Features of formation of the cap enameloid in
the pharyngeal teeth of tilapia, a teleost.

Ichiro SASAGAWA


Department of Anatomy, School of Dentistry at Niigata,
The Nippon Dental University,
1-8 Hamaura-cho, Niigata 951, Japan.


Key words: Enameloid, collagen, teleost, tilapia, tooth development.


   Summary−
This study focuses on the morphological changes of the organic matrix during formation of the cap enameloid in tilapia. At the early and middle stages of enameloid matrix formation, collagen fibrils in the enameloid matrix were dispersed and about 15 nm thick. At the late stage, however, the collagen fibrils became thicker and formed interwoven thick bundles. Abundant flocculent and/or fine network-like materials, which were probably glycosaminoglycans or proteoglycans, were located between the collagen fibrils. The inner dental epithelial (IDE) cells contained large granules enclosing filamentous substances which were stained with phosphotungstic acid, suggesting that the IDE cells synthesize collagen fibrils. Morphological evidence implied that at this stage odontoblasts were also involved in the formation of enameloid matrix including collagen fibrils. Most of the organic matrix in cap enameloid was progressively removed by the epithelial cells during the stages of mineralization and maturation. The process of removal could be divided into two steps. First, the flocculent and/or fine network-like materials between the collagen fibrils disappeared, while the collagen fibrils themselves were stable and their periodic cross-banding remained visible. Second, at the stage of maturation, the collagen fibrils were completely absorbed and removed from the cap enameloid. Fine filamentous materials and tubular structures found in the cap enameloid might be remnants of the organic matrix.

   Introduction

The most interesting features during formation of the cap enameloid in teleost might be the production of the collagen fibers as an enameloid matrix and their removal from the enameloid at the late stage of formation. Large numbers of collagen fibers that form thick bundles are present in the cap enameloid matrix at the stage of formation of the enameloid matrix8 9 12 13 14 15 16 17). At the stage of mineralization of the enameloid, when the mineralization progresses from the boundary between the enameloid and the dentine to the surface of the enameloid, fine slender crystals accumulate along the collagen fibrils9 13 14 15). At the stage of maturation of the enameloid, when the degree of mineralization of the enameloid markedly increases, the collagen fibrils are completely degraded and are removed from the enameloid8 14 15 17). In spite of their removal, it seems that the orientation of the long axes of crystals in mature cap enameloid is the same as that of the collagen fibrils which have already been removed. Hence, the collagen fibers likely play an important role not only at the stage of formation of enameloid matrix but also at the stages of mineralization and maturation of enameloid in teleosts. However, details of the structure of the collagen fibrils and other visible organic matrix in cap enameloid are not well known at each stage of tooth development. The aim of this paper is to present our data regarding the fine structure of the enameloid matrix, mainly collagen fibrils, and to summarize several findings concerning the organic matrix during formation of the enameloid in tilapia.


   Materials and Methods

Three adult tilapias, Tilapia nilotica, Cichlidae, Teleostei (total length, 35-37cm), were used in this study.
After decapitation, pharyngeal tooth plates that contained tooth germs were dissected out and stored in Karnovsky fixative (cacodylate buffer, pH 7.4) overnight at room temperature. Selected specimens were then demineralized in a 2.5% solution of EDTA-2Na for about three weeks. The specimens were fixed again in a 1% solution of osmium tetroxide. After postfixation and dehydration, these specimens were embedded in Araldite-Epon resin. Semithin sections were cut with glass knives, stained with toluidine blue and then examined under a light microscope. Ultrathin sections were cut with glass or diamond knives, stained with uranyl acetate and lead citrate (U-Pb) or phosphotungstic acid (PTA), and examined under a transmission electron microscope.


   Results and Discussion

Stage of formation of the enameloid matrix

In the early and middle stages of enameloid matrix formation, a defined layer of enameloid matrix became visible between the inner dental epithelial (IDE) cells and the odontoblasts, although it was thin. Thin collagen fibrils, which ranged from 12 to 20 nm in diameter, were found in the enameloid matrix. The cross-banding pattern of the thin fibrils was often observed and showed a periodicity of about 67 nm. The spaces between the collagen fibrils were wide, so that the organic components of cap enameloid seemed to be dispersed at these stages. These collagen fibrils tended to form loose bundles and to be arranged along odontoblast processes (Fig.1).
At the late stage of enameloid matrix formation, when the production of the cap enameloid by the organic matrix was almost complete, the collagen fibrils were mainly 30-40 nm in diameter. The collagen fibrils were gathered in thick bundles that were interwoven into a pattern characteristic of cap enameloid.
It appears that the collagen fibrils in the enameloid matrix are dispersed and thin, approximately 15 nm in diameter, at the early and middle stages of enameloid matrix formation, and that the fibrils at the late stage become almost twice as thick as those at the earlier stages and form thick bundles of the type that is characteristic of teleost cap enameloid. The increase in diameter of the collagen fibrils might be due to production of the organic matrix in cap enameloid. Prostak and Skobe7) reported that the density of collagen fibrils in cap enameloid was increased in tooth buds that had nearly achieved their full thickness. It is also possible that the number of collagen fibrils increases during formation of the enameloid matrix.
Flocculent and/or fine network-like materials were visible in the spaces between the collagen fibrils at the stage of enameloid matrix formation. Periodic attachment of electron-dense materials to the cross-banding of the collagen fibrils was usually observed in the enameloid matrix (Fig.2). The presence of these fine materials that form a network-like structure and their periodic attachment to the collagen fibrils suggest that a large amount of glycosaminoglycans (GAGs) and/or proteoglycans is contained in the enameloid matrix. Kogaya4) reported that large quantities of chondroitin sulfates were detected in the developing enameloid of Polypterus, and that they were situated in close proximity to the enameloid collagen. The enameloid matrix was intensely stained by PAS-alcian blue, implying that a large quantity of tissue carbohydrates was present in the enameloid.
Many odontoblast processes were observed in the enameloid matrix from the surface to the lower region at the early and middle stages of enameloid matrix formation. Several processes were attached to the lamina densa beneath the IDE cells. At the late stage, however, the odontoblast processes were barely seen in the outer two-thirds of the enameloid matrix, while they remained present in the enameloid matrix near the odontoblasts.
At the middle stage of enameloid matrix formation, matrix vesicles 40-80 nm in diameter with a distinct unit membrane and containing few crystals were visible. At the late stage of enameloid matrix formation, the matrix vesicles contained electron-dense, crystal-like structures. Small aggregates of crystal-like structures that were associated with electron-dense fine material which was probably derived from matrix vesicles, were scattered in the apical enameloid matrix. Fine crystals are probably formed at the matrix vesicles prior to the beginning of defined mineralization along the collagen fibrils in cap enameloid.
At the late stage, the elongated odontoblasts contained abundant rER and well-developed Golgi apparatuses in the distal cytoplasm (Fig.3). Long rER enclosing fine materials were usually arranged almost parallel to the long axis of each cell. The Golgi apparatus consisted of several lamellae, many types of vesicles and vacuoles. Elongated granules with fine filamentous contents that resembled procollagen were usually found in the Golgi area. This suggests that the odontoblasts synthesize procollagen molecules. In tilapia, such morphological features of the odontoblasts imply that the odontoblasts produce considerable amounts of organic matrix including collagen as part of the enameloid matrix.
Tall columnar IDE cells contained well-developed organelles at the middle and late stages. Many extensive rER, arranged nearly parallel to the long axes of the cells, were visible in the cytoplasm. Developed Golgi apparatuses, which consisted of several lamellae, many vesicles, vacuoles and small electron-dense granules, were located around the nuclei. Elongated granules with fine filamentous contents that resembled procollagen were often found in the Golgi area. Moreover, several large granules contained fibril-like structures, about 150 nm thick with cross-banding at intervals of 32 nm, and fine electron-dense materials around the fibrils (Fig.4). In the sections stained with PTA, the contents of the large granules showed a PTA-positive fine filamentous structure (Fig.5). These two types of granules seen in the IDE cells resembled the secretory granules that were observed in the odontoblasts of mammals. This evidence suggests that the IDE cells synthesize a kind of collagen, and supports the hypothesis proposed by Prostak and his colleagues5 6 7).
It is unclear whether the bulk of collagen fibers in cap enameloid is of ectodermal origin. It is still uncertain how ectodermal procollagen molecules and/or collagen fibrils move into the enameloid matrix through the defined basal lamina beneath the IDE cells. The IDE cells in tilapia probably synthesize and secrete ectodermal collagen, but the ectodermal collagen might not be the only major component of the enameloid matrix. It is also probable that the IDE cells in teleosts secrete other proteins, such as enameline2) and proteolytic enzymes3). The proportion and distribution of the ectodermal collagen in the enameloid matrix and the role of ectodermal collagen during formation of the enameloid are subjects that must be investigated.


Stage of mineralization of the enameloid

In the stage of enameloid mineralization, marked mineralization began at the boundary between the enameloid and the dentine and advanced toward the surface side of the enameloid.
In the cap enameloid, crystal deposition that progressed along the collagen fibrils extended to the apex. An electron-dense substance covered the collagen fibrils around which fine slender crystals accumulated. In the demineralized sections, the cross-banding pattern of collagen fibrils was often visible in the region covered with the electron-dense substance. After the mineralization reached the apex of the cap enameloid, fine crystals were found at the surface region of the enameloid, bundles of collagen fibrils were loose and each collagen fibril tended to be wavy in the non-mineralized region. In this region, wide spaces were visible among the fibrils and the fine network-like materials among the collagen fibrils had disappeared. However, the thickness of collagen fibrils seemed unchanged and their cross-banding pattern remained (Fig.6). This evidence suggests that GAGs and/or proteoglycans which are situated between the collagen fibrils are mainly degraded and removed; however, the structure of collagen fibrils is maintained. The electron-dense substance begins to cover the collagen fibrils at the stage of mineralization. The electron-dense substance which was visible around the mineralized collagen might indicate the presence of non-collagenous proteins that are involved in mineralization.
In the elongated IDE cells, many long rER and mitochondria were seen in the cytoplasm. Widely distributed Golgi apparatuses were usually located at the distal side of the nuclei. Relatively many primary and secondary lysosomes were visible in the cytoplasm. The distal cell membrane was smooth and did not exhibit marked infolding. Basal lamina was still present in the non-mineralized region, but it became progressively indistinct with the progress of mineralization at the surface layer. It seems that the IDE cells at the stage of enameloid mineralization are in the transitional state between secretory cells and absorptive cells.
The outer dental epithelial (ODE) cells seemed to constitute a pseudostratified epithelial cell layer which was slightly wavy due to indentation by ingrowing capillaries. The ODE cells contained labyrinthine canalicular spaces that occupied most of the cytoplasm. A number of organelles were visible in the narrow spaces between the canaliculi. The morphological features of the ODE cells support the idea that the ODE cells might be engaged in active transport of inorganic ions1). It is likely that the ODE cells undergo a change in phenotype and become capable of active transport prior to the stage of maturation when the IDE cells have a marked ruffled border and most of the collagen fibrils disappear from the cap enameloid.


Stage of maturation of the cap enameloid

During the stage of enameloid maturation, the entire enameloid area became mineralized. The size of each crystal and the number of crystals increased in the cap enameloid, and the enameloid was packed with large crystals until the middle stage of maturation.
In demineralized sections, the majority of the organic matrix of the cap enameloid was dissolved away except for some structures. No collagen fibrils having the cross-banding pattern were found in the enameloid at this stage. In the lower region of the enameloid near the dentine, the remnants of the organic matrix consisted of microfibrils forming a network-like structure (Fig.7). At the boundary between the enameloid and the dentine, a transition between collagen fibrils showing the cross-banding pattern and scattered fine microfibrils was observed. It is certain that the collagen fibrils in cap enameloid are absorbed and transported from the enameloid at the stage of maturation8 14 15 17). In the present study, the collagen fibrils dissociated into scattered microfibrils, suggesting collagenase activity. However, there are still many uncertain points concerning the mechanism of unbinding of the collagen fibrils and their removal from the cap enameloid, as well as the presence of collagenase.
Large numbers of tubular structures, approximately 16 nm in thickness and 250 nm in observable length, were found at the outer layer of demineralized enameloid (Fig.8). It is unlikely that the tubular structures are involved in the mineralization, because their distribution is limited to the outer layer of the cervical side of enameloid, and they seem to be situated among large crystals11). It is conversely possible that the tubular structures are remnants of absorbed collagen fibrils.
Details of the structures of IDE and ODE cells at the enameloid maturation stage were already reported in the most recent issue of the Proceedings of ACBTE10). It is certain that the IDE cells having a ruffled border at their distal end and the ODE cells containing abundant canaliculi are highly involved in the absorption of organic matrix in the cap enameloid and its removal from the enameloid. Although the IDE cells having a ruffled border in teleosts might correspond to the ruffle-ended ameloblasts in mammals, a clear difference is that the IDE cells in teleosts absorb collagen fibrils. The collagen fibrils in cap enameloid are probably degraded until they exhibit no fibrous structure in the spaces in the enameloid cap, since no fibrous elements are found in the cisternae of the ruffled border of IDE cells. It is likely that the presence of epithelial cells, that is, IDE and ODE cells, is essential for the formation of hypermineralized enameloid during the mineralization and the maturation stages.

   Acknowledgement

The author is grateful to the staff at Hokuetsu Mizugiken Inc. for their kindness
in offering their facilities for the collection of specimens.


   References

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Figure legends

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Fig. 1
Thin collagen fibrils forming loose bundles in the enameloid matrix at the early and middle stages of enameloid matrix formation. Demineralized by EDTA-2Na solution, stained with uranyl acetate and lead citrate (U-Pb), bar=1μm, ×11,040.

Fig. 2
Periodic attachment of electron-dense materials to the cross-banding pattern of the collagen fibrils in the enameloid matrix. Demineralized, U-Pb, bar=200nm, ×46,000.

Fig. 3
Odontoblasts containing abundant rER, well-developed Golgi apparatuses and various types of granules at the late stage of enameloid matrix formation. Demineralized, U-Pb, bar=1μm, ×9,200.

Fig. 4
Large granules including fibril-like structures and fine electron-dense materials in the distal cytoplasm of IDE cells at the late stage of enameloid matrix formation. Demineralized, U-Pb, bar=200nm, ×64,400.

Fig. 5
Sections stained with PTA showing the large granules containing PTA-positive fine filamentous structures. Demineralized, phosphotungstic acid (PTA), bar=200nm, ×
46,000.

Fig. 6
Fine network-like materials between the collagen fibrils have disappeared during the stage of enameloid mineralization. Bundles of collagen fibrils are loose and each collagen fibril tends to be wavy in the non-mineralized enameloid matrix. Demineralized, U-Pb, bar=500nm, ×27,600.

Fig. 7
Remnants of the organic matrix consisted of microfibrils forming a network-like structure in the demineralized enameloid near the boundary between the enameloid and the dentine. Demineralized, U-Pb, bar=500nm, ×27,600.

Fig. 8
Fine tubular structures found at the outer layer of demineralized enameloid. Demineralized, U-Pb, bar=100nm, ×92,000.