{"id":250,"date":"2025-04-21T22:08:52","date_gmt":"2025-04-21T13:08:52","guid":{"rendered":"https:\/\/www.den.hokudai.ac.jp\/kouge1\/wordpress\/?p=250"},"modified":"2025-04-21T22:08:53","modified_gmt":"2025-04-21T13:08:53","slug":"%e5%ad%a6%e4%bc%9a%e8%b3%9e%e3%81%aa%e3%81%a9%ef%bc%882018%e5%b9%b4%e4%bb%a5%e5%89%8d%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.den.hokudai.ac.jp\/kouge1\/research\/250","title":{"rendered":"\u5b66\u4f1a\u8cde\u306a\u3069\uff082018\u5e74\u4ee5\u524d\uff09"},"content":{"rendered":"\n<h3 class=\"wp-block-sgb-headings sgb-heading\" id=\"i-0\"><span class=\"sgb-heading__inner sgb-heading--type1 with-icon\" style=\"background-color:transparent;border-color:transparent;font-size:1.2em\"><i class=\"fa fa-check\" style=\"color:var(--wp--preset--color--sango-main)\"><\/i><span class=\"sgb-heading__text\" style=\"color:#333\">\u5b66\u4f1a\u8cde\u306a\u3069<\/span><\/span><\/h3>\n\n\n\n<p>\u7b2c53\u56de\u65e5\u672c\u53e3\u8154\u5916\u79d1\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u5927\u4f1a\u3000\u30e1\u30c0\u30eb\u30c6\u30a3\u30b9\u8cde<br>\u6d45\u9999\u5353\u54c9\uff0c\u79cb\u5c71 \u771f\u5fd7, \u5c71\u5d0e \u88d5, \u5317\u5ddd \u5584\u653f<br>\u63a5\u5408\u90e8\u578b\u5148\u5929\u6027\u8868\u76ae\u6c34\u75b1\u75c7\u306b\u304a\u3051\u308b\u30a8\u30ca\u30e1\u30eb\u8cea\u5f62\u6210\u4e0d\u5168\u306e\u767a\u75c7\u6a5f\u5e8f\u306e\u89e3\u6790<br>2008\u5e7410\u6708\uff0c\u5fb3\u5cf6<\/p>\n\n\n\n<p>\u5317\u6d77\u9053\u5927\u5b66\u6b6f\u5b66\u4f1a\u8cde<br>\u6d45\u9999\u5353\u54c9<br>\u63a5\u5408\u90e8\u578b\u5148\u5929\u6027\u8868\u76ae\u6c34\u75d8\u75c7\u306b\u304a\u3051\u308b\u30a8\u30ca\u30e1\u30eb\u8cea\u5f62\u6210\u4e0d\u5168\u306e\u767a\u75c7\u6a5f\u5e8f\u306e\u89e3\u6790<br>2010\u5e743\u6708\uff0c\u672d\u5e4c<\/p>\n\n\n\n<p>\u5317\u6d77\u9053\u5927\u5b66\u6b6f\u5b66\u4f1a\u8cde<br>\u5927\u4e45\u4fdd\u76f4\u767b<br>\u6b6f\u6839\u819c\u7531\u6765\u5e79\u7d30\u80de\u306b\u3088\u308b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u30de\u30fc\u30ab\u30fc\u967d\u6027\u8840\u7ba1\u69cb\u9020\u306e\u69cb\u7bc9<br>2011\u5e743\u6708\uff0c\u672d\u5e4c<\/p>\n\n\n\n<p>\u7b2c65\u56de\u65e5\u672c\u53e3\u8154\u79d1\u5b66\u4f1a\u5b66\u8853\u96c6\u4f1a\u3000\u5b66\u4f1a\u8cde\u512a\u79c0\u30dd\u30b9\u30bf\u30fc\u8cde<br>\u798f\u7530\u6b66\u5fd7\uff0c\u5317\u5ddd \u5584\u653f, \u8229\u6a4b \u8aa0<br>\u30e9\u30c3\u30c8\u5ef6\u9ac4\u6700\u5f8c\u91ce\u306b\u304a\u3051\u308b\u30a2\u30df\u30ea\u30f3\u306b\u3088\u308b\u30b7\u30ca\u30d7\u30b9\u4f1d\u9054\u306e\u4fee\u98fe<br>2011\u5e744\u6708\uff0c\u6771\u4eac<\/p>\n\n\n\n<p>\u5317\u6d77\u9053\u5927\u5b66\u5927\u585a\u8cde<br>\u6885\u672c\u7d18\u5b50<br>Type VII collagen deficiency causes defective tooth enamel formation due to poorly differentiated ameloblasts<br>2012\u5e743\u6708\uff0c\u672d\u5e4c<\/p>\n\n\n\n<p>\u7b2c57\u56de\u65e5\u672c\u53e3\u8154\u5916\u79d1\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u5927\u4f1a\u3000\u512a\u79c0\u30dd\u30b9\u30bf\u30fc\u8cde\uff08\u30b4\u30fc\u30eb\u30c9\u30ea\u30dc\u30f3\u8cde\uff09<br>\u4f50\u85e4\u3000\u6df3\uff0c\u963f\u90e8 \u8cb4\u6d0b, \u6d45\u9999 \u5353\u54c9, \u79e6 \u6d69\u4fe1, \u5c71\u5d0e \u88d5, \u9032\u85e4 \u6b63\u4fe1, \u5317\u5ddd \u5584\u653f<br>FMISO PET \u306f\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u60a3\u8005\u306e\u8853\u524d\u5316\u5b66\u7642\u6cd5\u306e\u52b9\u679c\u3092\u53cd\u6620\u3059\u308b<br>2012\u5e7410\u6708\uff0c\u6a2a\u6d5c<\/p>\n\n\n\n<p>\u5317\u6d77\u9053\u5927\u5b66\u6b6f\u5b66\u4f1a\u8cde<br>\u798f\u7530\u6b66\u5fd7<br>Electrophysiologically identified presynaptic mechanisms underlying amylinergic modulation of area postrema neuronal excitability in rat brain slices<br>2013\u5e743\u6708\uff0c\u672d\u5e4c<\/p>\n\n\n\n<p>AAASOM\uff08\u65e5\u672c\u5148\u7aef\u5fdc\u7528\u533b\u79d1\u5b66\u7814\u7a76\u4f1a\uff092013\u53d7\u8cde<br>\u7af9\u5185\u5eb7\u4eba\u3000\u3000<br>2013\u5e748\u6708\uff0c<\/p>\n\n\n\n<p>\u7b2c58\u56de\u65e5\u672c\u53e3\u8154\u5916\u79d1\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u5927\u4f1a\u3000\u512a\u79c0\u30dd\u30b9\u30bf\u30fc\u767a\u8868\u8cde\uff08\u30b4\u30fc\u30eb\u30c9\u30ea\u30dc\u30f3\u8cde\uff09<br>\u4f50\u85e4\u3000\u6df3\uff0c\u963f\u90e8\u8cb4\u6d0b\uff0c\u6d45\u9999\u5353\u54c9\uff0c\u79e6\u3000\u6d69\u4fe1\uff0c\u5c71\u5d0e\u3000\u88d5\uff0c\u9032\u85e4\u6b63\u4fe1\uff0c\u5317\u5ddd\u5584\u653f<br>FMISO-PET\u306f\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u306e\u4f4e\u9178\u7d20\u72b6\u614b\u306e\u307f\u306a\u3089\u305a\u7d30\u80de\u5897\u6b96\u80fd\u3092\u53cd\u6620\u3059\u308b<br>2013\u5e7410\u6708\uff0c\u798f\u5ca1<\/p>\n\n\n\n<p>\u7b2c34\u56de\u65e5\u672c\u9aa8\u5f62\u614b\u8a08\u6e2c\u5b66\u4f1a\u3000\u82e5\u624b\u7814\u7a76\u8005\u8cde<br>\u576a\u4e95\u9999\u5948\u5b50\u3001\u4f50\u3005\u6728\u5b97\u8f1d\u3001\u7e54\u7530\u516c\u5149\u3001\u5317\u5ddd\u5584\u653f\u3001\u7db2\u585a\u61b2\u751f<br>\u30d3\u30b9\u30d5\u30a9\u30b9\u30d5\u30a9\u30cd\u30fc\u30c8\u9023\u65e5\u6295\u4e0e\u306b\u3088\u308b\u9aa8\u82bd\u7d30\u80de\u30fb\u9aa8\u7d30\u80de\u3078\u306e\u5f71\u97ff\u306b\u3064\u3044\u3066\uff0e<br>2014\u5e746\u6708\uff0c\u672d\u5e4c<\/p>\n\n\n\n<p>\u7b2c59\u56de\u65e5\u672c\u53e3\u8154\u5916\u79d1\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u5927\u4f1a\u3000\u512a\u79c0\u30dd\u30b9\u30bf\u30fc\u767a\u8868\u8cde\uff08\u30b4\u30fc\u30eb\u30c9\u30ea\u30dc\u30f3\u8cde\uff09<br>\u6d45\u9999\u5353\u54c9\uff0c\u79e6\u3000\u6d69\u4fe1\uff0c\u5bae\u8170\u660c\u660e\uff0c\u4f50\u85e4\u3000\u660e\uff0c\u4f50\u85e4\u3000\u6df3\uff0c\u5317\u5ddd\u5584\u653f<br>FDG-PET\u3092\u7528\u3044\u305f\u30d3\u30b9\u30db\u30b9\u30db\u30cd\u30fc\u30c8\u95a2\u9023\u984e\u9aa8\u58ca\u6b7b\u306b\u5bfe\u3059\u308b\u9ad8\u5727\u9178\u7d20\u7642\u6cd5\u306e\u6709\u52b9\u6027\u306e\u8a55\u4fa1<br>2014\u5e7410\u6708\uff0c\u6771\u4eac<\/p>\n\n\n\n<p>\u7b2c27\u56de\u5317\u6d77\u9053\u9aa8\u7c97\u9b06\u75c7\u7814\u7a76\u4f1a\u3000\u512a\u79c0\u6f14\u984c\u8cde<br>\u576a\u4e95\u9999\u5948\u5b50\u3001\u9577\u8c37\u5ddd\u667a\u9999\u3001\u5c71\u672c\u77e5\u771f\u4e5f\u3001\u672c\u90f7\u88d5\u7f8e\u3001\u571f\u5c4b\u6075\u674e\u4f73\u3001\u539f\u53e3\u771f\u8863\u3001\u5c71\u672c\u6052\u4e4b\u3001\u5317\u5ddd\u5584\u653f\u3001\u7db2\u585a\u61b2\u751f<br>\u30a2\u30ec\u30f3\u30c9\u30ed\u30cd\u30fc\u30c8\u304c\u9aa8\u7d30\u80de\u30fb\u9aa8\u7d30\u7ba1\u7cfb\u306b\u4e0e\u3048\u308b\u753b\u50cf\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u89e3\u6790\uff0d Structured Illumination Microscopy(SIM)\u3068FIB-SEM\u306e\u5fdc\u7528\u4f8b \uff0d\uff0e<br>2015\u5e742\u6708\uff0c\u672d\u5e4c<\/p>\n\n\n\n<p>\u5317\u6d77\u9053\u5927\u5b66\u6b6f\u5b66\u4f1a\u8cde<br>\u7af9\u5185\u5eb7\u4eba<br>Detailed assessment of gene activation levels by multiple hypoxia responsive elements under various hypoxic conditions<br>2015\u5e743\u6708\uff0c\u672d\u5e4c<\/p>\n\n\n\n<p>\u65e5\u672c\u53e3\u8154\u5916\u79d1\u5b66\u4f1a\u3000\u7b2c15\u56de\u5b66\u8853\u5968\u52b1\u8cde<br>\u576a\u4e95\u9999\u5948\u5b50\uff0c\u5c71\u5d0e\u3000\u88d5\uff0c\u5c0f\u91ce\u5bfa\u9ebb\u8a18\u5b50\uff0c\u5409\u5ddd\u548c\u4eba\uff0c\u5bae\u8170\u660c\u660e\uff0c\u5927\u8cc0\u5247\u5b5d\uff0c\u79e6\u3000\u6d69\u4fe1\uff0c\u4f50\u85e4\u3000\u6df3\uff0c\u4f50\u85e4\u3000\u660e\uff0c\u5317\u5ddd\u5584\u653f<br>\u60aa\u6027\u816b\u760d\u60a3\u8005\u306b\u304a\u3051\u308b\u6ce8\u5c04\u7528BP\u95a2\u9023\u75c7\u4f8b\u306b\u5bfe\u3059\u308b\u6b6f\u79d1\u7ba1\u7406\u306e\u81e8\u5e8a\u7684\u691c\u8a0e<br>2015\u5e7410\u6708\uff0c\u540d\u53e4\u5c4b<\/p>\n\n\n\n<p>\u7b2c60\u56de\u65e5\u672c\u53e3\u8154\u5916\u79d1\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u5927\u4f1a\u3000\u512a\u79c0\u53e3\u6f14\u767a\u8868\u8cde<br>\u576a\u4e95\u9999\u5948\u5b50\uff0c\u7db2\u585a\u61b2\u751f\uff0c\u5317\u5ddd\u5584\u653f<br>\u9aa8\u82bd\u7d30\u80de\u30fb\u9aa8\u7d30\u80de\u306b\u5bfe\u3059\u308b\u30d3\u30b9\u30d5\u30a9\u30b9\u30d5\u30a9\u30cd\u30fc\u30c8\u88fd\u5264\u306e\u5f71\u97ff<br>2015\u5e7410\u6708\uff0c\u540d\u53e4\u5c4b<\/p>\n\n\n\n<p>\u7b2c 28 \u56de\u5317\u6d77\u9053\u9aa8\u7c97\u9b06\u75c7\u7814\u7a76\u4f1a\u3000\u5b66\u8853\u5968\u52b1\u8cde<br>\u571f\u5c4b\u6075\u674e\u4f73\u3001\u672c\u90f7\u88d5\u7f8e\u3001\u5c71\u672c\u77e5\u771f\u4e5f\u3001\u9577\u8c37\u5ddd\u667a\u9999\u3001\u5317\u5ddd\u5584\u653f\u3001\u7db2\u585a\u61b2\u751f<br>\u8edf\u9aa8\u5185\u9aa8\u5316\u306b\u304a\u3051\u308b\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u3068 perivascular cell (septoclast)\u306e\u7d44\u7e54\u5316\u5b66\u30fb\u5fae\u7d30\u69cb\u9020\u5b66\u7684\u691c\u7d22<br>2016\u5e742\u6708\uff0c\u672d\u5e4c<\/p>\n\n\n\n<p>\u7b2c 28 \u56de\u5317\u6d77\u9053\u9aa8\u7c97\u9b06\u75c7\u7814\u7a76\u4f1a\u3000\u512a\u79c0\u8ad6\u6587\u8cde\uff08\u57fa\u790e\u90e8\u9580\uff09<br>\u576a\u4e95\u9999\u5948\u5b50\u3001\u672c\u90f7\u88d5\u7f8e\u3001\u9577\u8c37\u5ddd\u667a\u9999\u3001\u5c71\u672c\u77e5\u771f\u4e5f\u3001\u5317\u5ddd\u5584\u653f\u3001\u7db2\u585a\u61b2\u751f<br>\u80a5\u6e802\u578b\u7cd6\u5c3f\u75c5\u30e2\u30c7\u30ebSDT fatty \u30e9\u30c3\u30c8\u306b\u304a\u3051\u308b\u9aa8\u7d44\u7e54\u306e\u7d44\u7e54\u5316\u5b66\u7684\u89e3\u6790\uff0e<br>2016\u5e742\u6708\uff0c\u672d\u5e4c<\/p>\n\n\n\n<p>\u5317\u6d77\u9053\u5927\u5b66\u6b6f\u5b66\u4f1a\u8cde<br>\u5927\u5185\u3000\u5b66<br>Age-related alteration of expression and function of TLRs and NK activity in oral candidiasis<br>2016\u5e743\u6708\u3000\u3000<\/p>\n\n\n\n<p>\u65e5\u672c\u53e3\u8154\u5916\u79d1\u5b66\u4f1a\u3000\u7b2c16\u56de\u5b66\u8853\u5968\u52b1\u8cde<br>\u5927\u8cc0\u5247\u5b5d\uff0c\u5c71\u5d0e\u3000\u88d5\uff0c\u4f50\u85e4\u3000\u6df3\uff0c\u79e6\u3000\u6d69\u4fe1\uff0c\u6751\u7530\u3000\u7ffc\uff0c\u5742\u7530\u5065\u4e00\u90ce\uff0c\u4e95\u4e0a\u3000\u6b66\uff0c\u5317\u5ddd\u5584\u653f<br>Dose escalation effectiveness and tolerability of paroxetine in patients with burning mouth syndrome and depressive conditions<br>2016\u5e7411\u6708\uff0c\u5343\u8449<\/p>\n\n\n\n<p>\u7b2c61\u56de\u65e5\u672c\u53e3\u8154\u5916\u79d1\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u5927\u4f1a\u3000\u512a\u79c0\u30dd\u30b9\u30bf\u30fc\u767a\u8868\u8cde<br>\u6d45\u9999\u5353\u54c9\uff0c\u4f50\u85e4\u3000\u6df3\uff0c\u79e6\u3000\u6d69\u4fe1\uff0c\u5bae\u8170\u660c\u660e\uff0c\u4f50\u85e4\u3000\u660e\uff0c\u5317\u5ddd\u5584\u653f<br>Metabolic activity\u3092\u7528\u3044\u305f\u984e\u9aa8\u9aa8\u9ac4\u708e\u306b\u5bfe\u3059\u308b\u65b0\u898f\u5b9a\u91cf\u7684\u8a55\u4fa1\u6cd5\u306e\u78ba\u7acb<br>2016\u5e7411\u6708\uff0c\u5343\u8449<\/p>\n\n\n\n<p>\u7b2c61\u56de\u65e5\u672c\u53e3\u8154\u5916\u79d1\u5b66\u4f1a\u7dcf\u4f1a\u30fb\u5b66\u8853\u5927\u4f1a\u3000\u512a\u79c0\u30dd\u30b9\u30bf\u30fc\u767a\u8868\u8cde<br>\u4f50\u85e4\u3000\u6df3\uff0c\u5927\u8cc0\u5247\u5b5d\uff0c\u6d45\u9999\u5353\u54c9\uff0c\u5bae\u8170\u660c\u660e\uff0c\u5409\u5ddd\u548c\u4eba\uff0c\u4f50\u85e4\u5343\u6674\uff0c\u4f50\u85e4\u3000\u660e\uff0c\u5317\u5ddd\u5584\u653f<br>\u53e3\u8154\u6241\u5e73\u4e0a\u76ae\u764c\u306b\u304a\u3051\u308b\u4f4e\u9178\u7d20\u5bb9\u7a4d\uff1ahypoxic volume\u306f\u8853\u5f8c\u306e\u4e88\u5f8c\u4e88\u6e2c\u56e0\u5b50\u306b\u306a\u308a\u3048\u308b<br>2016\u5e7411\u6708\uff0c\u5343\u8449<\/p>\n\n\n\n<p>\u5317\u6d77\u9053\u5927\u5b66\u6b6f\u5b66\u4f1a\u8cde<br>\u548c\u7530\u9ebb\u53cb\u7f8e<br>\u6c34\u75b1\u6027\u985e\u5929\u75b1\u7621\u81ea\u5df1\u6297\u4f5317\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\/BP180\u306e\u7570\u306a\u308b\u30a8\u30d4\u30c8\u30fc\u30d7\u306b\u5bfe\u3059\u308b\u6297\u4f53\u306e\u75c5\u539f\u6027\u89e3\u6790<br>2017\u5e743\u6708<\/p>\n\n\n\n<p>\u5317\u6d77\u9053\u5927\u5b66\u5927\u585a\u8cde<br>\u571f\u5c4b\u6075\u674e\u4f73<br>Histochemical assessment of the interplay between vascular endothelial cells and septoclasts during endochondral ossification in mice<br>2017\u5e743\u6708\uff0c\u672d\u5e4c<\/p>\n\n\n\n<p>\u5927\u8cc0\u5247\u5b5d\uff1a<br>\u7b2c2\u56de\u65e5\u4e2d\u984e\u9854\u9762\u5916\u79d1\u5408\u540c\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0Young Doctors Competition\u30002\u4f4d\u3000Relationship among hypoxia, 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