{"id":256,"date":"2024-06-10T16:02:58","date_gmt":"2024-06-10T07:02:58","guid":{"rendered":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/?page_id=256"},"modified":"2024-06-11T16:13:55","modified_gmt":"2024-06-11T07:13:55","slug":"achievements-2005","status":"publish","type":"page","link":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/achievements-2005\/","title":{"rendered":"2005"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u539f\u8457\u8ad6\u6587<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16299289?dopt=AbstractPlus\">Tada H, Aiba S, Shibata K, Ohteki T, Takada H. Synergistic effect of nod1 and nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells.<em>&nbsp;Infect. Immun.<\/em>&nbsp;73: 7967-76, 2005.&nbsp;<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16113324?dopt=AbstractPlus\">Cole BC, Mu H-H, Pennock ND, Hasebe A, Chan FV, Washburn LR, Peltier M. Isolation and Partial Purification of Macrophage- and Dendritic Cell-Activating Components from&nbsp;<em>Mycoplasma arthritidis<\/em>: Association with Organism Virulence and Involvement with Toll-Like Receptor 2.&nbsp;<em>Infect.Immun.&nbsp;<\/em>73: 6039-6047, 2005.<\/a><\/li>\n\n\n\n<li>Kiura K, Sato Y, Yasuda M, Fugetsu B, Watari F, Tohji K, S.hibata K. Activation of Human Monocytes and Mouse Splenocytes by Single-Walled Carbon Nanotubes.&nbsp;<em>J. Biomed. Nanotechnol.<\/em>&nbsp;1: 359-364. 2005.<\/li>\n\n\n\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16098218?dopt=AbstractPlus\">Into T, Shibata K. Apoptosis signal-regulating kinase 1 (ASK1)-mediated sustained p38 MAPK activation regulates mycoplasmal lipoprotein- and staphylococcal peptidoglycan-triggered Toll-like receptor 2 signaling pathways.&nbsp;<em>Cell. Microbiol.&nbsp;<\/em>7: 1305-1317. 2005.&nbsp;<\/a><\/li>\n\n\n\n<li>Sato Y, Yokoyama A, Shibata K, Akimoto Y, Ogino S, Nodasaka Y, Kohgo T, Tamura K, Akasaka T, Uo M, Motomiya K, Jeyadevan B, Ishiguro M, Hatakeyama R, Watari F, Tohji K. Influence of Length on Cytotoxicity of Multi-Walled Carbon Nanotubes against Human Acute Monocytic Leukemia Cell Line THP-1 in Vitro and Subcutaneous Tissue of Rats in Vivo.&nbsp;<em>Molecular BioSystems<\/em>&nbsp;1: 142-145. 2005.<\/li>\n\n\n\n<li>Sato Y, Shibata K, Kataoka H, Fugetsu B, Yokoyama A, Tamura K, Akasaka T, Uo M, Motomiya K, Jeyadevan B, Hatakeyama R., Watari F. Tohji K. Strict preparation and evaluation of water-soluble hat-stacked carbon nanofibers for biomedical application and their high biocompatibility: Influence of nanofiber-surface functional groups on cytotoxicity.<em>&nbsp;Molecular BioSystems&nbsp;<\/em>1: 176-182. 2005.<\/li>\n\n\n\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15617523?dopt=AbstractPlus\">Uehara A, Yang S, Fujimoto Y, Fukase K, Kusumoto S, Shibata K, Sugawara S, Takada H. Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combinatin with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD-2 and NOD-1 dependent manner, respectively, in human monocytic cells in culture.<em>&nbsp;Cell. Microbiol.<\/em>&nbsp;7: 53-61. 2005.&nbsp;<\/a><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u7dcf\u8aac\u30fb\u89e3\u8aac\u30fb\u8a55\u8ad6<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. \u7279\u96c6\u2160 TLR\u30b7\u30b0\u30ca\u30eb\u3068\u305d\u306e\u5236\u5fa1\uff0eTLR2\u306e\u69cb\u9020\u3068\u30ea\u30dd\u86cb\u767d\u8cea\u306e\u8a8d\u8b58.&nbsp;<em>\u81e8\u5e8a\u514d\u75ab<\/em>. 44: 113-119. 2005.<\/li>\n\n\n\n<li>\u4e0a\u539f\u4e9c\u5e0c\u5b50\u3001\u85e4\u672c\u3086\u304b\u308a\u3001\u6df1\u702c\u6d69\u4e00\u3001\u6960\u672c\u6b63\u4e00\u3001\u67f4\u7530\u5065\u4e00\u90ce\u3001\u83c5\u539f\u4fca\u4e8c\u3001\u9ad8\u7530\u6625\u6bd4\u53e4\uff0e\u81ea\u7136\u514d\u75ab\u7cfb\u306e\u7d30\u83cc\u8a8d\u8b58\u306b\u304a\u3051\u308bNOD\u7cfb\u3068TLR\u7cfb\u523a\u6fc0\u306e\u76f8\u4e57\u4f5c\u7528\uff0e<em>\u65e5\u672c\u30a8\u30f3\u30c9\u30c8\u30ad \u30b7\u30f3\u7814\u7a76<\/em>\u30008\uff1a33-39\uff0e<\/li>\n\n\n\n<li>\u5f15\u982d\u3000\u6bc5\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce\uff1b\u30de\u30a4\u30b3\u30d7\u30e9\u30ba\u30de\u306e\u7d30\u80de\u819c\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u8a98\u5c0e\u3059\u308bToll-like receptor2\u3092\u4ecb\u3057\u305f\u30c7\u30b9\u30b7\u30b0\u30ca\u30eb\uff0e&nbsp;<em>\u65e5\u672c\u30a8\u30f3\u30c9\u30c8\u30ad\u30b7\u30f3\u7814\u7a76<\/em>\u30008\uff1a40-47\uff0e<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u67f4\u7530\u5065\u4e00\u90ce. Toll-like receptor 2\u306b\u3088\u308b\u30ea\u30ac\u30f3\u30c9\u8a8d\u8b58\u6a5f\u69cb\u306b\u3064\u3044\u3066\uff0e\u7b2c32\u56de\u65e5\u672c\u30de\u30a4\u30b3\u30d7\u30e9\u30ba\u30de\u5b66\u4f1a \u300c\u30de\u30a4\u30b3\u30d7\u30e9\u30ba\u30de\u304a\u3088\u3073\u30d5\u30a1\u30a4\u30c8\u30d7\u30e9\u30ba\u30de\u7814\u7a76\u306e\u6700\u5148\u7aef\u300d \uff08\u4e45\u7559\u7c73\uff09.2005.<\/li>\n\n\n\n<li>\u6728\u6d66\u3000\u548c\u4eba\u3001\u4e95\u4e0a\u3000\u8fb2\u592b\u7537\u3001\u5b89\u7530\u3000\u5143\u662d\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce\uff0e\u5fae\u751f\u7269\u7531\u6765\u30ea\u30dd\u30da\u30d7\u30c1\u30c9\u306e\u30a2\u30b8\u30e5\u30d0\u30f3\u30c8\u6d3b\u6027. \u7b2c73\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\uff08\u672d\u5e4c\uff09. \u7b2c73\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\u6284\u9332\u96c6. 2005.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u5b66\u4f1a\u767a\u8868<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6728\u6d66\u3000\u548c\u4eba\u3001\u5f15\u982d\u3000\u6bc5\u3001\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u5b89\u7530\u3000\u5143\u662d\u3001\u4e95\u4e0a\u3000\u8fb2\u592b\u7537\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce.\u3000TLR2\u3092\u4ecb\u3057\u305f\u9aa8\u9ac4\u7531\u6765\u306e\u6a39\u72b6\u7d30\u80de\u306e\u6d3b\u6027\u5316.\u3000\u7b2c78\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u7dcf\u4f1a\uff08\u6771\u4eac\uff09.\u3000\u65e5\u672c\u7d30\u83cc\u5b66\u96d1\u8a8c. 60(1):146. 2005.<\/li>\n\n\n\n<li>\u83ca\u6c60\u3000\u88d5\u5b50\u3001\u83ca\u6c60\u3000\u7950\u4e8c.\u3000<em>E.coli<\/em>&nbsp;\u6dfb\u52a0\u306b\u3088\u308b\u5168\u8840\u6d41\u52d5\u6027\u306e\u5909\u5316.\u3000\u7b2c78\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u7dcf\u4f1a\uff08\u6771\u4eac\uff09.\u3000\u65e5\u672c\u7d30\u83cc\u5b66\u96d1\u8a8c. 60(1):139. 2005.<\/li>\n\n\n\n<li>\u5f15\u982d\u3000\u6bc5\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce.\u3000ASK1\u306fTLR2\u4e0b\u6d41\u3067\u8ee2\u5199\u56e0\u5b50AP-1\u306a\u3089\u3073\u306bNF-kB\u306e\u6d3b\u6027\u5316\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u5236\u5fa1\u3059\u308b.\u3000\u7b2c78\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u7dcf\u4f1a\uff08\u6771\u4eac\uff09.\u3000\u65e5\u672c\u7d30\u83cc\u5b66\u96d1\u8a8c. 60(1):140. 2005.<\/li>\n\n\n\n<li>\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u5b89\u7530\u3000\u5143\u662d\u3001\u5f15\u982d\u3000\u6bc5\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce.\u3000\u30ea\u30ac\u30f3\u30c9\u8a8d\u8b58\u306b\u304a\u3051\u308bToll-like receptor 2 \u7d50\u5408\u7cd6\u9396\u306e\u5f79\u5272.\u3000\u7b2c78\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u7dcf\u4f1a\uff08\u6771\u4eac\uff09.\u3000\u65e5\u672c\u7d30\u83cc\u5b66\u96d1\u8a8c. 60(1):144. 2005.<\/li>\n\n\n\n<li>\u524d\u3000\u591a\u539a\u3001\u5b89\u7530\u3000\u5143\u662d\u3001\u6238\u585a\u3000\u9756\u5247\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. \u30de\u30a4\u30b3\u30d7\u30e9\u30ba\u30de\u7531\u6765\u30ea\u30dd\u30da\u30d7\u30c1\u30c9\u306e\u8caa\u98df\u4fc3\u9032\u6d3b\u6027. \u7b2c73\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\uff08\u672d\u5e4c\uff09. \u7b2c73\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\u6284\u9332\u96c6. 2005.<\/li>\n\n\n\n<li>\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u5b89\u7530\u3000\u5143\u662d\u3001\u4f0a\u5f93\u3000\u5149\u6d0b\u3001\u6728\u6d66\u3000\u548c\u4eba\u3001\u4e2d\u7530\u3000\u8cb4\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. Toll-like receptor 2\u306e\u30ea\u30ac\u30f3\u30c9\u8a8d\u8b58\u306b\u304a\u3051\u308b\u7d50\u5408\u7cd6\u9396\u306e\u95a2\u4e0e. \u7b2c73\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\uff08\u672d\u5e4c\uff09. \u7b2c73\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\u6284\u9332\u96c6. 2005.<\/li>\n\n\n\n<li>\u524d\u3000\u591a\u539a\u3001\u5b89\u7530\u3000\u5143\u662d\u3001\u6238\u585a\u3000\u9756\u5247\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. \u30de\u30a4\u30b3\u30d7\u30e9\u30ba\u30de\u7531\u6765\u30ea\u30dd\u30da\u30d7\u30c1\u30c9\u306e\u8caa\u98df\u4fc3\u9032\u6d3b\u6027. \u7b2c47\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\uff08\u4ed9\u53f0\uff09. \u7b2c47\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\u6284\u9332\u96c6. 47(5): 93. 2005.<\/li>\n\n\n\n<li>\u6728\u6d66\u3000\u548c\u4eba\u3001\u4e95\u4e0a\u3000\u8fb2\u592b\u7537\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. \u30b8\u30a2\u30b7\u30eb\u30ea\u30dd\u30da\u30d7\u30c1\u30c9\u306b\u3088\u308b\u6a39\u72b6\u7d30\u80de\u306e\u6d3b\u6027\u5316. \u7b2c47\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\uff08\u4ed9\u53f0\uff09. \u7b2c47\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\u6284\u9332\u96c6. 47(5): 128. 2005.<\/li>\n\n\n\n<li>\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u5b89\u7530\u3000\u5143\u662d\u3001\u4f0a\u5f93\u3000\u5149\u6d0b\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. \u7a2e\u3005\u306e\u30ea\u30ac\u30f3\u30c9\u8a8d\u8b58\u306b\u304a\u3051\u308bToll-like receptor 2 \u7d50\u5408\u7cd6\u9396\u306e\u5f79\u5272. \u7b2c47\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\uff08\u4ed9\u53f0\uff09. \u7b2c47\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\u6284\u9332\u96c6. 47(5): 144. 2005.<\/li>\n\n\n\n<li>Nakata T,Yasuda M,Kataoka H, Iyori M, Kiura K, Shibata K. TLR1 is indispensable for CD14-induced enhancement of the recognition of microbial lipopeptides by TLR2.\u65e5\u672c\u514d\u75ab\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u96c6\u4f1a\uff08\u6a2a\u6d5c\uff09. \u65e5\u672c\u514d\u75ab\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u96c6\u4f1a\u8a18\u9332. 35:42. 2005.<\/li>\n\n\n\n<li>\u5b89\u7530\u3000\u5143\u662d\u3001\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u4f0a\u5f93\u3000\u5149\u6d0b\u3001\u4e2d\u7530\u3000\u8cb4\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. \u30d2\u30c8\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b9E1A\u306f\u7d30\u83cc\u306b\u5bfe\u3059\u308b\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u3092\u6291\u5236\u3059\u308b. \u65e5\u672c\u514d\u75ab\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u96c6\u4f1a\uff08\u6a2a\u6d5c\uff09. \u65e5\u672c\u514d\u75ab\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u96c6\u4f1a\u8a18\u9332. 35:43. 2005.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u8457\u66f8<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u67f4\u7530\u3000\u5065\u4e00\u90ce.\u3000\u53e3\u8154\u5fae\u751f\u7269\u5b66\u30fb\u514d\u75ab\u5b66\u3000\u7b2c2\u7248\u3000\u6d5c\u7530\u3000\u8302\u5e78\u3000\u7de8\uff0e\u30de\u30a4\u30b3\u30d7\u30e9\u30ba\u30de \u3068\u611f\u67d3\u75c7 (p130-p133)\u3001\u30af\u30e9\u30df\u30b8\u30a2\u3068\u611f\u67d3\u75c7 (p134-p135)\u3001\u30ea\u30b1\u30c3\u30c1\u30a2\u3068\u611f\u67d3\u75c7 (p136-p138)\u3001\u533b\u6b6f\u85ac\u51fa\u7248\u30012005<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u5b66\u4f1a\u4e3b\u50ac<\/h2>\n\n\n\n<p>\u7b2c73\u56de\u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a<br>\u3000\u3000\u4f1a\u9577\uff1a\u67f4\u7530\u5065\u4e00\u90ce<br>\u3000\u3000\u4f1a\u671f\uff1a\u5e73\u621017\u5e749\u670817\u65e5\uff08\u571f\uff09<br>\u3000\u3000\u4f1a\u5834\uff1a\u5317\u6d77\u9053\u5927\u5b66\u5b66\u8853\u4ea4\u6d41\u4f1a\u9928\u5c0f\u8b1b\u5802<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u539f\u8457\u8ad6\u6587 \u7dcf\u8aac\u30fb\u89e3\u8aac\u30fb\u8a55\u8ad6 \u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u5b66\u4f1a\u767a\u8868 \u8457\u66f8 \u5b66\u4f1a\u4e3b\u50ac \u7b2c73\u56de\u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\u3000\u3000\u4f1a\u9577\uff1a\u67f4\u7530\u5065\u4e00\u90ce\u3000\u3000\u4f1a\u671f\uff1a\u5e73\u621017\u5e749\u670817\u65e5\uff08\u571f\uff09\u3000\u3000\u4f1a\u5834\uff1a\u5317\u6d77\u9053\u5927\u5b66\u5b66\u8853\u4ea4\u6d41\u4f1a\u9928\u5c0f\u8b1b\u5802<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"vkexunit_cta_each_option":"","footnotes":""},"class_list":["post-256","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/pages\/256","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/comments?post=256"}],"version-history":[{"count":3,"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/pages\/256\/revisions"}],"predecessor-version":[{"id":452,"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/pages\/256\/revisions\/452"}],"wp:attachment":[{"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/media?parent=256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}