{"id":249,"date":"2024-06-10T15:57:59","date_gmt":"2024-06-10T06:57:59","guid":{"rendered":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/?page_id=249"},"modified":"2024-06-10T15:58:18","modified_gmt":"2024-06-10T06:58:18","slug":"achievements-2004","status":"publish","type":"page","link":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/achievements-2004\/","title":{"rendered":"2004"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u539f\u8457\u8ad6\u6587<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hamahira S, Nakamura M, Khan MH, Choudhury AR., Shibata K, Yasuda M. Comprehensive detection of human papilomavirus in buccal cancer collected in Bangladesh.<em>\u00a0Dentistry in Japan<\/em>\u00a041:19-24.2005<\/li>\n\n\n\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15353553?dopt=Abstract\">Sato N, Takahashi N, Suda K, Nakamura M, Yamaki M, Ninomiya T, Kobayashi Y, Takada H, Shibata K, Yamamoto M, Takeda K, Akira S, Noguchi T, Udagawa N. MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha.\u00a0<em>J Exp Med<\/em>\u00a0200: 601-611. 2004.\u00a0<\/a><\/li>\n\n\n\n<li>Sato Y, Akimoto Y, Jeyadevan B, Motomiya K, Hatakeyama, R, Tamura K, Akasaka T, Uo A, Yokoyama A, Shibata K, Watari F, Tohji K. Size separation of carbon nanotubes for biomedical applications.<em>\u00a0SPIE<\/em>\u00a05593: 13-17, 2004.<\/li>\n\n\n\n<li>Kuroiwa M, Nakamura J, Ogawa T, Shibata K, Kawasaki T. Comparison of biological activities of mycoplasmal diacylated lipopeptide with those of\u00a0<em>Escherichia coli\u00a0<\/em>lipopolysaccharide and its active entity, lipid A.\u00a0<em>Hokkaido J. Dent. Sci.,<\/em>\u00a025: 270-280. 2004.<\/li>\n\n\n\n<li>Okada K, Yasuda M, Shibata K, Inoue N. Mitochondrial Apoptotic Signaling Pathway Induced by\u00a0<em>Mycoplasma fermentans<\/em>\u00a0Lipoproteins and Its Suppression by Anti-apoptosis Bcl-xL or Adenovirus E1B 19K.\u00a0<em>Hokkaido J. Dent. Sci.,<\/em>\u00a025: 258-269. 2004.<\/li>\n\n\n\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14977934?dopt=Abstract\">Hasebe A, Yoshimura A, Into T, Kataoka H, Tanaka S, Arakawa S, Ishikura H, Golenbock DT, Sugaya T, Tsuchida N, Kawanami M, Hara Y, Shibata K. Biological activities of\u00a0<em>Bacteroides forsythus<\/em>\u00a0lipoproteins and their possible pathological roles in periodontal disease.\u00a0\u00a0<em>Infect Immun<\/em>\u00a072: 1318-1325. 2004.\u00a0<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14977973?dopt=Abstract\">Okusawa T, Fujita M, Nakamura J, Into T, Yasuda M, Yoshimura A, Hara Y, Hasebe A, Golenbock DT, Morita M, Kuroki Y, Ogawa T, Shibata K. Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by Toll-like receptors 2 and 6.\u00a0<em>Infect Immun<\/em>\u00a072: 1657-1665. 2004.<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14706104?dopt=Abstract\">Into T, Kiura K, Yasuda M, Kataoka H, Inoue N, Hasebe A, Takeda K, Akira S, Shibata K. Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of\u00a0<em>Mycoplasma fermentans<\/em>\u00a0induces apoptotic cell death after NF-kappa B activation.\u00a0<em>Cell Microbiol\u3000<\/em>6: 187-199. 2004.<\/a>\u3000<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u7dcf\u8aac\u30fb\u89e3\u8aac\u30fb\u8a55\u8ad6\u7b49<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Into T, Shibata K. Possible roles of Toll-like receptor 2\/6 and extracellular ATP on mycoplasmal membrane lipoprotein-induced cell activation and death.\u00a0<em>J Oral Biosci<\/em>\u00a046: 278-288. 2004.<\/li>\n\n\n\n<li>Shibata K, Fujita M, Morita M. Structure-function relationship of mycoplasmal lipoproteins\/lipopeptides and their recognition by Toll-like receptor 2.\u00a0<em>J Oral Biosci<\/em>\u00a046: 203-220. 2004.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u7279\u5225\u8b1b\u6f14\u30fb\u8a18\u5ff5\u8b1b\u6f14<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Shibata K. Chemistry, and of other microbial targets of innate immunity: Structure-activity relationships of bacterial lipopeptides with TLR2\/heterodimers. 8th International Conference of the International Endotoxin Society (Kyoto). 2004.<\/li>\n\n\n\n<li>\u67f4\u7530\u3000\u5065\u4e00\u90ce. Toll-like receptor 2\u306b\u3088\u308b\u30ea\u30ac\u30f3\u30c9\u8a8d\u8b58\u6a5f\u69cb\u306b\u3064\u3044\u3066. \u7b2c72\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\uff08\u672d\u5e4c\uff09. \u7b2c72\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\u6284\u9332\u96c6. 2004.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u67f4\u7530\u3000\u5065\u4e00\u90ce. \u6b6f\u5468\u75c5\u539f\u83cc\u306eEBM:\u00a0<em>Bacteroides forsythus<\/em>\u7531\u6765\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u751f\u7269\u6d3b\u6027. \u7b2c47\u56de \u65e5\u672c\u6b6f\u5468\u75c5\u5b66\u4f1a\uff08\u4ed9\u53f0\uff09. 2004.<\/li>\n\n\n\n<li>\u5f15\u982d\u3000\u6bc5. \u5fae\u751f\u7269\u7531\u6765\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u308a\u8a98\u5c0e\u3055\u308c\u308bToll-like receptor 2\u3092\u4ecb\u3057\u305f\u7d30\u80de\u5fdc\u7b54\u306b\u3064\u3044\u3066. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\uff08\u5e83\u5cf6\uff09. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\u6284\u9332\u96c6. 46(5): 23. 2004.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u56fd\u969b\u5b66\u4f1a\u767a\u8868<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Shibata K, Fujita M, Morita M, Into T, Yasuda M, Hamahira M. : Involvement of leucine residues at positions 107, 112 and 115 in a leucine-rich repeat motif of human Toll-like receptor 2 in the recognition of diacylated lipoproteins and\u00a0<em>Staphylococcus aueus<\/em>\u00a0peptidoglycans. Toll meeting 2004 (Taormina, Italy). 2004.<\/li>\n\n\n\n<li>Into T, Kiura K, Yasuda M, Kataoka T, and Shibata K. Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of\u00a0<em>Mycoplasma fermentans<\/em>\u00a0induces apoptotic cell death after NF-kappa B activation. Toll meeting 2004 (Taormina, Italy). 2004.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u56fd\u5916\u5b66\u4f1a\u767a\u8868<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hasebe A, Pennock ND, Mu HH, Cole BC. Purification of a cell surface bioactive lipoprotein(s) from\u00a0<em>Mycoplasma arthritidis<\/em>\u00a0that utilizes TLR2. American Society for Microbiology 104th General Meeting, May 23-27, 2004, New Orleans, Louisiana. 104th General Meeting Abstracts: 144\/G<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">\u5b66\u4f1a\u767a\u8868<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u5f15\u982d\u3000\u6bc5\u3001\u85e4\u7530\u3000\u771f\u7406\u3001\u6728\u6d66\u3000\u548c\u4eba\u3001\u4e2d\u7530\u3000\u8cb4\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. Toll-like receptor 2\u306b\u5b58\u5728\u3059\u308b\u30ed\u30a4\u30b7\u30f3\u30ea\u30c3\u30c1\u30ea\u30d4\u30fc\u30c8\u306e\u30ea\u30ac\u30f3\u30c9\u8a8d\u8b58\u306b\u304a\u3051\u308b\u5f79\u5272. \u65e5\u672c\u514d\u75ab\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u96c6\u4f1a\uff08\u672d\u5e4c\uff09. \u65e5\u672c\u514d\u75ab\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u96c6\u4f1a\u8a18\u9332. 34:287. 2004.<\/li>\n\n\n\n<li>\u67f4\u7530\u3000\u5065\u4e00\u90ce\u3001\u5f15\u982d\u3000\u6bc5. \u30de\u30a4\u30b3\u30d7\u30e9\u30ba\u30de\u7d30\u80de\u819c\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306fToll-like receptor( TLR )2\u306a\u3089\u3073\u306bTLR6\u3092\u4ecb\u3057\u3066MyD88\u3068FADD\u306b\u4f9d\u5b58\u7684\u306a\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3059\u308b. \u7b2c10\u56de \u65e5\u672c\u30a8\u30f3\u30c9\u30c9\u30ad\u30b7\u30f3\u7814\u7a76\u4f1a\uff08\u4eac\u90fd\uff09. 2004.<\/li>\n\n\n\n<li>\u6ff1\u5e73\u3000\u9808\u7f8e\u5b50. \u30d2\u30c8\u30d1\u30d4\u30ed\u30fc\u30de\u30a6\u30a4\u30eb\u30b9\u306e\u7db2\u7f85\u7684\u691c\u51fa. \u5e73\u621016\u5e74\u5ea6\u5317\u6d77\u9053\u6b6f\u5b66\u4f1a \u79cb\u5b63\u5b66\u8853\u5927\u4f1a\uff08\u672d\u5e4c\uff09. \u5e73\u621016\u5e74\u5ea6\u5317\u6d77\u9053\u6b6f\u5b66\u4f1a \u79cb\u5b63\u5b66\u8853\u5927\u4f1a\u30d7\u30ed\u30b0\u30e9\u30e0\u8b1b\u6f14\u5185\u5bb9\u6284\u9332. 2004.<\/li>\n\n\n\n<li>\u85e4\u7530\u3000\u771f\u7406. Toll-like receptor 2\u306b\u3088\u308b\u30b8\u30a2\u30b7\u30eb\u30ea\u30dd\u30da\u30d7\u30c1\u30c9\u306e\u8a8d\u8b58\u6a5f\u69cb\u306b\u3064\u3044\u3066. \u5e73\u621016\u5e74\u5ea6\u5317\u6d77\u9053\u6b6f\u5b66\u4f1a \u79cb\u5b63\u5b66\u8853\u5927\u4f1a\uff08\u672d\u5e4c\uff09. \u5e73\u621016\u5e74\u5ea6\u5317\u6d77\u9053\u6b6f\u5b66\u4f1a \u79cb\u5b63\u5b66\u8853\u5927\u4f1a\u30d7\u30ed\u30b0\u30e9\u30e0\u8b1b\u6f14\u5185\u5bb9\u6284\u9332. 2004.<\/li>\n\n\n\n<li>\u5ca1\u7530\u3000\u548c\u9686.\u00a0<em>Mycoplasma fermentans<\/em>\u7531\u6765\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3088\u308b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u8a98\u5c0e\u30e1\u30ab\u30cb\u30ba\u30e0. \u5e73\u621016\u5e74\u5ea6\u5317\u6d77\u9053\u6b6f\u5b66\u4f1a \u79cb\u5b63\u5b66\u8853\u5927\u4f1a\uff08\u672d\u5e4c\uff09. \u5e73\u621016\u5e74\u5ea6\u5317\u6d77\u9053\u6b6f\u5b66\u4f1a \u79cb\u5b63\u5b66\u8853\u5927\u4f1a\u30d7\u30ed\u30b0\u30e9\u30e0\u8b1b\u6f14\u5185\u5bb9\u6284\u9332. 2004.<\/li>\n\n\n\n<li>\u9ed2\u5ca9\u3000\u7406\u66a2. \u5408\u6210\u30ea\u30dd\u30da\u30d7\u30c1\u30c9\u3001\u5927\u8178\u83cc\u30ea\u30dd\u591a\u7cd6\u4f53\u306a\u3089\u3073\u306b\u5408\u6210\u30ea\u30d4\u30c9A\u306b\u3088\u308b\u6b6f\u8089\u7dda\u7dad\u82bd\u7d30\u80de\u304a\u3088\u3073\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u6d3b\u6027\u5316\u80fd\u306e\u6bd4\u8f03. \u5e73\u621016\u5e74\u5ea6\u5317\u6d77\u9053\u6b6f\u5b66\u4f1a \u79cb\u5b63\u5b66\u8853\u5927\u4f1a\uff08\u672d\u5e4c\uff09. \u5e73\u621016\u5e74\u5ea6\u5317\u6d77\u9053\u6b6f\u5b66\u4f1a \u79cb\u5b63\u5b66\u8853\u5927\u4f1a\u30d7\u30ed\u30b0\u30e9\u30e0\u8b1b\u6f14\u5185\u5bb9\u6284\u9332. 2004.<\/li>\n\n\n\n<li>\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u5f15\u982d\u3000\u6bc5\u3001\u85e4\u7530\u3000\u771f\u7406\u3001\u6728\u6d66\u3000\u548c\u4eba\u3001\u4e2d\u7530\u3000\u8cb4\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. Toll-like receptor 2\u306e\u30ea\u30ac\u30f3\u30c9\u8a8d\u8b58\u306b\u304a\u3051\u308b\u30ed\u30a4\u30b7\u30f3\u30ea\u30c3\u30c1\u30ea\u30d4\u30fc\u30c8\u306e\u95a2\u4e0e\u306b\u3064\u3044\u3066. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\uff08\u5e83\u5cf6\uff09. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\u6284\u9332\u96c6. 46(5): 84. 2004.<\/li>\n\n\n\n<li>\u524d\u3000\u591a\u539a\u3001\u6728\u6d66\u3000\u548c\u4eba\u3001\u5b89\u7530\u3000\u5143\u662d\u3001\u85e4\u7530\u3000\u771f\u7406\u3001\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u5f15\u982d\u3000\u6bc5\u3001\u6238\u585a\u3000\u9756\u5247\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. \u7d30\u83cc\u8caa\u98df\u306b\u304a\u3051\u308bToll-like receptor 2. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\uff08\u5e83\u5cf6\uff09. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\u6284\u9332\u96c6. 46(5): 84. 2004.<\/li>\n\n\n\n<li>\u85e4\u7530\u3000\u771f\u7406\u3001\u5f15\u982d\u3000\u6bc5\u3001\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u5b89\u7530\u3000\u5143\u662d\u3001\u68ee\u7530\u3000\u5b66\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. Toll-like receptor 2\u306b\u3088\u308b\u30ea\u30dd\u30da\u30d7\u30c1\u30c9\u306e\u8a8d\u8b58\u306b\u304a\u3051\u308bTLR1\u306a\u3089\u3073\u306bCD14\u306e\u95a2\u4e0e\u306b\u3064\u3044\u3066. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\uff08\u5e83\u5cf6\uff09. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\u6284\u9332\u96c6. 46(5): 84. 2004.<\/li>\n\n\n\n<li>\u6ff1\u5e73\u3000\u9808\u7f8e\u5b50\u3001\u5b89\u7530\u3000\u5143\u662d\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. DNA\u30a2\u30ec\u30a4\u6cd5\u3092\u7528\u3044\u305f\u30d2\u30c8\u30d1\u30d4\u30ed\u30fc\u30de\u30a6\u30a4\u30eb\u30b9\u306e\u7db2\u7f85\u7684\u691c\u51fa. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\uff08\u5e83\u5cf6\uff09. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\u6284\u9332\u96c6. 46(5): 23. 2004.<\/li>\n\n\n\n<li>\u4e2d\u7530\u3000\u8cb4\u3001\u5f15\u982d\u3000\u6bc5\u3001\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u4f50\u91ce\u3000\u82f1\u5f66\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. CD14\u6297\u539f\u306b\u3088\u308bTLR3\u306e\u30ea\u30ac\u30f3\u30c9\u8a8d\u8b58\u306e\u5897\u5f37\u52b9\u679c. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\uff08\u5e83\u5cf6\uff09. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\u6284\u9332\u96c6. 46(5): 118. 2004.<\/li>\n\n\n\n<li>\u9ed2\u5ca9\u3000\u7406\u66a2\u3001\u5c0f\u5ddd\u3000\u77e5\u5f66\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. \u5408\u6210\u30ea\u30dd\u30da\u30d7\u30c1\u30c9\u3068\u5408\u6210lipid A\u306b\u3088\u308b\u6b6f\u8089\u7dda\u7dad\u82bd\u7d30\u80de\u304a\u3088\u3073\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u6d3b\u6027\u5316. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\uff08\u5e83\u5cf6\uff09. \u7b2c46\u56de \u6b6f\u79d1\u57fa\u790e\u533b\u5b66\u4f1a\u5b66\u8853\u5927\u4f1a\u306a\u3089\u3073\u306b\u7dcf\u4f1a\u6284\u9332\u96c6. 46(5): 172. 2004.<\/li>\n\n\n\n<li>\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u5f15\u982d\u3000\u6bc5\u3001\u85e4\u7530\u3000\u771f\u7406\u3001\u6728\u6d66\u3000\u548c\u4eba\u3001\u4e2d\u7530\u3000\u8cb4\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. Toll-like receptor 2\u306e\u30ea\u30ac\u30f3\u30c9\u8a8d\u8b58\u306b\u304a\u3051\u308b\u30ed\u30a4\u30b7\u30f3\u30ea\u30c3\u30c1\u30ea\u30d4\u30fc\u30c8\u306e\u95a2\u4e0e\u306b\u3064\u3044\u3066. \u7b2c72\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\uff08\u672d\u5e4c\uff09. \u7b2c72\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\u6284\u9332\u96c6. 2004.<\/li>\n\n\n\n<li>\u524d\u3000\u591a\u539a\u3001\u6728\u6d66\u3000\u548c\u4eba\u3001\u5b89\u7530\u3000\u5143\u662d\u3001\u85e4\u7530\u3000\u771f\u7406\u3001\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u5f15\u982d\u3000\u6bc5\u3001\u4e95\u4e0a\u3000\u8fb2\u592b\u7537\u3001\u6238\u585a\u3000\u9756\u5247\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce. \u7d30\u83cc\u8caa\u98df\u306b\u304a\u3051\u308bToll-like receptor 2\u306e\u5f79\u5272. \u7b2c72\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\uff08\u672d\u5e4c\uff09. \u7b2c72\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\u6284\u9332\u96c6. 2004.<\/li>\n\n\n\n<li>\u5f15\u982d\u3000\u6bc5\u3001\u6728\u6d66\u3000\u548c\u4eba\u3001\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u4e95\u4e0a\u3000\u8fb2\u592b\u7537\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce.\u3000Toll-like receptor 2\u4e0b\u6d41\u306b\u304a\u3051\u308bapoptosis signal-regulating kinase 1\u306e\u5f79\u5272\u306b\u3064\u3044\u3066. \u7b2c72\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\uff08\u672d\u5e4c\uff09. \u7b2c72\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u5317\u6d77\u9053\u652f\u90e8\u5b66\u8853\u7dcf\u4f1a\u6284\u9332\u96c6. 2004.<\/li>\n\n\n\n<li>\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u85e4\u7530\u3000\u771f\u7406\u3001\u4e2d\u7530\u3000\u8cb4\u3001\u6728\u6d66\u3000\u548c\u4eba\u3001\u5f15\u982d\u3000\u6bc5\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce.\u3000Toll-like receptor 2\u306e\u30ea\u30ac\u30f3\u30c9\u8a8d\u8b58\u306b\u304a\u3051\u308b\u30ed\u30a4\u30b7\u30f3\u30ea\u30c3\u30c1\u30ea\u30d4\u30fc\u30c8\u306e\u95a2\u4e0e\u306b\u3064\u3044\u3066.\u3000\u7b2c77\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u7dcf\u4f1a\uff08\u5927\u962a\uff09.\u3000\u65e5\u672c\u7d30\u83cc\u5b66\u96d1\u8a8c. 59(1):301. 2004.<\/li>\n\n\n\n<li>\u5f15\u982d\u3000\u6bc5\u3001\u6728\u6d66\u3000\u548c\u4eba\u3001\u5b89\u7530\u3000\u5143\u662d\u3001\u7247\u5ca1\u3000\u55e3\u96c4\u3001\u4e2d\u7530\u3000\u8cb4\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce.\u3000Toll\u69d8\u53d7\u5bb9\u4f53 (TLR) 2\u3068TLR6\u3092\u4ecb\u3057\u3066\u8a98\u5c0e\u3055\u308c\u308b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u89e3\u6790.\u3000\u7b2c77\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u7dcf\u4f1a\uff08\u5927\u962a\uff09.\u3000\u65e5\u672c\u7d30\u83cc\u5b66\u96d1\u8a8c. 59(1):299. 2004.<\/li>\n\n\n\n<li>\u83ca\u6c60\u3000\u88d5\u5b50\u3001\u83ca\u6c60\u3000\u4f51\u4e8c\u3001\u9ed2\u5ca9\u3000\u7406\u66a2\u3001\u67f4\u7530\u3000\u5065\u4e00\u90ce.\u3000MC-FAN\u306b\u3088\u308b\u30de\u30a4\u30b3\u30d7\u30e9\u30ba\u30de\u7531\u6765\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u6dfb\u52a0\u6642\u306e\u5168\u8840\u6d41\u52d5\u6027\u306e\u5909\u5316\u306b\u3064\u3044\u3066.\u3000\u7b2c77\u56de \u65e5\u672c\u7d30\u83cc\u5b66\u4f1a\u7dcf\u4f1a\uff08\u5927\u962a\uff09.\u3000\u65e5\u672c\u7d30\u83cc\u5b66\u96d1\u8a8c. 59(1):311. 2004<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u539f\u8457\u8ad6\u6587 \u7dcf\u8aac\u30fb\u89e3\u8aac\u30fb\u8a55\u8ad6\u7b49 \u7279\u5225\u8b1b\u6f14\u30fb\u8a18\u5ff5\u8b1b\u6f14 \u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u56fd\u969b\u5b66\u4f1a\u767a\u8868 \u56fd\u5916\u5b66\u4f1a\u767a\u8868 \u5b66\u4f1a\u767a\u8868<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"vkexunit_cta_each_option":"","footnotes":""},"class_list":["post-249","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/pages\/249","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/comments?post=249"}],"version-history":[{"count":2,"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/pages\/249\/revisions"}],"predecessor-version":[{"id":252,"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/pages\/249\/revisions\/252"}],"wp:attachment":[{"href":"https:\/\/www.den.hokudai.ac.jp\/microbiology\/wp-json\/wp\/v2\/media?parent=249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}