50\uff08\u8840\u7ba1\u65b0\u751f\u4fc3\u9032\u56e0\u5b50\uff09\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u307e\u3059\uff0e<\/p>\n

    \u6210\u4f53\u306b\u304a\u3051\u308b\u75c5\u7684\u306a\u8840\u7ba1\u65b0\u751f\u306e\u3046\u3061\uff0c\u6700\u3082\u91cd\u8981\u306a\u3082\u306e\u306e\u3072\u3068\u3064\u306b\u816b\u760d\u8840\u7ba1\u65b0\u751f\uff08Tumor angiogenesis\uff09\u304c\u3042\u308a\u307e\u3059\uff0e\u304c\u3093\u7d30\u80de\u306f\u81ea\u3089\u306e\u5897\u6b96\u306b\u5fc5\u8981\u306a\u9178\u7d20\u30fb\u6804\u990a\u306e\u4f9b\u7d66\u3092\u5f97\u308b\u305f\u3081\u306b\u8840\u7ba1\u65b0\u751f\u56e0\u5b50\u3092\u653e\u51fa\u3057\uff0c\u8840\u7ba1\u65b0\u751f\u3092\u76db\u3093\u306b\u8a98\u5c0e\u3057\u307e\u3059\uff0e\u3053\u306e\u3088\u3046\u306b\u3057\u3066\u65b0\u305f\u306b\u5f62\u6210\u3055\u308c\u305f\u816b\u760d\u8840\u7ba1\u306f\u304c\u3093\u306e\u9032\u5c55\u3084\u8ee2\u79fb\u306b\u975e\u5e38\u306b\u91cd\u8981\u3067\u3059\uff0e<\/p>\n

    \u4f4e\u9178\u7d20\u3084\u304c\u3093\u907a\u4f1d\u5b50\u306e\u6d3b\u6027\u5316\u3084\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u3082VEGF\u306e\u767a\u73fe\u306f\u4ea2\u9032\u3057\u307e\u3059\uff0e\u307e\u305f\u8840\u7ba1\u65b0\u751f\u4fc3\u9032\u56e0\u5b50\u306b\u306fVEGF\u306e\u307b\u304b\uff0cbasic fibroblast growth factor (bFGF), angiopoietins, hepatocyte growth factor (HGF), EGF, placental-derived growth factor (PlGF) \u306a\u3069\u3082\u3042\u308a\uff0c \u304c\u3093\u3067\u306f\u3053\u306e\u3088\u3046\u306a\u8840\u7ba1\u65b0\u751f\u56e0\u5b50\u304c\u904e\u5270\u306b\u306a\u3063\u3066\u3044\u307e\u3059\uff0e\u3055\u3089\u306b\u304c\u3093\u5fae\u5c0f\u74b0\u5883\u5185\u3067\u306f\u5185\u56e0\u6027\u306e\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u56e0\u5b50\uff0c\u30c8\u30ed\u30f3\u30dc\u30b9\u30dd\u30f3\u30b8\u30f3\u2212\uff11 (thrombospoidins-1:TSP-1) \u3084\u30cd\u30ac\u30c6\u30a3\u30d6\u5236\u5fa1\u56e0\u5b50\u3068\u3057\u3066 Vasohibin\u3084Down syndrome critical region-1 (DSCR-1) \u306a\u3069\u3082\u5206\u6ccc\u3055\u308c\u3066\u3044\u307e\u3059\uff0e\u3055\u3089\u306b\uff0c\u816b\u760d\u8840\u7ba1\u304c\u5206\u5e03\u3057\u3066\u3044\u308b\u304c\u3093\u9593\u8cea\u306b\u306f\u69d8\u3005\u306a\u7d30\u80de\u304c\u591a\u6570\u6d78\u6f64\u3057\u3066\u3044\u307e\u3059\u304c\uff0c\u3053\u308c\u3089\u306e\u9593\u8cea\u7d30\u80de\u3082\u8840\u7ba1\u65b0\u751f\u4fc3\u9032\u56e0\u5b50\u3092\u7523\u751f\u3057\uff0c\u816b\u760d\u8840\u7ba1\u65b0\u751f\u3092\u52a9\u9577\u3057\u307e\u3059\uff0e\u3053\u306e\u3088\u3046\u306b\uff0c\u304c\u3093\u306e\u8840\u7ba1\u65b0\u751f\u306f\u8907\u6570\u306e\u8840\u7ba1\u65b0\u751f\u4fc3\u9032\u56e0\u5b50\u3068\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u56e0\u5b50\u306e\u30d0\u30e9\u30f3\u30b9\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u8907\u96d1\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u304a\u3053\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f \uff0e<\/p>\n

    \uff13\uff0e\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u7642\u6cd5\u306b\u3064\u3044\u3066<\/h4>\n

    \u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u7642\u6cd5\u306f\uff0c\u304c\u3093\u3092\u990a\u3046\u8840\u7ba1\u3092\u6a19\u7684\u3068\u3057\u304c\u3093\u3092\u5175\u7ce7\u653b\u3081\u306b\u3057\u3088\u3046\u3068\u3044\u3046\u65b0\u3057\u3044\u304c\u3093\u306e\u6cbb\u7642\u6cd5\u3067\uff0c1971\u5e74\uff0c\u5c0f\u5150\u5916\u79d1\u533b\u3067\u3042\u3063\u305fFolkman\u535a\u58eb\u306b\u3088\u3063\u3066\u521d\u3081\u3066\u63d0\u5531\u3055\u308c\u307e\u3057\u305f\uff0e\u5f7c\u306f\u300c\u3059\u3079\u3066\u306e\u304c\u3093\u7d30\u80de\u306f\u8840\u7ba1\u65b0\u751f\u306b\u4f9d\u5b58\u3057\u3066\u3044\u308b\u306e\u3067\uff0c\u8840\u7ba1\u65b0\u751f\u3092\u963b\u5bb3\u3059\u308c\u3070\u304c\u3093\u7d44\u7e54\u3092\u7e2e\u5c0f\uff0c\u6b7b\u6ec5\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\uff0e\u3055\u3089\u306b\u8840\u7ba1\u5185\u76ae\u306f\u6b63\u5e38\u7d30\u80de\u3067\u3042\u308a\u907a\u4f1d\u5b66\u7684\u306b\u5b89\u5b9a\u3067\uff0c\u304c\u3093\u7d30\u80de\u306e\u3088\u3046\u306b\u85ac\u5264\u62b5\u6297\u6027\u3092\u7372\u5f97\u3059\u308b\u3053\u3068\u306f\u306a\u3044\u306e\u3067\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u9069\u3057\u3066\u3044\u308b\uff0e\u300d\u3068\u8003\u3048\u307e\u3057\u305f\uff0e\u3053\u306e\u3088\u3046\u306a\u6982\u5ff5\u304b\u3089\u751f\u307e\u308c\u305f\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u5264\u306e\u306a\u304b\u3067\u3082\u6700\u3082\u6709\u540d\u306a\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u5264\uff1a\u30d9\u30d0\u30b7\u30c4\u30de\u30d6\u306f\uff0c\u816b\u760d\u304a\u3088\u3073\u9593\u8cea\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u8840\u7ba1\u65b0\u751f\u3092\u8a98\u5c0e\u3059\u308bVEGF\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u906e\u65ad\u3059\u308b\uff0c\u30d2\u30c8VEGF (Vascular Endothelial cell Growth Factor) \u306e\u4e2d\u548c\u6297\u4f53\u3067\u3059\uff0e\u4ed6\u306b\u3082\u30bd\u30e9\u30d5\u30a7\u30cb\u30d6\uff0c\u30b9\u30cb\u30c1\u30cb\u30d6\u3068\u3044\u3063\u305fVEGF\u306e\u53d7\u5bb9\u4f53VEGF receptor (VEGFR) \u3092\u6a19\u7684\u3068\u3057\u305f\u69d8\u3005\u306atyrosine kinase inhibitor\u304c\u958b\u767a\u3055\u308c\u81e8\u5e8a\u5fdc\u7528\u3055\u308c\uff0c\u591a\u304f\u306e\u304c\u3093\u60a3\u8005\u306e\u4e88\u5f8c\u3092\u6539\u5584\u3057\u3066\u3044\u307e\u3059\uff0e\u73fe\u5728\uff0c\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u5264\u306f\u8840\u7ba1\u65b0\u751f\u3092\u6291\u3048\uff0c\u6804\u990a\u3084\u9178\u7d20\u306e\u4f9b\u7d66\u8def\u3092\u7d76\u3063\u3066\u300c\u304c\u3093\u3092\u5175\u7ce7\u653b\u3081\u300d\u306b\u3059\u308b\u3068\u3044\u3063\u305f\u76ee\u7684\u306e\u307b\u304b\uff0c\u904e\u5270\u306aVEGF\u523a\u6fc0\u306b\u3088\u308a\u8106\u5f31\u3067\u3082\u308c\u3084\u3059\u3044\u816b\u760d\u8840\u7ba1\u306e\u69cb\u9020\u3092\u6539\u5584\u3057\uff0c\u6297\u304c\u3093\u5264\u306a\u3069\u306e\u85ac\u5264\u304c\u9001\u9054\u3055\u308c\u3084\u3059\u3044\u3088\u3046\u306b\u3059\u308b\u3068\u3044\u3063\u305f\u300c\u816b\u760d\u8840\u7ba1\u306e\u6b63\u5e38\u5316\u300d\u3068\u3044\u3046\u76ee\u7684\u306b\u3082\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\uff0e<\/p>\n

    \uff14\uff0e\u6b63\u5e38\u8840\u7ba1\u3068\u816b\u760d\u8840\u7ba1\u306e\u69cb\u9020\u306e\u9055\u3044<\/h4>\n

    \u524d\u8ff0\u306e\u3088\u3046\u306b\uff0c\u73fe\u5b58\u306e\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u5264\u306f\u304c\u3093\u6cbb\u7642\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\uff0e\u3057\u304b\u3057\u3053\u306e\u6cbb\u7642\u6cd5\u306b\u3082\u3044\u304f\u3064\u304b\u306e\u554f\u984c\u70b9\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\uff0e\u305d\u306e\u3072\u3068\u3064\u306b\uff0c\u9ad8\u8840\u5727\u3084\u8840\u6813\u75c7\uff0c\u6d88\u5316\u7ba1\u7a7f\u5b54\u3068\u3044\u3063\u305f\u526f\u4f5c\u7528\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3059\uff0e\u3053\u308c\u3089\u306e\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u5264\u306e\u591a\u304f\u306f\u6b63\u5e38\u8840\u7ba1\u5185\u76ae\u306e\u751f\u5b58\uff0c\u7dad\u6301\u306b\u5fc5\u9808\u3067\u3042\u308bVEGF\u30b7\u30b0\u30ca\u30eb\u3092\u906e\u65ad\u3059\u308b\u305f\u3081\uff0c\u6b63\u5e38\u8840\u7ba1\u306b\u5bfe\u3059\u308b\u50b7\u5bb3\u304b\u3089\u304a\u3053\u308b\u526f\u4f5c\u7528\u3060\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff0e<\/p>\n

    \u4e00\u65b9\uff0c\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u7642\u6cd5\u306e\u6a19\u7684\u3067\u3042\u308b\u816b\u760d\u8840\u7ba1\u306f\uff0c\u6b63\u5e38\u8840\u7ba1\u3068\u6bd4\u8f03\u3057\u75c5\u7406\u7d44\u7e54\u5b66\u7684\u306b\u591a\u304f\u306e\u70b9\u3067\u7570\u306a\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff0e\u4f8b\u3048\u3070\uff0c\u816b\u760d\u8840\u7ba1\u306b\u304a\u3044\u3066\u306f\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u540c\u58eb\u306e\u63a5\u7740\u304c\u758e\u3067\u3042\u308a\uff0c\u8840\u7ba1\u306e\u58c1\u7d30\u80de\u3068\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3068\u306e\u63a5\u7740\u304c\u758e\u3067\u3042\u308b\u305f\u3081\u8840\u7ba1\u306e\u900f\u904e\u6027\u304c\u4ea2\u9032\u3057\u3066\u3044\u308b\u3053\u3068\uff0c\u8840\u7ba1\u306e\u57fa\u5e95\u819c\u306e\u69cb\u9020\u3082\u7570\u5e38\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff0e\u3053\u308c\u3089\u7570\u5e38\u306a\u8840\u7ba1\u69cb\u9020\u306f\uff0c\u816b\u760d\u8840\u7ba1\u306e\u4e71\u96d1\u3067\u4e0d\u898f\u5247\u306a\u8d70\u884c\uff0c\u3055\u3089\u306b\u8840\u6d41\u306e\u3088\u3069\u307f\u306a\u3069\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\uff0e\u305d\u306e\u305f\u3081\uff0c\u304c\u3093\u7d44\u7e54\u3067\u306f\u8840\u7ba1\u304c\u8c4a\u5bcc\u3067\u3042\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u8840\u6d41\u304c\u5c11\u306a\u304f\uff0c\u304c\u3093\u306e\u3055\u3089\u306a\u308b\u60aa\u6027\u5316\u3084\u85ac\u5264\u8010\u6027\u306a\u3069\u306e\u539f\u56e0\u3068\u306a\u308b\u4f4e\u9178\u7d20\u72b6\u614b\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\uff0e<\/p>\n

    \u79c1\u9054\u306e\u7814\u7a76\u5185\u5bb9<\/h3>\n

    \u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u7570\u5e38\u6027\u306e\u767a\u898b<\/h4>\n

    \u816b\u760d\u8840\u7ba1\u65b0\u751f\u7814\u7a76\u304c\u306f\u3058\u307e\u3063\u305f\u5f53\u521d\u306f\uff0c\u304c\u3093\u306e\u8840\u7ba1\u304c\u6b63\u5e38\u306e\u8840\u7ba1\u3068\u7570\u306a\u308b\u3068\u306f\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\uff0e\u4e0a\u8ff0\u306e\u3088\u3046\u306b\u8840\u7ba1\u306e\u69cb\u9020\u306e\u9055\u3044\u304b\u3089\uff0c\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u3082\u9055\u3044\u304c\u3042\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u306f\u3058\u3081\u307e\u3057\u305f\u304c\uff0c2000\u5e74\u904e\u304e\u307e\u3067\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u751f\u7269\u50cf\u306f\u672a\u77e5\u306e\u307e\u307e\u3067\uff0c\u8840\u7ba1\u7814\u7a76\u306b\u306f\u5206\u96e2\u57f9\u990a\u306e\u6bd4\u8f03\u7684\u5e73\u6613\u306a\u81cd\u5e2f\u9759\u8108\u3084\u76ae\u819a\u6bdb\u7d30\u8840\u7ba1\u306a\u3069\u304b\u3089\u5206\u96e2\u3055\u308c\u305f\u6b63\u5e38\u8840\u7ba1\u5185\u76ae\u7d30\u80de (Normal endothelial cell: NEC\uff09 \u304c\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u304d\u307e\u3057\u305f\uff0e<\/p>\n

    \u3057\u304b\u3057\uff64\u304c\u3093\u306e\u8840\u7ba1\u306f\u6b63\u5e38\u7d44\u7e54\u306e\u8840\u7ba1\u3068\u306f\u5927\u304d\u304f\u7570\u306a\u308b\u74b0\u5883\u306b\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\uff0e\u79c1\u305f\u3061\u306f\u4e16\u754c\u306b\u5148\u99c6\u3051\u3066\u300c\u304c\u3093\u306e\u8840\u7ba1\u3092\u69cb\u6210\u3059\u308b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u300d\uff1a\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de (Tumor endothelial cell: TEC) \u306e\u5206\u96e2\u57f9\u990a\u3092\u304a\u3053\u306a\u3044\uff0c\u7814\u7a76\u3092\u9032\u3081\u3066\u304d\u307e\u3057\u305f\uff0e\u6b63\u5e38\u8840\u7ba1\u5185\u76ae\u7d30\u80de (Normal endothelial cell: NEC) \u3068\u7570\u306a\u308b\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u7279\u6027\u3084\u6a19\u7684\u5206\u5b50\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308c\u3070\uff0c\u6b63\u5e38\u8840\u7ba1\u3092\u50b7\u5bb3\u3059\u308b\u3053\u3068\u306a\u304f\u304c\u3093\u306e\u8840\u7ba1\u306e\u307f\u3092\u653b\u6483\u3059\u308b\u65b0\u3057\u3044\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u5264\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\uff0e<\/p>\n

    \u79c1\u305f\u3061\u306f\u3053\u308c\u307e\u3067\uff0c\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u7570\u5e38\u6027\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u884c\u3044\uff0c\u591a\u304f\u306e\u77e5\u898b\u3092\u5f97\u3066\u3044\u307e\u3059\uff0e<\/p>\n

    \u73fe\u5728\uff0c\u5177\u4f53\u7684\u306b\u306f\u4e0b\u8a18\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u4e2d\u5fc3\u306b\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\uff0e<\/p>\n

      \n
    1. \u816b\u760d\u8840\u7ba1\u5185\u76ae\u306e\u7279\u6027\u89e3\u660e\u304b\u3089\u7279\u7570\u7684\u306a\u963b\u5bb3\u5264\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76<\/li>\n
    2. \u816b\u760d\u8840\u7ba1\u5185\u76ae\u306e\u591a\u69d8\u6027\u89e3\u660e<\/li>\n
    3. \u816b\u760d\u8840\u7ba1\u5185\u76ae\u304c\u7570\u5e38\u6027\u3092\u7372\u5f97\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u6790\uff08\u304c\u3093\u5fae\u5c0f\u74b0\u5883\u306e\u89b3\u70b9\u304b\u3089\uff09<\/li>\n
    4. \u304c\u3093\u5e79\u7d30\u80de\uff0c\u304c\u3093\u306e\u6d78\u6f64\u8ee2\u79fb\u306b\u304a\u3051\u308b\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u6a5f\u80fd\u89e3\u6790<\/li>\n<\/ol>\n

      \uff11\uff0e\u816b\u760d\u8840\u7ba1\u5185\u76ae\u306e\u7279\u6027\u89e3\u660e\u304b\u3089\u7279\u7570\u7684\u306a\u963b\u5bb3\u5264\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76<\/h4>\n

      \u3053\u308c\u307e\u3067\u308f\u308c\u308f\u308c\u306f\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u304c\u6b63\u5e38\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3068\u69d8\u3005\u306a\u70b9\u3067\u7570\u306a\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u3066\u304d\u307e\u3057\u305f\uff0e\u4f8b\u3048\u3070\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306f\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u7570\u306a\u308b\u3053\u3068\uff0c\u8840\u7ba1\u65b0\u751f\u80fd\u304c\u4ea2\u9032\u3057\u3066\u3044\u308b\u3053\u3068 (Matsuda,\u00a0Biochem Biophys Res Commun\u00a02010) \u3092\u5831\u544a\u3057\u3066\u304d\u307e\u3057\u305f\uff0e\u3055\u3089\u306b\u304c\u3093\u9593\u8cea\u306b\u304a\u3051\u308b\u5f53\u6642\u306e\u6982\u5ff5\u306b\u53cd\u3057\uff0c\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u67d3\u8272\u4f53\u7570\u5e38\u304c\u3042\u308b\u3053\u3068\u3092\u521d\u3081\u3066\u793a\u3057\u307e\u3057\u305f (Hida, Cancer Res 2004 \u30cf\u30a4\u30e9\u30a4\u30c8\u30fb\u8868\u7d19\u306b\u9078\u51fa)\uff0e\u305d\u306e\u5f8c\uff0c\u30de\u30a6\u30b9\u306e\u307f\u306a\u3089\u305a\u30d2\u30c8\u306b\u304a\u3044\u3066\u3082\u305d\u306e\u3088\u3046\u306a\u7570\u5e38\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f (Akino, Am J Pathol 2009)\uff0e\u3055\u3089\u306b\u89e3\u6790\u3092\u9032\u3081\u3066\u3044\u304f\u3068\uff0c\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u304a\u3044\u3066\u306fSca-1, CD90\u306a\u3069\u306e\u5e79\u7d30\u80de\u30de\u30fc\u30ab\u30fc\u306e\u767a\u73fe\u304c\u9ad8\u304f\uff0c\u9aa8\u5206\u5316\u80fd\u304c\u3042\u308b\u3053\u3068 (Ohga, Am J Pathol 2012) \u306a\u3069\u3082\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\uff0e\u3055\u3089\u306b\u816b\u760d\u8840\u7ba1\u5185\u76ae\u306f\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u306e\u767a\u73fe\u304c\u9ad8\u304f\u85ac\u5264\u8010\u6027\u3092\u7372\u5f97\u3057\u3066\u3044\u308b (Akiyama, Am J Pathol 2012) \u3053\u3068\u306a\u3069\u3082\u898b\u51fa\u3057\u307e\u3057\u305f\uff0e\u3053\u306e\u3088\u3046\u306a\u816b\u760d\u8840\u7ba1\u306b\u304a\u3051\u308b\u6b63\u5e38\u3068\u306e\u9055\u3044\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\uff0c\u816b\u760d\u8840\u7ba1\u306b\u7279\u7570\u7684\u306a\u85ac\u5264\u3092\u958b\u767a\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\uff08\u4e0b\u56f3)\uff0e\u3053\u308c\u307e\u3067\uff0c\u5206\u96e2\u3057\u305f\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3068\u6b63\u5e38\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3092\u7528\u3044\u3066\u305d\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u6bd4\u8f03\u3057\uff0c\u816b\u760d\u8840\u7ba1\u5185\u76ae\u306b\u304a\u3044\u3066\u6709\u610f\u306b\u767a\u73fe\u304c\u9ad8\u3044\u3082\u306e\u3067\u304b\u3064\uff0c\u816b\u760d\u8840\u7ba1\u5185\u76ae\u306e\u6a5f\u80fd\uff08\u9ad8\u3044\u751f\u5b58\u80fd\u3084\uff64\u904a\u8d70\u80fd\u306a\u3069\uff09\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3082\u306e\u3092\u7d5e\u308a\u8fbc\u307f\u307e\u3057\u305f\uff0e\u3053\u308c\u3089\u306e\u5206\u5b50\u306f\u30de\u30a6\u30b9\u306e\u816b\u760d\u3060\u3051\u3067\u306f\u306a\u304f\uff0c\u30d2\u30c8\u306e\u304c\u3093\u306b\u304a\u3044\u3066\u3082\u767a\u73fe\u304c\u4ea2\u9032\u3057\u3066\u304a\u308a\uff0c\u65b0\u3057\u3044\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u7642\u6cd5\u306e\u6a19\u7684\u3068\u3057\u3066\u6709\u671b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\uff0e\u3053\u308c\u307e\u3067\u816b\u760d\u8840\u7ba1\u5185\u76ae\u306b\u304a\u3044\u3066\u767a\u73fe\u304c\u4ea2\u9032\u3057\u3066\u3044\u308b\u5206\u5b50\uff0cBiglycan (Yamamoto, Birt J Cancer 2012), Ptgir (Osawa, Cancer Sci 2012), COX-2 (Muraki, Int J Cancer 2012), CXCR7 (Maichi, Pathol Int 2012), Ptgfr (Akiyama , Pathol Int 2013), Lox (Osawa, Brit J Cancer 2013) \u306b\u3064\u3044\u3066\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\uff0e\u73fe\u5728\uff0c\u305d\u306e\u4ed6\u65b0\u898f\u5206\u5b50\u306b\u3064\u3044\u3066\u306f\u5b9f\u7528\u5316\u3092\u76ee\u6307\u3057\u3066\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\uff0e\u7279\u306b\uff0c\u85ac\u5b66\u7814\u7a76\u9662\u30fb\u539f\u5cf6\u79c0\u5409\u6559\u6388\u304c\u7387\u3044\u308b\u672a\u6765\u5275\u5264\u7814\u7a76\u5ba4\uff08http:\/\/www.pharm.hokudai.ac.jp\/mirai\/\uff09\u304c\u958b\u767a\u3057\u305fDDS (\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\u30b7\u30b9\u30c6\u30e0\uff1aMEND)\u3092\u7528\u3044\u3066\uff0c\u816b\u760d\u8840\u7ba1\u3092\u6a19\u7684\u3068\u3059\u308b\u6838\u9178\u533b\u85ac\u306e\u5b9f\u7528\u5316\u3092\u76ee\u6307\u3057\u305f\u5171\u540c\u7814\u7a76\u3082\u884c\u3063\u3066\u3044\u307e\u3059 (Sakurai, J Control Release, Kibria, Biomaterials 2013 \u306a\u30699\u7de8\u306e\u5171\u8457\u8ad6\u6587) \uff0e<\/p>\n

      \u3055\u3089\u306b\u816b\u760d\u8840\u7ba1\u5185\u76ae\u30de\u30fc\u30ab\u30fc\u306e\u3046\u3061\u5206\u6ccc\u30bf\u30f3\u30d1\u30af\u306f\u8a3a\u65ad\u85ac\u3068\u3057\u3066\u3082\u5fdc\u7528\u53ef\u80fd\u3067\u3042\u308a\uff0c\u73fe\u5728\u304c\u3093\u60a3\u8005\u3055\u3093\u306e\u8840\u6db2\u3092\u7528\u3044\u3066\u305d\u306e\u6709\u7528\u6027\u3092\u89e3\u6790\u4e2d\u3067\u3059\uff0e<\/p>\n

      \"\"<\/p>\n

      \uff12\uff0e\u816b\u760d\u8840\u7ba1\u5185\u76ae\u306e\u591a\u69d8\u6027\u89e3\u660e<\/h4>\n

      \u304c\u3093\u306e\u6027\u8cea\u306f\uff0c\u304c\u3093\u7d30\u80de\u306e\u907a\u4f1d\u5b50\u7570\u5e38\u306e\u307f\u3067\u6c7a\u5b9a\u3055\u308c\u308b\u306e\u3067\u306f\u306a\u304f\uff0c\u73fe\u5728\u3067\u306f\u304c\u3093\u7d30\u80de\u306e\u304a\u304b\u308c\u305f\u5fae\u5c0f\u74b0\u5883\u3084\u9593\u8cea\u7d30\u80de\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u5f71\u97ff\u306b\u3088\u3063\u3066\u3082\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff0e\u79c1\u305f\u3061\u306f\uff0c\u304c\u3093\u5fae\u5c0f\u74b0\u5883\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u884c\u3044\uff0c\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u7570\u5e38\u6027\u7372\u5f97\u6a5f\u5e8f\u306b\u3064\u3044\u3066\u3082\u89e3\u6790\u3092\u9032\u3081\u3066\u3044\u307e\u3059\uff0e\u7279\u306b\u304c\u3093\u306e\u60aa\u6027\u5ea6\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u6027\u8cea\uff08\u8840\u7ba1\u65b0\u751f\u80fd\u3084\u907a\u4f1d\u5b50\u767a\u73fe\uff0c\u67d3\u8272\u4f53\u7570\u5e38\u306e\u7a0b\u5ea6\uff0c\u85ac\u5264\u8010\u6027\uff09\u306b\u3082\u9055\u3044\u304c\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\uff0c\u304c\u3093\u5fae\u5c0f\u74b0\u5883\u306e\u9055\u3044\u304c\u816b\u760d\u8840\u7ba1\u5185\u76ae\u306b\u591a\u69d8\u6027\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u307e\u3057\u305f (Ohga, Am J\u00a0 Pathol 2012, \u30cf\u30a4\u30e9\u30a4\u30c8\u306b\u9078\u51fa)\uff0e\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u8ee2\u79fb\u80fd\u304c\u9ad8\u3044\u816b\u760d\u3068\u4f4e\u3044\u816b\u760d\u306b\u304a\u3051\u308b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u9055\u3044\u3067\u3057\u305f\u304c\uff0c\u73fe\u5728\uff0c\u304c\u3093\u306e\u6d78\u6f64\u3084\u8ee2\u79fb\u3068\u306e\u95a2\u4fc2\u3084\u304c\u3093\u5e79\u7d30\u80de\u306e\u30cb\u30c3\u30c1\u3092\u5f62\u6210\u3057\u3066\u3044\u308b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\uff0c\u3055\u3089\u306b\u5e79\u7d30\u80de\u6027\u3092\u3082\u3064\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u7279\u6027\u3092\u63a2\u308b\u3053\u3068\u3067\uff0c\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u591a\u69d8\u6027\u306b\u8feb\u308b\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\uff0e\u305d\u306e\u3053\u3068\u306b\u3088\u308a\uff0c\u304c\u3093\u306e\u9032\u5c55\u306b\u4f34\u3046\u8840\u7ba1\u65b0\u751f\uff0c\u3055\u3089\u306b\u5185\u76ae\u7d30\u80de\u306e\u5f62\u8cea\u306e\u5909\u5316\u306a\u3069\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\uff0c\u5c06\u6765\u7684\u306b\u306f\u8840\u7ba1\u65b0\u751f\u306e\u7a0b\u5ea6\u3084\u72b6\u614b\u3092\u628a\u63e1\u3057\u85ac\u5264\u306e\u9078\u629e\uff0c\u60a3\u8005\u306e\u9078\u629e\u3092\u304a\u3053\u306a\u3046\u500b\u5225\u5316\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u7642\u6cd5\u306e\u5b9f\u73fe\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\uff0e<\/p>\n

      \uff13\uff0e\u816b\u760d\u8840\u7ba1\u5185\u76ae\u304c\u7570\u5e38\u6027\u3092\u7372\u5f97\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u6790\uff08\u304c\u3093\u5fae\u5c0f\u74b0\u5883\u306e\u89b3\u70b9\u304b\u3089\uff09<\/h4>\n

      \u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u7570\u5e38\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\uff0c\u73fe\u5728\uff08\uff11\uff09\u304c\u3093\u7d30\u80de\u306e\u8840\u7ba1\u5185\u76ae\u3078\u306e\u8131\u5206\u5316\uff0c\u7570\u5206\u5316\uff0c\u304c\u3093\u7d30\u80de\u3068\u306e\u7d30\u80de\u878d\u5408\uff0c\uff08\uff12\uff09\u304c\u3093\u5fae\u5c0f\u74b0\u5883\u5185\u56e0\u5b50\uff08\u4f4e\u9178\u7d20\u74b0\u5883\uff0c\u304c\u3093\u7d30\u80de\u7531\u6765\u6db2\u6027\u56e0\u5b50)\u306b\u3088\u308b\u3082\u306e\u306a\u3069\u304c\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff0e\uff08\uff11\uff09\u306b\u95a2\u3057\u3066\u306f\u3059\u3067\u306b\u3044\u304f\u3064\u304b\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u304c\uff0c\u672a\u3060\u4e0d\u660e\u306a\u70b9\u304c\u591a\u3044\u72b6\u6cc1\u3067\u3059\uff0e\u79c1\u9054\u306f\uff08\uff12\uff09\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u8996\u91ce\u306b\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\uff0e\u3053\u308c\u307e\u3067\u81ea\u5206\u9054\u306e\u7814\u7a76\u304b\u3089\uff0c\u304c\u3093\u7d30\u80de\u7531\u6765\u6db2\u6027\u56e0\u5b50\u306b\u3088\u308a\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u85ac\u5264\u8010\u6027\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3053\u3068 (Akiyama, Am J Pathol 2012) \u3084\uff0c\u304c\u3093\u7d30\u80de\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u8840\u7ba1\u5185\u76ae\u304c\u53d6\u308a\u8fbc\u3080\u3053\u3068\u304c\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u9ad8\u3044\u8840\u7ba1\u65b0\u751f\u80fd\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068 (Kawamoto, Plos One 2012) \u3092\u5831\u544a\u3057\u3066\u304d\u307e\u3057\u305f\uff0e\u307e\u305f\uff0c\u4f4e\u9178\u7d20\u74b0\u5883\u3082\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306bROS\u3092\u8a98\u5c0e\u3057\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u67d3\u8272\u4f53\u7570\u5e38\u306e\u539f\u56e0\u306b\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3082\u793a\u5506\u3055\u308c\u307e\u3057\u305f (Kondoh, Plos One 2013)\uff0e\u73fe\u5728\u3055\u3089\u306b\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u7570\u5e38\u6027\u7372\u5f97\u306b\u95a2\u308f\u308b\u816b\u760d\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u4e2d\u306emiRNA\u306a\u3069\u306e\u95a2\u4e0e\u306b\u3064\u3044\u3066\u306e\u57fa\u790e\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\uff0e\u307e\u305f\uff0c\u73fe\u5728\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u5c11\u306a\u304f\u3068\u3082\u4e00\u90e8\u306e\u7279\u6027\u306f\u57f9\u990a\u7d4c\u904e\u306b\u304a\u3044\u3066\u3082\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304a\u308a\uff0c\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7279\u7570\u5206\u5b50\u306e\u767a\u73fe\u5236\u5fa1\u306b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u6a5f\u69cb\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u3082\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\uff0e<\/p>\n

      \uff14\uff0e\u304c\u3093\u5e79\u7d30\u80de\uff64\u304c\u3093\u306e\u6d78\u6f64\u8ee2\u79fb\u306b\u304a\u3051\u308b\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306e\u6a5f\u80fd\u89e3\u6790<\/h4>\n

      \u816b\u760d\u8840\u7ba1\u306f\uff0c\u304c\u3093\u7d44\u7e54\u3092\u990a\u3046\u3070\u304b\u308a\u3067\u306f\u306a\u304f\uff0c\u304c\u3093\u5e79\u7d30\u80de\u306e\u30cb\u30c3\u30c1\uff08\u4f4f\u307f\u304b\uff09\u3092\u5f62\u6210\u3057\u3066\u3044\u308b\u3053\u3068\u3084\uff0c\u304c\u3093\u306e\u8ee2\u79fb\u306b\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u3066\u3044\u307e\u3059\uff0e\u304c\u3093\u5fae\u5c0f\u74b0\u5883\u5185\u3067\u7570\u5e38\u6027\u3092\u7372\u5f97\u3057\u305f\u816b\u760d\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u304c\uff0c\u304c\u3093\u306e\u6d78\u6f64\u8ee2\u79fb\u3084\u304c\u3093\u5e79\u7d30\u80de\u306e\u30cb\u30c3\u30c1\u5f62\u6210\u306b\u95a2\u4e0e\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3057\u3066\u3082\u89e3\u6790\u3092\u9032\u3081\u3066\u3044\u307e\u3059\uff0e<\/p>\n

      \u3055\u3089\u306b\uff0c\u8840\u7ba1\u65b0\u751f\u30fb\u963b\u5bb3\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u304f\u904e\u7a0b\u3067\u898b\u3064\u3051\u51fa\u3057\u3064\u3064\u3042\u308b\uff0c\u8840\u7ba1\u65b0\u751f\u95a2\u9023\u5206\u5b50\u306b\u3082\u7740\u76ee\u3057\u3066\u3044\u307e\u3059\uff0e\u5c06\u6765\uff0c\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u306e\u8840\u7ba1\u518d\u751f\u30fb\u7d44\u7e54\u518d\u751f\u306b\u3082\u5fdc\u7528\u304c\u671f\u5f85\u3055\u308c\u308b\u3068\u601d\u308f\u308c\u307e\u3059\uff0e<\/p>\n","protected":false},"excerpt":{"rendered":"

      \u75c5\u7406\u5b66\u306f\u75c5\u6c17\u306e\u539f\u56e0\u3068\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3057\u305d\u306e\u672c\u614b\u3092\u8ffd\u7a76\u3059\u308b\u5b66\u554f\u3067\u3059\uff0e\u57fa\u790e\u533b\u5b66\u306b\u5c5e\u3057\u307e\u3059\u304c\uff0c\u81e8\u5e8a\u3068\u306e\u67b6\u3051\u6a4b\u306e\u5f79\u5272\u3082\u62c5\u3063\u3066\u3044\u307e\u3059\uff0e\u75c5\u7406\u5b66\u306f\u9577\u5e74\u306b\u308f\u305f\u308a\u4e3b\u306b\u5f62\u614b\u5b66\u7684\u306a\u624b\u6cd5\u3092\u7528\u3044\u305f\u7814\u7a76\u306b\u3088\u308a\u767a\u5c55\u3057\u3066\u304d\u307e\u3057\u305f\u304c\uff0c\u73fe\u5728\uff0c\u751f\u5316\u5b66\uff0c\u5206\u5b50\u751f\u7269\u5b66\uff0c\u7d30\u80de\u751f\u7269\u5b66\u306a\u3069\u69d8\u3005\u306a\u624b\u6cd5\u3092\u53d6\u308a\u5165\u308c\u3066\u75be\u60a3\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e\u3092\u76ee\u6307\u3059\u3053\u3068\u304c\u4e00\u822c\u7684\u306b\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\uff0e \u5f53\u6559\u5ba4\u3067\u306f\uff0c\u65e5\u3005\u306e\u75c5\u7406\u8a3a\u65ad\u306b\u52a0\u3048\uff0c\u4e3b\u306b\u304c\u3093\u306e\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u3044\u307e\u3059\uff0e\u73fe\u5728\u304c\u3093…\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-16","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.den.hokudai.ac.jp\/vascular-biol-pathol\/wp-json\/wp\/v2\/pages\/16","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.den.hokudai.ac.jp\/vascular-biol-pathol\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.den.hokudai.ac.jp\/vascular-biol-pathol\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.den.hokudai.ac.jp\/vascular-biol-pathol\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.den.hokudai.ac.jp\/vascular-biol-pathol\/wp-json\/wp\/v2\/comments?post=16"}],"version-history":[{"count":9,"href":"https:\/\/www.den.hokudai.ac.jp\/vascular-biol-pathol\/wp-json\/wp\/v2\/pages\/16\/revisions"}],"predecessor-version":[{"id":116,"href":"https:\/\/www.den.hokudai.ac.jp\/vascular-biol-pathol\/wp-json\/wp\/v2\/pages\/16\/revisions\/116"}],"wp:attachment":[{"href":"https:\/\/www.den.hokudai.ac.jp\/vascular-biol-pathol\/wp-json\/wp\/v2\/media?parent=16"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}